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Mbd2
Gene Detail
Symbol

Name
ID
Mbd2
methyl-CpG binding domain protein 2
MGI:1333813
Synonyms
MBD2a
Feature Type
protein coding gene
Genetic Map
Chromosome 18
44.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr18:70568189-70626131 bp, + strand
From VEGA annotation of GRCm38

  57943 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2918  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: MBD2
Gene Tree: Mbd2

Human
homologs
MBD2, methyl-CpG binding domain protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8932
neXtProt AC: NX_Q9UBB5

Human Synonyms: DMTase, NY-CO-41

Human Chr (Location): 18q21; chr18:54151601-54224788 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from CvDC )
 
Mice homozygous for disruption sin this gene are grossly normal. Maternal nurturing problems exist however and they are somewhat resistant to dumor development.
 
Interactions
Mbd2 interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process ATP-dependent chromatin remodeling, cellular protein complex assembly, ...
Component chromatin, cytoplasm, ...
Function C2H2 zinc finger domain binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (390)    Tissues (328)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 350
RT-PCR 40
cDNA source data(98)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mbd2 ; ZFIN mbd2    NEW 
Molecular
reagents
All nucleic(102) cDNA(99) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027673 (Evidence)
Ensembl Gene Model ENSMUSG00000024513 (Evidence)
Entrez Gene 17191 (Evidence)
UniGene 322
DFCI TC1576710, TC1593547, TC1611101, TC1768170
DoTS DT.101714202, DT.110762794, DT.533873, DT.91376106
NIA Mouse Gene Index U018874, U350571
Consensus CDS Project CCDS29335.1, CCDS79661.1
International Mouse Phenotyping Consortium Status Mbd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027673 VEGA Gene Model | MGI Sequence Detail 57943 C57BL/6J ±  kb
transcript OTTMUST00000068474 VEGA | MGI Sequence Detail 1953 Not Applicable 
polypeptide OTTMUSP00000034632 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(9) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016177 DNA-binding domain
InterPro IPR025884 Methyl-CpG binding protein 2/3, C-terminal domain
InterPro IPR001739 Methyl-CpG DNA binding
Protein Ontology PR:000010215 methyl-CpG-binding domain protein 2
References
(Earliest) J:50520 Hendrich B, et al., Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47
(Latest) J:216329 Hum JM, et al., Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression. PLoS One. 2014;9(5):e97942
All references(71)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory