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Phenotypes Associated with This Genotype
Genotype
MGI:6511096
Allelic
Composition
Agtraptm1Tamk/Agtraptm1Tamk
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtraptm1Tamk mutation (0 available); any Agtrap mutation (126 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in the epididymal fat pad in homozygous mice on a high fat diet compared to diet-match wild-type controls
• increased epididymal but not mesenteric, fat pad weight in homozygous mice on a high fat diet compared to diet-match wild-type controls
• on a normal chow diet ft pad weight is similar to wild-type controls
• increased accumulation of infiltrating macrophages in white adipose tissue

cardiovascular system
N
• blood pressure and heart rate are not significantly different from diet matched controls

hematopoietic system
• increased accumulation of infiltrating macrophages in white adipose tissue

homeostasis/metabolism
N
• total cholesterol levels are similar to controls
• increase in nonfasting plasma insulin concentrations in homozygous mice on a high fat diet compared to diet-match wild-type controls
• increase in plasma free fatty acids on either a normal chow or high fat diet
• elevated fasting triglyceride levels
• increase in plasma glycated albumin in homozygous mice on a high fat diet compared to diet-match wild-type controls
• glucose lowering effect of insulin is impaired in homozygous mice on a high fat diet compared to diet-match wild-type controls

immune system
• increased accumulation of infiltrating macrophages in white adipose tissue

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acquired metabolic disease DOID:0060158 J:263253


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory