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Prkag2 Gene Detail
Summary
  • Symbol
    Prkag2
  • Name
    protein kinase, AMP-activated, gamma 2 non-catalytic subunit
  • Synonyms
    2410051C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336153
    NCBI Gene: 108099
Location & Maps
more
  • Sequence Map
    Chr5:24862744-25100642 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      237899 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRKAG2, protein kinase AMP-activated non-catalytic subunit gamma 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKAG2, protein kinase AMP-activated non-catalytic subunit gamma 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AAKG, AAKG2, CMH6, H91620p, WPWS
  • Links
    NCBI Gene ID: 51422
    neXtProt AC: NX_Q9UGJ0

  • Chr Location
    7q36.1; chr7:151556114-151877231 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human PRKAG2 associations

Human Disease Mouse Models
       Cardiomyopathy, Familial Hypertrophic, 6; CMH6   OMIM: 600858 View 1 model
Glycogen Storage Disease of Heart, Lethal Congenital   OMIM: 261740 View 2 models
Wolff-Parkinson-White Syndrome   OMIM: 194200 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from multigenic genotypes
    22 phenotype references
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    2
  • Gene trapped
    8
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    2
  • Transgenic
    7
  • Genomic Mutations
    5 involving Prkag2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023541 VEGA Gene Model | MGI Sequence Detail 237899 C57BL/6J ±  kb
transcript OTTMUST00000057395 VEGA | MGI Sequence Detail 3331 Not Applicable  
polypeptide OTTMUSP00000027683 VEGA | MGI Sequence Detail 566 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2493 from dbSNP Build 137
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000013226 5'-AMP-activated protein kinase subunit gamma-2
  • InterPro Domains
    IPR000644 CBS domain
Molecular
Reagents
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  • All nucleic 23
    cDNA 13
    Primer pair 10

    Microarray probesets 9
Other
Accession IDs
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MGI:1920950, MGI:2141005
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Diseases 6
    Gene Ontology 4
    Phenotypes 22
  • Earliest
    J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
  • Latest
    J:186631 Pinter K, et al., Embryonic expression of AMPK gamma subunits and the identification of a novel gamma2 transcript variant in adult heart. J Mol Cell Cardiol. 2012 Sep;53(3):342-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory