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Csf1 Gene Detail
Summary
  • Symbol
    Csf1
  • Name
    colony stimulating factor 1 (macrophage)
  • Synonyms
    colony-stimulating factor-1, CSF-1, Csfm, M-CSF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339753
    NCBI Gene: 12977
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:107741048-107760469 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19422 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.83 cM, cytoband F3
  • Mapping Data
    24 experiments
Homology
more
  • Human Ortholog
    CSF1, colony stimulating factor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CSF1, colony stimulating factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSF-1, MCSF
  • Links
    NCBI Gene ID: 1435
    neXtProt AC: NX_P09603
    UniProt: P09603

  • Chr Location
    1p13.3; chr1:109910506-109930994 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Csf1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    131 phenotypes from 2 alleles in 5 genetic backgrounds
    38 phenotypes from multigenic genotypes
    3 images
    221 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit lack of incisors, a broad domed skull, short thick limb bones with reduced marrow cavities, impaired hearing and vision, and reduced fertility in females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026573 VEGA Gene Model | MGI Sequence Detail 19422 C57BL/6J ±  kb
    transcript OTTMUST00000065739 VEGA | MGI Sequence Detail 4176 Not Applicable  
    polypeptide OTTMUSP00000032802 VEGA | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      60 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 4
      cDNA 103
      Primer pair 3
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13034, MGD-MRK-2191, MGI:2140102, MGI:88534
    References
    more
    • Summaries
      All 402
      Developmental Gene Expression 25
      Diseases 2
      Gene Ontology 22
      Phenotypes 221
    • Earliest
      J:5149 Ruddle FH, et al., Esterase genetics in Mus musculus: expression, linkage, and polymorphism of locus Es-2. Genetics. 1969 Jun;62(2):393-9
    • Latest
      J:261653 Avetisyan M, et al., Muscularis macrophage development in the absence of an enteric nervous system. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4696-4701

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory