Slc40a1
Gene Detail

Symbol Name ID

Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 MGI:1315204

Synonyms

Dusg, ferroportin1, FPN1, IREG1, metal transporting protein 1, MTP1, Ol5, Pcm, Slc11a3

Feature Type

protein coding gene

Genetic Map

Chromosome 1

23.96 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:45908070-45925594 bp, - strand From NCBI annotation of GRCm38   17525 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc40a1 ± 2 cM)

Gene Tree: Slc40a1

Human ortholog

SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 NCBI Gene ID 30061
Human Synonyms: FPN1, HFE4, IREG1, MST079, MTP1, SLC11A3
Human Chr2:190425316-190445537 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SLC40A1 (1)

Alleles and phenotypes

All alleles(6) : Targeted(4) Chemically induced(1) Radiation induced(1)
 

Mice homozygous for a targeted mutation exhibit embryonic lethality before embryo turning. Mice heterozygous for a targeted mutation display decreased thermal response latency. Mice heterozygous for an ENU induced mutation display abnormal iron homeostasis.

 
Human Diseases Modeled Using Mouse Slc40a1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	apoptotic process, cellular iron ion homeostasis, ...
Component	integral to membrane, membrane, ...
Function	iron ion transmembrane transporter activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (319)    Tissues (125)    Images (108)
Theiler Stages: 10, 15, 23, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	156
In situ reporter (knock in)	114
RT-PCR	42

cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) Genomic(1) cDNA(61) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000025993 (Evidence)
Entrez Gene	53945 (Evidence)
UniGene	28756
DFCI	TC1575067, TC1595031, TC1608205
DoTS	DT.101377678, DT.110898319, DT.532379
NIA Mouse Gene Index	U021297
Consensus CDS Project	CCDS14933.1
International Mouse Knockout Project Status	Slc40a1

Sequences

Length	Strain/Species
genomic	53945	NCBI Gene Model | MGI Sequence Detail	17525	C57BL/6J
transcript	NM_016917	RefSeq | MGI Sequence Detail	3380	C57BL/6
polypeptide	Q9JHI9	UniProt | EBI | MGI Sequence Detail	570	Not Applicable

All sequences(37) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(135 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009716	Ferroporti-1
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
Protein Ontology	PR:000015138	solute carrier family 40 member 1

Graphical View of Protein Domain Structure

References

(Earliest) J:30568 Cattanach BM, A new a mutation/ A dominant polycythaemia. Mouse Genome. 1995;93(4):1026-1029
(Latest) J:191755 Gabrielsen JS, et al., Adipocyte iron regulates adiponectin and insulin sensitivity. J Clin Invest. 2012 Oct 1;122(10):3529-40
All references(69)

Other accession IDs

MGI:1860151, MGI:700182