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Nr1i2
Gene Detail
Symbol

Name
ID
Nr1i2
nuclear receptor subfamily 1, group I, member 2
MGI:1337040
Synonyms
mPXR, Pregnane X receptor, PXR, PXR.1, PXR.2, SXR
Feature Type
protein coding gene
Genetic Map
Chromosome 16
26.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:38248323-38294824 bp, - strand
From VEGA annotation of GRCm38

  46502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40757  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NR1I2
Protein SuperFamily: vitamin D3 receptor-like nuclear receptor
Gene Tree: Nr1i2

Human
homologs
NR1I2, nuclear receptor subfamily 1, group I, member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8856
neXtProt AC: NX_O75469

Human Synonyms: BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR

Human Chr (Location): 3q12-q13.3; chr3:119780484-119818485 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable and fertile but exhibit specific loss of xenoregulation of CYP3A11.
 
Interactions
Nr1i2 interacts with 133 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process drug export, exogenous drug catabolic process, ...
Component nucleus
Function DNA binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (60)    Tissues (39)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nr1i2 ; ZFIN nr1i2    NEW 
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(15)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023687 (Evidence)
Ensembl Gene Model ENSMUSG00000022809 (Evidence)
Entrez Gene 18171 (Evidence)
UniGene 8509
DFCI TC1585950
DoTS DT.60101067, DT.91338829
NIA Mouse Gene Index U037034
Consensus CDS Project CCDS28164.1
International Mouse Phenotyping Consortium Status Nr1i2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023687 VEGA Gene Model | MGI Sequence Detail 46502 C57BL/6J ±  kb
transcript OTTMUST00000057839 VEGA | MGI Sequence Detail 2553 Not Applicable 
polypeptide OTTMUSP00000027962 VEGA | MGI Sequence Detail 431 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(15) UniProt(3)
Polymorphisms
SNPs within 2kb(228 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001723 Nuclear hormone receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011397 nuclear receptor subfamily 1 group I member 2
References
(Earliest) J:50706 Bertilsson G, et al., Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12208-13
(Latest) J:215352 Luisier R, et al., Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors. Toxicol Sci. 2014 Jun;139(2):501-11
All references(110)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory