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Csf1r
Gene Detail
 Symbol
Name
ID
Csf1r
colony stimulating factor 1 receptor
MGI:1339758
Synonyms CD115, CSF-1R, Csfmr, Fim-2, Fms, M-CSFR
Feature Type protein coding gene
Genetic Map
Chromosome 18
34.41 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr18:61105572-61131134 bp, + strand
From VEGA annotation of GRCm38

  25563 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 2 zebrafish

Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Csf1r

Human
homologs
Human Homolog CSF1R, colony stimulating factor 1 receptor
NCBI Gene ID 1436
neXtProt AC  NX_P07333
Human Synonyms  CD115, C-FMS, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
Human Chr (Location)  5q32; chr5:150053291-150113372 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CSF1R
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit skeletal, sensory, and reproductive abnormalities associated with severe deficiencies in osteoclasts, macrophages, and brain microglia.
 
Interactions
Csf1r interacts with 228 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process cell-cell junction maintenance, cell proliferation, ...
Component cell surface, integral component of membrane, ...
Function ATP binding, cytokine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (218)    Tissues (140)    Images (20)
Theiler Stages: 4, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 74
Northern blot 9
RT-PCR 122
Nuclease S1 5
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) Genomic(8) cDNA(40) Primer pair(7) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000014918 (Evidence)
Ensembl Gene ModelENSMUSG00000024621 (Evidence)
Entrez Gene12978 (Evidence)
DFCITC1573741, TC1607361, TC1637006, TC1687081, TC1695820
DoTSDT.101139906, DT.101163850, DT.101406752, DT.101406754, DT.110764711, DT.491839, DT.55147791, DT.97364722, DT.97364723
EC2.7.10.1
PDB3EJJ, 4EXP
Consensus CDS ProjectCCDS29280.1
International Mouse Knockout Project StatusCsf1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014918 VEGA Gene Model | MGI Sequence Detail 25563 C57BL/6J ±  kb
transcript OTTMUST00000035435 VEGA | MGI Sequence Detail 3870 Not Applicable 
polypeptide OTTMUSP00000015851 VEGA | MGI Sequence Detail 977 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(13) UniProt(11)
Polymorphisms RFLP(10) : SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR022409 PKD/Chitinase domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Protein Ontology PR:000002062 macrophage colony-stimulating factor 1 receptor
References (Earliest) J:6867 Muller R, et al., Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature. 1982 Oct 14;299(5884):640-4
(Latest) J:206879 Huang T, et al., BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014 Feb 15;386(2):308-20
All references(159)
Other
accession IDs
MGD-MRK-2192, MGD-MRK-9798, MGD-MRK-9845, MGI:2147208, MGI:88535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory