About   Help   FAQ
Soat2
Gene Detail
 Symbol
Name
ID
Soat2
sterol O-acyltransferase 2
MGI:1332226
Synonyms ACAT2, D15Wsu97e
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:102150526-102163474 bp, + strand
From VEGA annotation of GRCm38

  12949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68355  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: sterol O-acyltransferase, ACAT/DAG/ARE types
Gene Tree: Soat2

Human
homologs
Human Homolog SOAT2, sterol O-acyltransferase 2
NCBI Gene ID 8435
neXtProt AC  NX_O75908
Human Synonyms  ACACT2, ACAT2, ARGP2
Human Chr (Location)  12q13.13; chr12:53103490-53124539 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(17) Radiation induced(1) Targeted(6)
Genomic Mutations involving Soat2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant animals exhibit elevated serum triglyceride levels and are resistant to fatty liver, hyperlipidemia, and gallstone development when fed a high fat, high cholesterol diet. When fed a Western diet homozygous mutant animals exhibit elevated HDL levels.
 
Interactions
Soat2 interacts with 122 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cholesterol efflux, cholesterol esterification, ...
Component brush border, endoplasmic reticulum, ...
Function cholesterol binding, cholesterol O-acyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (100)    Tissues (96)   
Theiler Stages: 11, 22
Assay TypeResults
RNA in situ 94
RT-PCR 6
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035013 (Evidence)
Ensembl Gene ModelENSMUSG00000023045 (Evidence)
Entrez Gene223920 (Evidence)
UniGene358862
DFCITC1586850
DoTSDT.50314933
NIA Mouse Gene IndexU016699
EC2.3.1.26
Consensus CDS ProjectCCDS27872.1
International Mouse Knockout Project StatusSoat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035013 VEGA Gene Model | MGI Sequence Detail 12949 C57BL/6J ±  kb
transcript OTTMUST00000089028 VEGA | MGI Sequence Detail 2213 Not Applicable 
polypeptide OTTMUSP00000048596 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
InterPro IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types
Protein Ontology PR:000015390 sterol O-acyltransferase 2
References (Earliest) J:45730 Cases S, et al., ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem. 1998 Oct 9;273(41):26755-64
(Latest) J:200774 Melchior JT, et al., LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis. J Lipid Res. 2013 Sep;54(9):2495-503
All references(55)
Other
accession IDs
MGD-MRK-34003, MGI:106311

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory