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Csf1r Gene Detail
Summary
  • Symbol
    Csf1r
  • Name
    colony stimulating factor 1 receptor
  • Synonyms
    CD115, CSF-1R, Csfmr, Fim2, Fim-2, Fms, M-CSFR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339758
    NCBI Gene: 12978
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61105572-61132149 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.41 cM, cytoband D
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339758
protein coding gene Chr18:61096809-61132149 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024475
protein coding gene Chr18:60962759-60991027 (+)
A/J MGP_AJ_G0024442
protein coding gene Chr18:58353045-58379634 (+)
AKR/J MGP_AKRJ_G0024412
protein coding gene Chr18:59961835-59988309 (+)
BALB/cJ MGP_BALBcJ_G0024441
protein coding gene Chr18:58483997-58510446 (+)
C3H/HeJ MGP_C3HHeJ_G0024209
protein coding gene Chr18:60187184-60214420 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024888
protein coding gene Chr18:62617314-62645157 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022319
protein coding gene Chr18:57899945-57926483 (+)
CAST/EiJ MGP_CASTEiJ_G0023682
protein coding gene Chr18:60057618-60085719 (+)
CBA/J MGP_CBAJ_G0024179
protein coding gene Chr18:64623301-64649696 (+)
DBA/2J MGP_DBA2J_G0024309
protein coding gene Chr18:58022028-58048548 (+)
FVB/NJ MGP_FVBNJ_G0024275
protein coding gene Chr18:57430735-57457593 (+)
LP/J MGP_LPJ_G0024392
protein coding gene Chr18:60814081-60841652 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024304
protein coding gene Chr18:66255491-66283316 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024935
protein coding gene Chr18:60152452-60179684 (+)
PWK/PhJ MGP_PWKPhJ_G0023425
protein coding gene Chr18:58250419-58278110 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023231
protein coding gene Chr18:60381955-60408737 (+)
WSB/EiJ MGP_WSBEiJ_G0023746
protein coding gene Chr18:60008029-60035628 (+)



Homology
more
  • Human Ortholog
    CSF1R, colony stimulating factor 1 receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSF1R, colony stimulating factor 1 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD115, C-FMS, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
  • Links
    NCBI Gene ID: 1436
    neXtProt AC: NX_P07333
    UniProt: P07333

  • Chr Location
    5q32; chr5:150053291-150113372 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit skeletal, sensory, and reproductive abnormalities associated with severe deficiencies in osteoclasts, macrophages, and brain microglia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024621 Ensembl Gene Model | MGI Sequence Detail 26578 C57BL/6J ±  kb
    transcript ENSMUST00000025523 Ensembl | MGI Sequence Detail 3870 Not Applicable  
    polypeptide ENSMUSP00000025523 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 8
      cDNA 41
      Primer pair 7
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2192, MGD-MRK-9798, MGD-MRK-9845, MGI:2147208, MGI:88535
    References
    more
    • Summaries
      All 210
      Developmental Gene Expression 43
      Gene Ontology 23
      Phenotypes 33
    • Earliest
      J:6867 Muller R, et al., Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature. 1982 Oct 14;299(5884):640-4
    • Latest
      J:264675 Fransen MF, et al., A Restricted Role for FcgammaR in the Regulation of Adaptive Immunity. J Immunol. 2018 Apr 15;200(8):2615-2626

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory