Phenotypes Associated with This Genotype

Genotype
MGI:6511096

• Allelic Composition: Agtrap^tm1Tamk/Agtrap^tm1Tamk
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased fat cell size ( J:263253 )

• in the epididymal fat pad in homozygous mice on a high fat diet compared to diet-match wild-type controls

increased epididymal fat pad weight ( J:263253 )

• increased epididymal but not mesenteric, fat pad weight in homozygous mice on a high fat diet compared to diet-match wild-type controls

• on a normal chow diet ft pad weight is similar to wild-type controls

abnormal white adipose tissue morphology ( J:263253 )

• increased accumulation of infiltrating macrophages in white adipose tissue

cardiovascular system

cardiovascular system phenotype ( J:263253 )

N • blood pressure and heart rate are not significantly different from diet matched controls

hematopoietic system

abnormal macrophage morphology ( J:263253 )

• increased accumulation of infiltrating macrophages in white adipose tissue

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:263253 )

N • total cholesterol levels are similar to controls

increased circulating insulin level ( J:263253 )

• increase in nonfasting plasma insulin concentrations in homozygous mice on a high fat diet compared to diet-match wild-type controls

increased circulating free fatty acids level ( J:263253 )

• increase in plasma free fatty acids on either a normal chow or high fat diet

increased circulating triglyceride level ( J:263253 )

• elevated fasting triglyceride levels

increased circulating serum albumin level ( J:263253 )

• increase in plasma glycated albumin in homozygous mice on a high fat diet compared to diet-match wild-type controls

insulin resistance ( J:263253 )

• glucose lowering effect of insulin is impaired in homozygous mice on a high fat diet compared to diet-match wild-type controls

immune system

abnormal macrophage morphology ( J:263253 )

• increased accumulation of infiltrating macrophages in white adipose tissue

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acquired metabolic disease		DOID:0060158		J:263253