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Mbd2 Gene Detail
Summary
  • Symbol
    Mbd2
  • Name
    methyl-CpG binding domain protein 2
  • Synonyms
    MBD2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333813
    NCBI Gene: 17191
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:70701260-70759202 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 44.54 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333813
 protein coding gene Chr18:70701260-70761769 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024545
 protein coding gene Chr18:71046993-71106596 (+)
A/J MGP_AJ_G0024512
 protein coding gene Chr18:67930617-67989604 (+)
AKR/J MGP_AKRJ_G0024483
 protein coding gene Chr18:69944362-70002063 (+)
BALB/cJ MGP_BALBcJ_G0024512
 protein coding gene Chr18:68101510-68159672 (+)
C3H/HeJ MGP_C3HHeJ_G0024280
 protein coding gene Chr18:70043345-70103514 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024958
 protein coding gene Chr18:72874640-72933949 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022389
 protein coding gene Chr18:67215995-67272199 (+)
CAST/EiJ MGP_CASTEiJ_G0023753
 protein coding gene Chr18:70151032-70214087 (+)
CBA/J MGP_CBAJ_G0024249
 protein coding gene Chr18:75368726-75432817 (+)
DBA/2J MGP_DBA2J_G0024379
 protein coding gene Chr18:67558160-67616299 (+)
FVB/NJ MGP_FVBNJ_G0024345
 protein coding gene Chr18:66913427-66971137 (+)
LP/J MGP_LPJ_G0024463
 protein coding gene Chr18:70900288-70961546 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024375
 protein coding gene Chr18:76614969-76675336 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025006
 protein coding gene Chr18:70103443-70161023 (+)
PWK/PhJ MGP_PWKPhJ_G0023497
 protein coding gene Chr18:67912584-67970729 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023301
 protein coding gene Chr18:70228367-70285399 (+)
WSB/EiJ MGP_WSBEiJ_G0023816
 protein coding gene Chr18:70037383-70097409 (+)



Homology
more
  • Human Ortholog
    MBD2, methyl-CpG binding domain protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MBD2, methyl-CpG binding domain protein 2
  • Synonyms
    DMTase, NY-CO-41
  • Links
    NCBI Gene ID: 8932
    neXtProt AC: NX_Q9UBB5
    UniProt: Q9UBB5

  • Chr Location
    18q21.2; chr18:54151601-54224788 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Mbd2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruption sin this gene are grossly normal. Maternal nurturing problems exist however and they are somewhat resistant to dumor development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1162
  • Tissues
    388
  • cDNA Data
    100
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024513 Ensembl Gene Model | MGI Sequence Detail 57943 C57BL/6J ±  kb
    transcript ENSMUST00000074058 Ensembl | MGI Sequence Detail 1953 Not Applicable  
    polypeptide ENSMUSP00000073701 Ensembl | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 101
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 14
      Phenotypes 29
    • Earliest
      J:50520 Hendrich B, et al., Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47
    • Latest
      J:323838 Yue T, et al., MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-gamma axis. Cell Death Differ. 2022 Jan;29(1):218-229
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/23/2022
    MGI 6.20     		The Jackson Laboratory