Acvr1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Acvr1b
activin A receptor, type 1B
MGI:1338944

40 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Acvr1b^{tm1.1(KOMP)Vlcg}/Acvr1b⁺ C57BL/6N-Acvr1b^{tm1.1(KOMP)Vlcg}/Ucd	abnormal coat/ hair morphology	J:211773
	abnormal uterus morphology	J:211773
	enlarged lymph nodes	J:211773
	small adrenal glands	J:211773
	small testis	J:211773
Acvr1b^{tm1.1(KOMP)Vlcg}/Acvr1b^{tm1.1(KOMP)Vlcg} C57BL/6N-Acvr1b^{tm1.1(KOMP)Vlcg}/Ucd	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Acvr1b^tm1.1Gsu/Acvr1b^tm1.1Gsu Tg(KRT14-cre)8Brn/0 involves: 129 * C57BL/6J * FVB	abnormal epidermal layer morphology	J:171766
	abnormal hair cycle	J:171766
	abnormal hair follicle morphology	J:171766
	abnormal hair follicle regression	J:171766
	abnormal hair growth	J:171766
	abnormal incisor color	J:171766
	abnormal lower incisor morphology	J:171766
	abnormal skin adnexa physiology	J:171766
	abnormal skin physiology	J:171766
	abnormal skin sebaceous gland morphology	J:171766
	alopecia	J:171766
	normal digestive/alimentary phenotype	J:171766
	dilated hair follicle	J:171766
	enlarged sebaceous gland	J:171766
	epidermal cyst	J:171766
	hairless	J:171766
	postnatal growth retardation	J:171766
	normal reproductive system phenotype	J:171766
	thick epidermis	J:171766
	thick epidermis stratum basale	J:171766
Acvr1b^tm1.1Gsu/Acvr1b^tm1.1Gsu Tg(KRT14-cre)8Brn/Tg(KRT14-cre)8Brn involves: 129 * C57BL/6J * FVB	alopecia	J:171766
	postnatal growth retardation	J:171766
Acvr1b^tm1.1Pbe/Acvr1b^tm1.1Pbe involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL	embryonic lethality, complete penetrance	J:188629
Acvr1b^tm1Enl/Acvr1b^tm1Enl either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)	abnormal cell differentiation	J:46637
	abnormal distal visceral endoderm morphology	J:46637
	abnormal embryonic epiblast morphology	J:46637
	abnormal extraembryonic ectoderm morphology	J:46637
	abnormal visceral endoderm morphology	J:46637
	absent egg cylinders	J:46637
	absent mesoderm	J:46637
	disorganized extraembryonic tissue	J:46637
	embryonic growth arrest	J:46637
	embryonic lethality during organogenesis, complete penetrance	J:46637
	failure of primitive streak formation	J:46637
Acvr1b^tm2.1Vlcg/Acvr1b^tm2.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac	no abnormal phenotype detected	J:200671

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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