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Csf1
Gene Detail
 Symbol
Name
ID
Csf1
colony stimulating factor 1 (macrophage)
MGI:1339753
Synonyms colony-stimulating factor-1, CSF-1, Csfm, M-CSF
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.83 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr3:107741048-107760469 bp, - strand
From VEGA annotation of GRCm38

  19422 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: macrophage colony-stimulating factor 1
Gene Tree: Csf1

Human
homologs
Human Homolog CSF1, colony stimulating factor 1 (macrophage)
NCBI Gene ID 1435
neXtProt AC  NX_P09603
Human Synonyms  CSF-1, MCSF
Human Chr (Location)  1p13.3; chr1:109910611-109930994 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Spontaneous(1)
 
Homozygotes for a spontaneous mutation exhibit lack of incisors, a broad domed skull, short thick limb bones with reduced marrow cavities, impaired hearing and vision, and reduced fertility in females.
 
Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process branching involved in mammary gland duct morphogenesis, cell proliferation, ...
Component extracellular region, extracellular space, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (110)    Tissues (60)    Images (1)
Theiler Stages: 13, 14, 15, 19, 21, 23, 24, 25, 26, 28
Assay TypeResults
Northern blot 30
RT-PCR 74
Nuclease S1 6
cDNA source data(101)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(111) Genomic(4) cDNA(102) Primer pair(3) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026573 (Evidence)
Ensembl Gene ModelENSMUSG00000014599 (Evidence)
Entrez Gene12977 (Evidence)
UniGene795
DFCITC1576651, TC1593319, TC1596023
DoTSDT.101312104, DT.111042454, DT.94133549, DT.94150590
NIA Mouse Gene IndexU024503
PDB3EJJ, 4ADQ, 3UF5
Consensus CDS ProjectCCDS17740.1, CCDS51044.1
International Mouse Knockout Project StatusCsf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026573 VEGA Gene Model | MGI Sequence Detail 19422 C57BL/6J ±  kb
transcript OTTMUST00000065739 VEGA | MGI Sequence Detail 4176 Not Applicable 
polypeptide OTTMUSP00000032802 VEGA | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(6) UniProt(7)
Polymorphisms RFLP(3) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR008001 Macrophage colony stimulating factor-1
Protein Ontology PR:000005930 macrophage colony-stimulating factor 1
References (Earliest) J:5149 Ruddle FH, et al., Esterase genetics in Mus musculus: expression, linkage, and polymorphism of locus Es-2. Genetics. 1969 Jun;62(2):393-9
(Latest) J:198377 Sielska M, et al., Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response. J Pathol. 2013 Jul;230(3):310-21
All references(342)
Other
accession IDs
MGD-MRK-13034, MGD-MRK-2191, MGI:2140102, MGI:88534

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory