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Csf1r Gene Detail
Summary
  • Symbol
    Csf1r
  • Name
    colony stimulating factor 1 receptor
  • Synonyms
    CD115, CSF-1R, Csfmr, Fim2, Fim-2, Fms, M-CSFR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339758
    NCBI Gene: 12978
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:61105572-61131134 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25563 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.41 cM, cytoband D
  • Mapping Data
    25 experiments
Homology
more
  • Human Ortholog
    CSF1R, colony stimulating factor 1 receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSF1R, colony stimulating factor 1 receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD115, C-FMS, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
  • Links
    NCBI Gene ID: 1436
    neXtProt AC: NX_P07333
    UniProt: P07333

  • Chr Location
    5q32; chr5:150053291-150113372 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit skeletal, sensory, and reproductive abnormalities associated with severe deficiencies in osteoclasts, macrophages, and brain microglia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014918 VEGA Gene Model | MGI Sequence Detail 25563 C57BL/6J ±  kb
    transcript OTTMUST00000035435 VEGA | MGI Sequence Detail 3870 Not Applicable  
    polypeptide OTTMUSP00000015851 VEGA | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      154 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 8
      cDNA 41
      Primer pair 7
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2192, MGD-MRK-9798, MGD-MRK-9845, MGI:2147208, MGI:88535
    References
    more
    • Summaries
      All 207
      Developmental Gene Expression 42
      Gene Ontology 22
      Phenotypes 30
    • Earliest
      J:6867 Muller R, et al., Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature. 1982 Oct 14;299(5884):640-4
    • Latest
      J:263738 Nakayama H, et al., Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum. Nat Commun. 2018 Jul 19;9(1):2830

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory