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Slc40a1 Gene Detail
Summary
  • Symbol
    Slc40a1
  • Name
    solute carrier family 40 (iron-regulated transporter), member 1
  • Synonyms
    Dusg, ferroportin1, FPN1, IREG1, metal transporting protein 1, MTP1, Ol5, Pcm, Slc11a3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315204
    NCBI Gene: 53945
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:45947228-45965683 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 23.96 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315204
protein coding gene Chr1:45947228-45965690 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015996
protein coding gene Chr1:44992735-45011143 (-)
A/J MGP_AJ_G0015980
protein coding gene Chr1:43590526-43609059 (-)
AKR/J MGP_AKRJ_G0015935
protein coding gene Chr1:44225788-44244307 (-)
BALB/cJ MGP_BALBcJ_G0015934
protein coding gene Chr1:43220049-43238395 (-)
C3H/HeJ MGP_C3HHeJ_G0015767
protein coding gene Chr1:44638555-44657087 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016387
protein coding gene Chr1:46869053-46888658 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014110
protein coding gene Chr1:40268690-40287321 (-)
CAST/EiJ MGP_CASTEiJ_G0015349
protein coding gene Chr1:44528389-44547553 (-)
CBA/J MGP_CBAJ_G0015739
protein coding gene Chr1:48200391-48221512 (-)
DBA/2J MGP_DBA2J_G0015840
protein coding gene Chr1:42868091-42886894 (-)
FVB/NJ MGP_FVBNJ_G0015842
protein coding gene Chr1:42324494-42342906 (-)
LP/J MGP_LPJ_G0015910
protein coding gene Chr1:45288390-45309134 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015862
protein coding gene Chr1:50327752-50348326 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016434
protein coding gene Chr1:44436753-44456423 (-)
PWK/PhJ MGP_PWKPhJ_G0015133
protein coding gene Chr1:42673117-42692122 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014915
protein coding gene Chr1:44447061-44466838 (-)
WSB/EiJ MGP_WSBEiJ_G0015410
protein coding gene Chr1:44410223-44429922 (-)



Homology
more
  • Human Ortholog
    SLC40A1, solute carrier family 40 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC40A1, solute carrier family 40 member 1
  • Synonyms
    FPN, FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3
  • Links
    NCBI Gene ID: 30061
    neXtProt AC: NX_Q9NP59
    UniProt: Q9NP59

  • Chr Location
    2q32.2; chr2:189560590-189583758 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Slc40a1 mouse models; 1 with human SLC40A1 associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 7 alleles in 9 genetic backgrounds
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit embryonic lethality before embryo turning. Mice heterozygous for a targeted mutation display decreased thermal response latency. Mice heterozygous for an ENU induced mutation display abnormal iron homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025993 Ensembl Gene Model | MGI Sequence Detail 18456 C57BL/6J ±  kb
    transcript ENSMUST00000027137 Ensembl | MGI Sequence Detail 3370 Not Applicable  
    polypeptide ENSMUSP00000027137 Ensembl | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 1
      cDNA 66
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1860151, MGI:700182
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 25
      Diseases 3
      Gene Ontology 17
      Phenotypes 61
    • Earliest
      J:49557 McKie AT, et al., Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption. Biochem Soc Trans. 1998 Aug;26(3):S264
    • Latest
      J:344175 Feng R, et al., Elevated SLC40A1 impairs cardiac function and exacerbates mitochondrial dysfunction, oxidative stress, and apoptosis in ischemic myocardia. Int J Biol Sci. 2024;20(2):414-432

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory