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Slc40a1
Gene Detail
Symbol

Name
ID
Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
MGI:1315204
Synonyms
Dusg, ferroportin1, FPN1, IREG1, metal transporting protein 1, MTP1, Ol5, Pcm, Slc11a3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
23.96 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:45908068-45926523 bp, - strand
From VEGA annotation of GRCm38

  18456 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40959  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC40A1
Gene Tree: Slc40a1

Human
homologs
SLC40A1, solute carrier family 40 (iron-regulated transporter), member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 30061
neXtProt AC: NX_Q9NP59

Human Synonyms: FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3

Human Chr (Location): 2q32; chr2:189560590-189580811 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC40A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit embryonic lethality before embryo turning. Mice heterozygous for a targeted mutation display decreased thermal response latency. Mice heterozygous for an ENU induced mutation display abnormal iron homeostasis.
 
Human Diseases Modeled in Mice Using Slc40a1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Slc40a1 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (319)    Tissues (124)    Images (108)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 156
In situ reporter (knock in) 114
RT-PCR 42
cDNA source data(61)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc40a1 ; ZFIN slc40a1    NEW 
Molecular
reagents
All nucleic(66) Genomic(1) cDNA(62) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000046528 (Evidence)
Ensembl Gene Model ENSMUSG00000025993 (Evidence)
Entrez Gene 53945 (Evidence)
UniGene 28756
DFCI TC1575067, TC1595031, TC1608205
DoTS DT.101377678, DT.110898319, DT.532379
NIA Mouse Gene Index U021297
Consensus CDS Project CCDS14933.1
International Mouse Phenotyping Consortium Status Slc40a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046528 VEGA Gene Model | MGI Sequence Detail 18456 C57BL/6J ±  kb
transcript OTTMUST00000121040 VEGA | MGI Sequence Detail 3370 Not Applicable 
polypeptide OTTMUSP00000066830 VEGA | MGI Sequence Detail 570 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(277 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009716 Ferroporti-1
InterPro IPR020846 Major facilitator superfamily domain
Protein Ontology PR:000015138 solute carrier family 40 member 1
References
(Earliest) J:30568 Cattanach BM, A new a mutation/ A dominant polycythaemia. Mouse Genome. 1995;93(4):1026-1029
(Latest) J:222047 Guida C, et al., A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia. Blood. 2015 Apr 2;125(14):2265-75
All references(84)
Disease annotation references (3)
Other
accession IDs
MGI:1860151, MGI:700182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory