Mbd2 MGI Mouse Gene Detail - MGI:1333813 - methyl-CpG binding domain protein 2

Mbd2 Gene Detail

Symbol

Mbd2
Name

methyl-CpG binding domain protein 2
Synonyms

MBD2a

Feature Type

protein coding gene
IDs

MGI:1333813
NCBI Gene: 17191

Sequence Map

Chr18:70568189-70626131 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

57943 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 44.54 cM
Mapping Data

6 experiments

Human Ortholog

MBD2, methyl-CpG binding domain protein 2

Vertebrate Orthologs

9

Human Ortholog

MBD2, methyl-CpG binding domain protein 2
Orthology source: HomoloGene, HGNC
Synonyms

DMTase, NY-CO-41
Links

HGNC:6917

NCBI Gene ID: 8932

neXtProt AC: NX_Q9UBB5

UniProt: Q9UBB5
Chr Location

18q21.2; chr18:54151601-54224788 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2918
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: MBD2
Gene Tree

Mbd2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

4
Targeted

4
Incidental Mutations

CvDC
Find Mice (IMSR)

11 strains or lines available

Mice homozygous for disruption sin this gene are grossly normal. Maternal nurturing problems exist however and they are somewhat resistant to dumor development.

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All GO Annotations

37
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

490
Tissues

388
cDNA Data

99
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN mbd2

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Mbd2 interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

45
RefSeq

9
UniProt

3
CCDS

CCDS29335.1, CCDS79661.1
UniGene

322

			Length	Strain/Species	Flank
genomic	OTTMUSG00000027673	VEGA Gene Model \| MGI Sequence Detail	57943	C57BL/6J	± kb
transcript	OTTMUST00000068474	VEGA \| MGI Sequence Detail	1953	Not Applicable
polypeptide	OTTMUSP00000034632	VEGA \| MGI Sequence Detail	414	Not Applicable

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SNPs within 2kb

255 from dbSNP Build 142

PCR

1

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UniProt

3 Sequences
Protein Ontology

PR:000010215 methyl-CpG-binding domain protein 2

(term hierarchy)
InterPro Domains

IPR016177 DNA-binding domain

IPR032343 Methyl-CpG-binding domain protein 2/3, p55-binding region

IPR025884 Methyl-CpG binding protein 2/3, C-terminal domain

IPR001739 Methyl-CpG DNA binding

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All nucleic 104

cDNA 100

Primer pair 4

Microarray probesets 4

Summaries

All 72

Developmental Gene Expression 12

Gene Ontology 14

Phenotypes 19
Earliest

J:50520 Hendrich B, et al., Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47
Latest

J:231640 Desai MA, et al., An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex. Nucleic Acids Res. 2015 Mar 31;43(6):3100-13

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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