Phenotypes Associated with This Genotype

Genotype
MGI:8187632

• Allelic Composition: Prkag2^tm2.1Mrl/?
• Genetic Background: C57BL/6-Prkag2^tm2.1Mrl/Tac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:237375 )

• mice fed a chow diet develop cardiac hypertrophy at 24 weeks of age

• feeding a high-fat diet does not worsen cardiac function

abnormal sinus arrhythmia ( J:237375 )

decreased heart rate ( J:237375 )

• 50% of mice exhibit bradycardia

shortened RR interval ( J:237375 )

• mice under anesthetized conditions have a shortened RR intervals

ventricular premature beat ( J:237375 )

• occasional premature ventricular contraction

shortened PR interval ( J:237375 )

• mice under anesthetized conditions have a shortened PR interval

shortened PQ interval ( J:237375 )

• mice under anesthetized conditions have a shorter PQ interval, a feature of pre-excitation

• however, the QRS complex appears normal

growth/size/body

cardiac hypertrophy ( J:237375 )

• mice fed a chow diet develop cardiac hypertrophy at 24 weeks of age

• feeding a high-fat diet does not worsen cardiac function

decreased susceptibility to diet-induced obesity ( J:237375 )

• mice gain less weight than wild-type mice when fed a high-fat diet, with fat mass 44% lower at 20 weeks of age

• however, mice exhibit normal body weight and body weight gain on a chow diet

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:237375 )

• mice gain less weight than wild-type mice when fed a high-fat diet, with fat mass 44% lower at 20 weeks of age

• however, mice exhibit normal body weight and body weight gain on a chow diet

decreased circulating cholesterol level ( J:237375 )

• plasma cholesterol levels are lower in mice on a high-fat diet under fed conditions

decreased circulating free fatty acids level ( J:237375 )

• plasma free fatty acid levels are lower in mice on a high-fat diet under fed conditions

decreased circulating triglyceride level ( J:237375 )

• plasma levels of triglycerides are lower in mice on a high-fat diet under fed conditions

improved glucose tolerance ( J:237375 )

• mice fed a high-fat diet show improved glucose tolerance

• however, mice show normal glucose tolerance on a chow diet

increased skeletal muscle glycogen level ( J:237375 )

• glycogen content in skeletal muscle is increased on high-fat diet and shows a trend toward increase on chow diet

• however, cardiac glycogen levels are unchanged in mice fed with either chow or high-fat diet

increased insulin sensitivity ( J:237375 )

• mice fed a high-fat diet show improved insulin tolerance

• however, mice show normal insulin tolerance on a chow diet

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:237375 )

• mice are protected from developing liver steatosis after high-fat diet feeding

muscle

increased skeletal muscle glycogen level ( J:237375 )

• glycogen content in skeletal muscle is increased on high-fat diet and shows a trend toward increase on chow diet

• however, cardiac glycogen levels are unchanged in mice fed with either chow or high-fat diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Wolff-Parkinson-White syndrome		DOID:384	OMIM:194200	J:237375