Acvr1b^tm1.1Pbe
Targeted Allele Detail

Summary

• Symbol: Acvr1b^tm1.1Pbe
• Name: activin A receptor, type 1B; targeted mutation 1.1, Philippe Bertolino
• MGI ID: MGI:5441233
• Synonyms: Acvr1bDel5-6, Acvr1bf^delta
• Gene: Acvr1b Location: Chr15:101071953-101111565 bp, + strand Genetic Position: Chr15, 56.48 cM
• Alliance: Acvr1b^tm1.1Pbe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188629
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neo casette and loxP site were inserted in intron 4. An additional loxP was inserted into intron 6. Cre-mediated recombination removed the FRT-flanked neo casette, exon 5 and exon 6. (J:188629)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr1b Mutation: 36 strains or lines available

References

• Original: J:188629 Ripoche D, et al., Generation of a conditional mouse model to target Acvr1b disruption in adult tissues. Genesis. 2013 Feb;51(2):120-7
• All: 1 reference(s)