Mbd2 MGI Mouse Gene Detail - MGI:1333813 - methyl-CpG binding domain protein 2

Symbol

Mbd2
Name

methyl-CpG binding domain protein 2
Synonyms

MBD2a

Feature Type

protein coding gene
IDs

MGI:1333813
NCBI Gene: 17191
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr18:70701260-70759202 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 44.54 cM
Mapping Data

6 experiments

SNPs within 2kb

245 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333813	protein coding gene	Chr18:70701260-70761769 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024545	protein coding gene	Chr18:71046993-71106596 (+)
A/J	MGP_AJ_G0024512	protein coding gene	Chr18:67930617-67989604 (+)
AKR/J	MGP_AKRJ_G0024483	protein coding gene	Chr18:69944362-70002063 (+)
BALB/cJ	MGP_BALBcJ_G0024512	protein coding gene	Chr18:68101510-68159672 (+)
C3H/HeJ	MGP_C3HHeJ_G0024280	protein coding gene	Chr18:70043345-70103514 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024958	protein coding gene	Chr18:72874640-72933949 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022389	protein coding gene	Chr18:67215995-67272199 (+)
CAST/EiJ	MGP_CASTEiJ_G0023753	protein coding gene	Chr18:70151032-70214087 (+)
CBA/J	MGP_CBAJ_G0024249	protein coding gene	Chr18:75368726-75432817 (+)
DBA/2J	MGP_DBA2J_G0024379	protein coding gene	Chr18:67558160-67616299 (+)
FVB/NJ	MGP_FVBNJ_G0024345	protein coding gene	Chr18:66913427-66971137 (+)
LP/J	MGP_LPJ_G0024463	protein coding gene	Chr18:70900288-70961546 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024375	protein coding gene	Chr18:76614969-76675336 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025006	protein coding gene	Chr18:70103443-70161023 (+)
PWK/PhJ	MGP_PWKPhJ_G0023497	protein coding gene	Chr18:67912584-67970729 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023301	protein coding gene	Chr18:70228367-70285399 (+)
WSB/EiJ	MGP_WSBEiJ_G0023816	protein coding gene	Chr18:70037383-70097409 (+)

Human Ortholog

MBD2, methyl-CpG binding domain protein 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MBD2, methyl-CpG binding domain protein 2
Synonyms

DMTase, NY-CO-41
Links

HGNC:6917

NCBI Gene ID: 8932

neXtProt AC: NX_Q9UBB5

UniProt: Q9UBB5
Chr Location

18q21.2; chr18:54151601-54224788 (-) GRCh38.p7

Alliance of Genome Resources

Mbd2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: MBD2
Gene Tree

Mbd2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

4
Targeted

5
Incidental Mutations

CvDC
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for disruption sin this gene are grossly normal. Maternal nurturing problems exist however and they are somewhat resistant to dumor development.

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All GO Annotations

26
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1121
Tissues

388
cDNA Data

100
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mbd2

ZFIN mbd2

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Mbd2 interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

55
RefSeq

9
UniProt

3
CCDS

CCDS29335.1, CCDS79661.1

Ensembl

ENSMUSG00000024513 (Evidence)
NCBI Gene

17191

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024513	Ensembl Gene Model \| MGI Sequence Detail	57943	C57BL/6J	± kb
transcript	ENSMUST00000074058	Ensembl \| MGI Sequence Detail	1953	Not Applicable
polypeptide	ENSMUSP00000073701	Ensembl \| MGI Sequence Detail	414	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010215 methyl-CpG-binding domain protein 2

(term hierarchy)
InterPro Domains

IPR016177 DNA-binding domain superfamily

IPR032343 Methyl-CpG-binding domain protein 2/3, p55-binding region

IPR037965 Methyl-CpG-binding domain protein 3

IPR025884 Methyl-CpG binding protein 2/3, C-terminal domain

IPR001739 Methyl-CpG DNA binding

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All nucleic 104

cDNA 101

Primer pair 3

Microarray probesets 4

Summaries

All 86

Developmental Gene Expression 13

Gene Ontology 11

Phenotypes 25
Earliest

J:50520 Hendrich B, et al., Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47
Latest

J:302123 Cheng L, et al., Loss of MBD2 affects early T cell development by inhibiting the WNT signaling pathway. Exp Cell Res. 2021 Jan 1;398(1):112400

TSS for Mbd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151867	Chr18:70701339-70701469 (+)	144 bp
Tssr151868	Chr18:70701497-70701577 (+)	277 bp
Tssr151869	Chr18:70701932-70701969 (+)	691 bp
Tssr151870	Chr18:70701970-70702013 (+)	732 bp
Tssr151871	Chr18:70713769-70713804 (+)	12,527 bp
Tssr151872	Chr18:70714131-70714136 (+)	12,874 bp
Tssr151874	Chr18:70754754-70754758 (+)	53,496 bp
Tssr151875	Chr18:70755664-70755694 (+)	54,419 bp
Tssr151876	Chr18:70755696-70755716 (+)	54,446 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/08/2021 MGI 6.17