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Edil3 Gene Detail
Summary
  • Symbol
    Edil3
  • Name
    EGF-like repeats and discoidin I-like domains 3
  • Synonyms
    Del1, Del-1, developmental endothelial locus-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329025
    NCBI Gene: 13612
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:88821472-89323223 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 45.30 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329025
protein coding gene Chr13:88821472-89323225 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020798
protein coding gene Chr13:89919712-90464646 (+)
A/J MGP_AJ_G0020752
protein coding gene Chr13:86614237-87110706 (+)
AKR/J MGP_AKRJ_G0020725
protein coding gene Chr13:89250728-89770650 (+)
BALB/cJ MGP_BALBcJ_G0020748
protein coding gene Chr13:87270328-87776238 (+)
C3H/HeJ MGP_C3HHeJ_G0020542
protein coding gene Chr13:88997496-89516697 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021185
protein coding gene Chr13:92773148-93328766 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018753
protein coding gene Chr13:82704137-83187479 (+)
CAST/EiJ MGP_CASTEiJ_G0020060
protein coding gene Chr13:88125925-88682391 (+)
CBA/J MGP_CBAJ_G0020501
protein coding gene Chr13:96376949-96945672 (+)
DBA/2J MGP_DBA2J_G0020626
protein coding gene Chr13:86373184-86890566 (+)
FVB/NJ MGP_FVBNJ_G0020606
protein coding gene Chr13:85248184-85741268 (+)
LP/J MGP_LPJ_G0020699
protein coding gene Chr13:90094551-90620593 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020635
protein coding gene Chr13:96508432-97272170 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021225
protein coding gene Chr13:88661219-89181958 (+)
PWK/PhJ MGP_PWKPhJ_G0019813
protein coding gene Chr13:85098398-85623152 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019636
protein coding gene Chr13:84886375-85410417 (+)
WSB/EiJ MGP_WSBEiJ_G0020118
protein coding gene Chr13:89146702-89663514 (+)



Homology
more
  • Human Ortholog
    EDIL3, EGF like repeats and discoidin domains 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EDIL3, EGF like repeats and discoidin domains 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DEL1
  • Links
    NCBI Gene ID: 10085
    neXtProt AC: NX_O43854
    UniProt: O43854

  • Chr Location
    5q14.3; chr5:83940595-84384867 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    374 phenotypes from multigenic genotypes
    22 images
    322 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are viable and fertile with no noticeable fur phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034488 Ensembl Gene Model | MGI Sequence Detail 501752 C57BL/6J ±  kb
transcript ENSMUST00000081769 Ensembl | MGI Sequence Detail 5317 Not Applicable  
polypeptide ENSMUSP00000080462 Ensembl | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006896 EGF-like repeat and discoidin I-like domain-containing protein 3
  • InterPro Domains
    IPR000421 Coagulation factor 5/8 C-terminal domain
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR029828 EGF-like repeat and discoidin I-like domain-containing protein 3
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR008979 Galactose-binding-like domain superfamily
Molecular
Reagents
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  • All nucleic 27
    Genomic 2
    cDNA 21
    Primer pair 3
    Other 1

    Microarray probesets 10
Other
Accession IDs
less
MGI:2656537
References
more
  • Summaries
    All 351
    Developmental Gene Expression 8
    Diseases 5
    Gene Ontology 3
    Phenotypes 322
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:264384 Ramalingam H, et al., Disparate levels of beta-catenin activity determine nephron progenitor cell fate. Dev Biol. 2018 Aug 1;440(1):13-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory