Csf1r
Gene Detail

Symbol Name ID

Csf1r colony stimulating factor 1 receptor MGI:1339758

Synonyms

CD115, CSF-1R, Csfmr, Fim-2, Fms, M-CSFR

Feature Type

protein coding gene

Genetic Map

Chromosome 18

34.41 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr18:61105572-61131134 bp, + strand From VEGA annotation of GRCm38   25563 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type
Gene Tree: Csf1r

Human homologs

Human Homolog		CSF1R, colony stimulating factor 1 receptor
NCBI Gene ID		1436
neXtProt AC		NX_P07333
Human Synonyms		CD115, C-FMS, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
Human Chr (Location)		5q32; chr5:149432854-149492935 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CSF1R

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for a targeted null mutation exhibit skeletal, sensory, and reproductive abnormalities associated with severe deficiencies in osteoclasts, macrophages, and brain microglia.

 

Gene Ontology (GO) classifications

All GO classifications: (62 annotations)

Process	cell-cell junction maintenance, cell proliferation, ...
Component	cell surface, integral to membrane, ...
Function	ATP binding, cytokine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (39 records)
Data Summary: Results (183)    Tissues (116)    Images (20)
Theiler Stages: 4, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	73
Northern blot	9
RT-PCR	88
Nuclease S1	5

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(57) Genomic(8) cDNA(40) Primer pair(6) Other(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000014918 (Evidence)
Ensembl Gene Model	ENSMUSG00000024621 (Evidence)
Entrez Gene	12978 (Evidence)
DFCI	TC1573741, TC1607361, TC1637006, TC1687081, TC1695820
DoTS	DT.101139906, DT.101163850, DT.101406752, DT.101406754, DT.110764711, DT.491839, DT.55147791, DT.97364722, DT.97364723
EC	2.7.10.1
PDB	3EJJ, 4EXP
Consensus CDS Project	CCDS29280.1
International Mouse Knockout Project Status	Csf1r

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014918	VEGA Gene Model | MGI Sequence Detail	25563	C57BL/6J
transcript	OTTMUST00000035435	VEGA | MGI Sequence Detail	3870	Not Applicable
polypeptide	OTTMUSP00000015851	VEGA | MGI Sequence Detail	977	Not Applicable

All sequences(70) RefSeq(3) UniProt(11)

Polymorphisms

RFLP(10) : SNPs(119 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR022409	PKD/Chitinase domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016243	Tyrosine-protein kinase, CSF-1/PDGF receptor
InterPro	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
Protein Ontology	PR:000002062	macrophage colony-stimulating factor 1 receptor

References

(Earliest) J:6867 Muller R, et al., Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature. 1982 Oct 14;299(5884):640-4
(Latest) J:194761 Luo J, et al., Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med. 2013 Jan 14;210(1):157-72
All references(152)

Other accession IDs

MGD-MRK-2192, MGD-MRK-9798, MGD-MRK-9845, MGI:2147208, MGI:88535