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Bhmt
Gene Detail
 Symbol
Name
ID
Bhmt
betaine-homocysteine methyltransferase
MGI:1339972
Feature Type protein coding gene
Genetic Map
Chromosome 13
47.87 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:93616891-93637961 bp, - strand
From VEGA annotation of GRCm38

  21071 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1295  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: betaine--homocysteine S-methyltransferase, BHMT type
Gene Tree: Bhmt

Human
homologs
Human Homolog BHMT, betaine--homocysteine S-methyltransferase
NCBI Gene ID 635
neXtProt AC  NX_Q93088
Human Synonyms  BHMT1, HEL-S-61p
Human Chr (Location)  5q14.1; chr5:79111781-79132290 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit slow postnatal weight gain, altered homocysteine, choline, and one-carbon homeostasis, fatty liver, and hepatocellular carcinomas.
 
Interactions
Bhmt interacts with 99 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process amino-acid betaine metabolic process, L-methionine salvage, ...
Component cytoplasm, cytosol, ...
Function betaine-homocysteine S-methyltransferase activity, methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (167)    Tissues (98)    Images (49)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 151
Northern blot 16
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000024452 (Evidence)
Ensembl Gene ModelENSMUSG00000074768 (Evidence)
Entrez Gene12116 (Evidence)
DFCITC1573529, TC1604064
NIA Mouse Gene IndexU018980, U024901, U035037
Consensus CDS ProjectCCDS36748.1
International Mouse Knockout Project StatusBhmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024452 VEGA Gene Model | MGI Sequence Detail 21071 C57BL/6J ±  kb
transcript OTTMUST00000059960 VEGA | MGI Sequence Detail 2274 Not Applicable 
polypeptide OTTMUSP00000029215 VEGA | MGI Sequence Detail 407 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2)
Polymorphisms SNPs within 2kb(153 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000004742 betaine--homocysteine S-methyltransferase 1
References (Earliest) J:62863 Neece DJ, et al., Isolation and characterization of a mouse betaine-homocysteine S-methyltransferase gene and pseudogene. Gene. 2000 May 30;250(1-2):31-40
(Latest) J:192970 Lee MB, et al., Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development. J Biol Chem. 2012 Sep 21;287(39):33094-103
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory