Acvr1b^tm1.1Gsu
Targeted Allele Detail

Summary

• Symbol: Acvr1b^tm1.1Gsu
• Name: activin A receptor, type 1B; targeted mutation 1.1, Gloria H Su
• MGI ID: MGI:5000108
• Synonyms: Acvr1b^flox
• Gene: Acvr1b Location: Chr15:101071953-101111565 bp, + strand Genetic Position: Chr15, 56.48 cM
• Alliance: Acvr1b^tm1.1Gsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171766
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 1 and an FRT flanked neo cassette and loxP site were inserted in intron 3 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 2 and 3 floxed. (J:171766)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acvr1b Mutation: 36 strains or lines available

References

• Original: J:171766 Qiu W, et al., Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality. J Invest Dermatol. 2011 May;131(5):1067-76
• All: 4 reference(s)