Sequence Detail

ID/Version

O54915 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Nuclear receptor subfamily 1 group I member 2;AltName: Full=Orphan nuclear receptor PXR;AltName: Full=Pregnane X receptor;

Provider

SWISS-PROT

Sequence

Polypeptide 431 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr1i2	nuclear receptor subfamily 1, group I, member 2	40	104	3	20

Sequence references in MGI

J:51034 Kliewer SA, et al., An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 1998 Jan 9;92(1):73-82
J:81824 Dussault I, et al., Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):833-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:244975 Kriebs A, et al., Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781