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Nr1i2
Gene Detail
Symbol

Name
ID
Nr1i2
nuclear receptor subfamily 1, group I, member 2
MGI:1337040
Synonyms
mPXR, Pregnane X receptor, PXR, PXR.1, PXR.2, SXR
Feature Type
protein coding gene
Genetic Map
Chromosome 16
26.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:38248323-38294824 bp, - strand
From VEGA annotation of GRCm38

  46502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40757  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: vitamin D3 receptor-like nuclear receptor
Gene Tree: Nr1i2

Human
homologs
Human Homolog NR1I2, nuclear receptor subfamily 1, group I, member 2
NCBI Gene ID 8856
neXtProt AC  NX_O75469
Human Synonyms  BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Human Chr (Location)  3q12-q13.3; chr3:119780484-119818485 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable and fertile but exhibit specific loss of xenoregulation of CYP3A11.
 
Interactions
Nr1i2 interacts with 133 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process drug export, exogenous drug catabolic process, ...
Component nucleus
Function DNA binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (60)    Tissues (39)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(15)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023687 (Evidence)
Ensembl Gene ModelENSMUSG00000022809 (Evidence)
Entrez Gene18171 (Evidence)
UniGene8509
DFCITC1585950
DoTSDT.60101067, DT.91338829
NIA Mouse Gene IndexU037034
Consensus CDS ProjectCCDS28164.1
International Mouse Knockout Project StatusNr1i2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023687 VEGA Gene Model | MGI Sequence Detail 46502 C57BL/6J ±  kb
transcript OTTMUST00000057839 VEGA | MGI Sequence Detail 2553 Not Applicable 
polypeptide OTTMUSP00000027962 VEGA | MGI Sequence Detail 431 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011397 nuclear receptor subfamily 1 group I member 2
References
(Earliest) J:50706 Bertilsson G, et al., Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12208-13
(Latest) J:209513 Spruiell K, et al., Role of pregnane X receptor in obesity and glucose homeostasis in male mice. J Biol Chem. 2014 Feb 7;289(6):3244-61
All references(109)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory