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Acvr1b
Gene Detail
Symbol

Name
ID
Acvr1b
activin A receptor, type 1B
MGI:1338944
Synonyms
ActRIB, ActR-IB, Acvrlk4, Alk4, SKR2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:101174067-101213679 bp, + strand
From VEGA annotation of GRCm38

  39613 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: type I serine/threonine-protein kinase receptor, Activin/BMP/TGF-beta types
Gene Tree: Acvr1b

Human
homologs
Human Homolog ACVR1B, activin A receptor, type IB
NCBI Gene ID 91
neXtProt AC  NX_P36896
Human Synonyms  ACTRIB, ACVRLK4, ALK4, SKR2
Human Chr (Location)  12q13; chr12:51951667-51997079 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(11) Radiation induced(1) Targeted(8)
Genomic Mutations involving Acvr1b (1)
 
Embryos homozygous for targeted mutations that inactivate the gene arrest at the egg cylinder stage, prior to gastrulation, showing epiblast and extraembryonic ectoderm disorganization.
 
Interactions
Acvr1b interacts with 358 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (378)    Tissues (145)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 325
Northern blot 8
RT-PCR 45
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) Genomic(1) cDNA(76) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000048171 (Evidence)
Ensembl Gene ModelENSMUSG00000000532 (Evidence)
Entrez Gene11479 (Evidence)
UniGene308467
DFCITC1602576, TC1580398, TC1601845
DoTSDT.531744, DT.97368392
NIA Mouse Gene IndexU016682
EC2.7.11.30
Consensus CDS ProjectCCDS27846.1
International Mouse Knockout Project StatusAcvr1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048171 VEGA Gene Model | MGI Sequence Detail 39613 C57BL/6J ±  kb
transcript OTTMUST00000123695 VEGA | MGI Sequence Detail 4413 Not Applicable 
polypeptide OTTMUSP00000067473 VEGA | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000333 Activin type II/Transforming growth factor-beta II receptor
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
InterPro IPR003605 TGF beta receptor, GS motif
Protein Ontology PR:000000068 activin receptor type-1B
References
(Earliest) J:27756 Verschueren K, et al., Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech Dev. 1995 Jul;52(1):109-23
(Latest) J:200671 Economides AN, et al., Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88
All references(71)
Other
accession IDs
MGD-MRK-25637, MGI:104309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory