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Edil3
Gene Detail
Symbol

Name
ID
Edil3
EGF-like repeats and discoidin I-like domains 3
MGI:1329025
Synonyms
Del1, Del-1, developmental endothelial locus-1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
45.30 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:88821472-89323223 bp, + strand
From VEGA annotation of GRCm38

  501752 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21166  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EDIL3
Protein SuperFamily: lactadherin-like protein
Gene Tree: Edil3

Human
homologs
EDIL3, EGF-like repeats and discoidin I-like domains 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10085
neXtProt AC: NX_O43854

Human Synonyms: DEL1

Human Chr (Location): 5q14; chr5:83940595-84384867 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation are viable and fertile with no noticeable fur phenotype.
 
Interactions
Edil3 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell adhesion, multicellular organismal development, ...
Component extracellular exosome, extracellular region, ...
Function calcium ion binding, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (20)    Tissues (11)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
RT-PCR 8
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase edil3    NEW 
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(21) Primer pair(3) Other(1)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000027759 (Evidence)
Ensembl Gene Model ENSMUSG00000034488 (Evidence)
Entrez Gene 13612 (Evidence)
DFCI TC1581996, TC1592204, TC1598798, TC1606701, TC1627255, TC1640086, TC1727069
DoTS DT.110977052, DT.55111976, DT.55123024, DT.55222259, DT.91335447, DT.91481851
NIA Mouse Gene Index U015083
Consensus CDS Project CCDS26669.1, CCDS26670.1
International Mouse Phenotyping Consortium Status Edil3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027759 VEGA Gene Model | MGI Sequence Detail 501752 C57BL/6J ±  kb
transcript OTTMUST00000068691 VEGA | MGI Sequence Detail 5317 Not Applicable 
polypeptide OTTMUSP00000034781 VEGA | MGI Sequence Detail 480 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(4215 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4217)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal domain
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR001881 EGF-like calcium-binding domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR029828 EGF-like repeat and discoidin I-like domain-containing protein 3
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR008979 Galactose-binding domain-like
Protein Ontology PR:000006896 EGF-like repeat and discoidin I-like domain-containing protein 3
References
(Earliest) J:45380 Hidai C, et al., Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. Genes Dev. 1998 Jan 1;12(1):21-33
(Latest) J:219144 Kang YY, et al., Deficiency of developmental endothelial locus-1 (Del-1) aggravates bleomycin-induced pulmonary fibrosis in mice. Biochem Biophys Res Commun. 2014 Mar 7;445(2):369-74
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory