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Soat2
Gene Detail
Symbol

Name
ID
Soat2
sterol O-acyltransferase 2
MGI:1332226
Synonyms
ACAT2, D15Wsu97e
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:102150526-102163474 bp, + strand
From VEGA annotation of GRCm38

  12949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68355  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 western clawed frog

HCOP human homology predictions: SOAT2
Protein SuperFamily: sterol O-acyltransferase, ACAT/DAG/ARE types
Gene Tree: Soat2

Human
homologs
SOAT2, sterol O-acyltransferase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8435
neXtProt AC: NX_O75908

Human Synonyms: ACACT2, ACAT2, ARGP2

Human Chr (Location): 12q13.13; chr12:53102504-53124539 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(17) Radiation induced(1) Targeted(6)
Genomic Mutations involving Soat2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant animals exhibit elevated serum triglyceride levels and are resistant to fatty liver, hyperlipidemia, and gallstone development when fed a high fat, high cholesterol diet. When fed a Western diet homozygous mutant animals exhibit elevated HDL levels.
 
Phenotype Images(2)
Interactions
Soat2 interacts with 122 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cholesterol efflux, cholesterol esterification, ...
Component brush border, endoplasmic reticulum, ...
Function cholesterol binding, cholesterol O-acyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (100)    Tissues (96)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 6
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase soat2    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035013 (Evidence)
Ensembl Gene Model ENSMUSG00000023045 (Evidence)
Entrez Gene 223920 (Evidence)
UniGene 358862
DFCI TC1586850
DoTS DT.50314933
NIA Mouse Gene Index U016699
EC 2.3.1.26
Consensus CDS Project CCDS27872.1
International Mouse Phenotyping Consortium Status Soat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035013 VEGA Gene Model | MGI Sequence Detail 12949 C57BL/6J ±  kb
transcript OTTMUST00000089028 VEGA | MGI Sequence Detail 2213 Not Applicable 
polypeptide OTTMUSP00000048596 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
InterPro IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types
Protein Ontology PR:000015390 sterol O-acyltransferase 2
References
(Earliest) J:45730 Cases S, et al., ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem. 1998 Oct 9;273(41):26755-64
(Latest) J:220279 Lopez AM, et al., Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver. Biochem Biophys Res Commun. 2014 Nov 7;454(1):162-6
All references(57)
Other
accession IDs
MGD-MRK-34003, MGI:106311

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory