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Slc40a1
Gene Detail
 Symbol
Name
ID
Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
MGI:1315204
Synonyms Dusg, ferroportin1, FPN1, IREG1, metal transporting protein 1, MTP1, Ol5, Pcm, Slc11a3
Feature Type protein coding gene
Genetic Map
Chromosome 1
23.96 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:45908070-45925594 bp, - strand
From NCBI annotation of GRCm38

  17525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40959  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc40a1

Human
homologs
Human Homolog SLC40A1, solute carrier family 40 (iron-regulated transporter), member 1
NCBI Gene ID 30061
neXtProt AC  NX_Q9NP59
Human Synonyms  FPN1, HFE4, IREG1, MST079, MTP1, SLC11A3
Human Chr (Location)  2q32; chr2:189560590-189583752 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC40A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit embryonic lethality before embryo turning. Mice heterozygous for a targeted mutation display decreased thermal response latency. Mice heterozygous for an ENU induced mutation display abnormal iron homeostasis.
 
Human Diseases Modeled Using Mouse Slc40a1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc40a1 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cellular iron ion homeostasis, endothelium development, ...
Component basolateral plasma membrane, integral component of membrane, ...
Function iron ion transmembrane transporter activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (319)    Tissues (125)    Images (108)
Theiler Stages: 10, 15, 23, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 156
In situ reporter (knock in) 114
RT-PCR 42
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) Genomic(1) cDNA(62) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000025993 (Evidence)
Entrez Gene53945 (Evidence)
UniGene28756
DFCITC1575067, TC1595031, TC1608205
DoTSDT.101377678, DT.110898319, DT.532379
NIA Mouse Gene IndexU021297
Consensus CDS ProjectCCDS14933.1
International Mouse Knockout Project StatusSlc40a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53945 NCBI Gene Model | MGI Sequence Detail 17525 C57BL/6J ±  kb
transcript NM_016917 RefSeq | MGI Sequence Detail 3380 C57BL/6 
polypeptide Q9JHI9 UniProt | EBI | MGI Sequence Detail 570 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009716 Ferroporti-1
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000015138 solute carrier family 40 member 1
Graphical View of Protein Domain Structure
References (Earliest) J:30568 Cattanach BM, A new a mutation/ A dominant polycythaemia. Mouse Genome. 1995;93(4):1026-1029
(Latest) J:204136 Kautz L, et al., Testing the iron hypothesis in a mouse model of atherosclerosis. Cell Rep. 2013 Dec 12;5(5):1436-42
All references(74)
Disease annotation references (1)
Other
accession IDs
MGI:1860151, MGI:700182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory