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Acvr1b
Gene Detail
 Symbol
Name
ID
Acvr1b
activin A receptor, type 1B
MGI:1338944
Synonyms ActRIB, ActR-IB, Acvrlk4, Alk4, SKR2
Feature Type protein coding gene
Genetic Map
Chromosome 15
56.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:101174125-101212601 bp, + strand
From NCBI annotation of GRCm38

  38477 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: type I serine/threonine-protein kinase receptor, Activin/BMP/TGF-beta types
Gene Tree: Acvr1b

Human
homologs
Human Homolog ACVR1B, activin A receptor, type IB
NCBI Gene ID 91
neXtProt AC  NX_P36896
Human Synonyms  ACTRIB, ACVRLK4, ALK4, SKR2
Human Chr (Location)  12q13; chr12:51951667-51997079 (+)  GRCh38
Alleles
and
phenotypes
All alleles(19) : Targeted(8) Gene trapped(11)
 
Embryos homozygous for targeted mutations that inactivate the gene arrest at the egg cylinder stage, prior to gastrulation, showing epiblast and extraembryonic ectoderm disorganization.
 
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process activin receptor signaling pathway, cell surface receptor signaling pathway, ...
Component cell surface, integral component of membrane, ...
Function activin-activated receptor activity, activin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (378)    Tissues (145)    Images (55)
Theiler Stages: 2, 3, 7, 8, 9, 11, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 325
Northern blot 8
RT-PCR 45
cDNA source data(76)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(83) Genomic(1) cDNA(76) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000000532 (Evidence)
Entrez Gene11479 (Evidence)
UniGene308467
DFCITC1580398, TC1601845, TC1602576
DoTSDT.531744, DT.97368392
NIA Mouse Gene IndexU016682
EC2.7.11.30
Consensus CDS ProjectCCDS27846.1
International Mouse Knockout Project StatusAcvr1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11479 NCBI Gene Model | MGI Sequence Detail 38477 C57BL/6J ±  kb
transcript NM_007395 RefSeq | MGI Sequence Detail 3277 C57BL/6 
polypeptide Q61271 UniProt | EBI | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
InterPro IPR003605 TGF beta receptor, GS motif
Protein Ontology PR:000000068 activin receptor type-1B
Graphical View of Protein Domain Structure
References (Earliest) J:27756 Verschueren K, et al., Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech Dev. 1995 Jul;52(1):109-23
(Latest) J:200671 Economides AN, et al., Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88
All references(68)
Other
accession IDs
MGD-MRK-25637, MGI:104309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory