Mbd2
Gene Detail

Symbol Name ID

Mbd2 methyl-CpG binding domain protein 2 MGI:1333813

Synonyms

MBD2a

Feature Type

protein coding gene

Genetic Map

Chromosome 18

44.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr18:70568189-70626131 bp, + strand From VEGA annotation of GRCm38   57943 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2918  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mbd2

Human homologs

Human Homolog		MBD2, methyl-CpG binding domain protein 2
NCBI Gene ID		8932
neXtProt AC		NX_Q9UBB5
Human Synonyms		DMTase, NY-CO-41
Human Chr (Location)		18q21; chr18:54151601-54224788 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(8) : Gene trapped(4) Targeted(4)
 

Mice homozygous for disruption sin this gene are grossly normal. Maternal nurturing problems exist however and they are somewhat resistant to dumor development.

 

Interactions

Mbd2 interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	ATP-dependent chromatin remodeling, cellular protein complex assembly, ...
Component	chromatin, cytoplasm, ...
Function	C2H2 zinc finger domain binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)

Data Summary: Results (394)    Tissues (331)    Images (28)
Theiler Stages: 1, 2, 3, 4, 15, 17, 19, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	350
RT-PCR	44

cDNA source data(98)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular reagents

All nucleic(102) cDNA(99) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000027673 (Evidence)
Ensembl Gene Model	ENSMUSG00000024513 (Evidence)
Entrez Gene	17191 (Evidence)
UniGene	322
DFCI	TC1576710, TC1593547, TC1611101, TC1768170
DoTS	DT.101714202, DT.110762794, DT.533873, DT.91376106
NIA Mouse Gene Index	U018874, U350571
Consensus CDS Project	CCDS29335.1
International Mouse Knockout Project Status	Mbd2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027673	VEGA Gene Model | MGI Sequence Detail	57943	C57BL/6J
transcript	OTTMUST00000068474	VEGA | MGI Sequence Detail	1953	Not Applicable
polypeptide	OTTMUSP00000034632	VEGA | MGI Sequence Detail	414	Not Applicable

All sequences(58) RefSeq(9) UniProt(3)

Polymorphisms

PCR(1) : SNPs within 2kb(255 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR016177	DNA-binding, integrase-type
InterPro	IPR025884	Methyl-CpG binding protein 2/3, C-terminal domain
InterPro	IPR001739	Methyl-CpG DNA binding
Protein Ontology	PR:000010215	methyl-CpG-binding domain protein 2

References

(Earliest) J:50520 Hendrich B, et al., Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47
(Latest) J:205427 Wang L, et al., Mbd2 promotes foxp3 demethylation and T-regulatory-cell function. Mol Cell Biol. 2013 Oct;33(20):4106-15
All references(67)