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Dkk1 Gene Detail
Summary
  • Symbol
    Dkk1
  • Name
    dickkopf WNT signaling pathway inhibitor 1
  • Synonyms
    mdkk-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329040
    NCBI Gene: 13380
  • Gene Overview
    MyGene.info: DKK1
Location & Maps
more
  • Sequence Map
    Chr19:30545863-30549665 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3803 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 25.16 cM, cytoband C2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DKK1, dickkopf WNT signaling pathway inhibitor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DKK1, dickkopf WNT signaling pathway inhibitor 1
    Orthology source: HomoloGene
  • Synonyms
    DKK-1, SK
  • Links
    NCBI Gene ID: 22943
    neXtProt AC: NX_O94907

  • Chr Location
    10q11.2; chr10:52314281-52317657 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 5 alleles in 6 genetic backgrounds
    19 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation die at birth exhibiting absence of anterior head structures and forelimb malformations ranging from fusion of the distal-most limb elements to the appearance of ectopic preaxial and postaxial digits.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020350 VEGA Gene Model | MGI Sequence Detail 3803 C57BL/6J ±  kb
transcript OTTMUST00000048273 VEGA | MGI Sequence Detail 2427 Not Applicable  
polypeptide OTTMUSP00000022079 VEGA | MGI Sequence Detail 272 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006499 dickkopf-related protein 1
  • InterPro Domains
    IPR006796 Dickkopf, N-terminal cysteine-rich
Molecular
Reagents
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  • All nucleic 35
    cDNA 16
    Primer pair 10
    Other 9

    Microarray probesets 3
References
more
  • Summaries
    All 227
    Developmental Gene Expression 152
    Gene Ontology 28
    Phenotypes 36
  • Earliest
    J:51745 Glinka A, et al., Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature. 1998 Jan 22;391(6665):357-62
  • Latest
    J:231594 Kumar M, et al., Epithelial Wnt/betacatenin signalling is essential for epididymal coiling. Dev Biol. 2016 Apr 15;412(2):234-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory