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Mbd2 Gene Detail
Summary
  • Symbol
    Mbd2
  • Name
    methyl-CpG binding domain protein 2
  • Synonyms
    MBD2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333813
    NCBI Gene: 17191
Location & Maps
more
  • Sequence Map
    Chr18:70568189-70626131 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57943 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MBD2, methyl-CpG binding domain protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MBD2, methyl-CpG binding domain protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DMTase, NY-CO-41
  • Links
    NCBI Gene ID: 8932
    neXtProt AC: NX_Q9UBB5

  • Chr Location
    18q21; chr18:54151601-54224788 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    4
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for disruption sin this gene are grossly normal. Maternal nurturing problems exist however and they are somewhat resistant to dumor development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027673 VEGA Gene Model | MGI Sequence Detail 57943 C57BL/6J ±  kb
transcript OTTMUST00000068474 VEGA | MGI Sequence Detail 1953 Not Applicable  
polypeptide OTTMUSP00000034632 VEGA | MGI Sequence Detail 414 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    255 from dbSNP Build 137
  • PCR
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010215 methyl-CpG-binding domain protein 2
  • InterPro Domains
    IPR016177 DNA-binding domain
    IPR032343 Methyl-CpG-binding domain protein 2/3, p55-binding region
    IPR025884 Methyl-CpG binding protein 2/3, C-terminal domain
    IPR001739 Methyl-CpG DNA binding
Molecular
Reagents
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  • All nucleic 102
    cDNA 99
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 69
    Developmental Gene Expression 12
    Gene Ontology 14
    Phenotypes 19
  • Earliest
    J:50520 Hendrich B, et al., Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47
  • Latest
    J:222798 Cook PC, et al., A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells. Nat Commun. 2015;6:6920

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory