Csf1
Gene Detail

Symbol Name ID

Csf1 colony stimulating factor 1 (macrophage) MGI:1339753

Synonyms

colony-stimulating factor-1, CSF-1, Csfm, M-CSF

Feature Type

protein coding gene

Genetic Map

Chromosome 3

46.83 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr3:107741048-107760469 bp, - strand From VEGA annotation of GRCm38   19422 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: macrophage colony-stimulating factor 1
Gene Tree: Csf1

Human homologs

Human Homolog		CSF1, colony stimulating factor 1 (macrophage)
NCBI Gene ID		1435
neXtProt AC		NX_P09603
Human Synonyms		CSF-1, MCSF
Human Chr (Location)		1p13.3; chr1:110453233-110473616 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Spontaneous(1)
 

Homozygotes for a spontaneous mutation exhibit lack of incisors, a broad domed skull, short thick limb bones with reduced marrow cavities, impaired hearing and vision, and reduced fertility in females.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	branching involved in mammary gland duct morphogenesis, cell proliferation, ...
Component	extracellular region, extracellular space, ...
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (65)    Tissues (33)    Images (1)
Theiler Stages: 13, 14, 15, 19, 21, 23, 24, 25, 26, 28

Assay Type	Results
Northern blot	30
RT-PCR	29
Nuclease S1	6

cDNA source data(98)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(107) Genomic(4) cDNA(99) Primer pair(2) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026573 (Evidence)
Ensembl Gene Model	ENSMUSG00000014599 (Evidence)
Entrez Gene	12977 (Evidence)
UniGene	795
DFCI	TC1576651, TC1593319, TC1596023
DoTS	DT.101312104, DT.111042454, DT.94133549, DT.94150590
NIA Mouse Gene Index	U024503
PDB	3EJJ, 4ADQ, 3UF5
Consensus CDS Project	CCDS17740.1, CCDS51044.1
International Mouse Knockout Project Status	Csf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026573	VEGA Gene Model | MGI Sequence Detail	19422	C57BL/6J
transcript	OTTMUST00000065739	VEGA | MGI Sequence Detail	4176	Not Applicable
polypeptide	OTTMUSP00000032802	VEGA | MGI Sequence Detail	552	Not Applicable

All sequences(72) RefSeq(6) UniProt(7)

Polymorphisms

RFLP(3) : SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR008001	Macrophage colony stimulating factor-1
Protein Ontology	PR:000005930	macrophage colony-stimulating factor 1

References

(Earliest) J:5149 Ruddle FH, et al., Esterase genetics in Mus musculus: expression, linkage, and polymorphism of locus Es-2. Genetics. 1969 Jun;62(2):393-9
(Latest) J:194761 Luo J, et al., Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med. 2013 Jan 14;210(1):157-72
All references(337)

Other accession IDs

MGD-MRK-13034, MGD-MRK-2191, MGI:2140102, MGI:88534