Slc40a1^tm1.1Mmfe
Targeted Allele Detail

Summary

• Symbol: Slc40a1^tm1.1Mmfe
• Name: solute carrier family 40 (iron-regulated transporter), member 1; targeted mutation 1.1, Martina U Muckenthaler
• MGI ID: MGI:5607257
• Synonyms: Slc40a1^C326S
• Gene: Slc40a1 Location: Chr1:45947228-45965683 bp, - strand Genetic Position: Chr1, 23.96 cM, cytoband B
• Alliance: Slc40a1^tm1.1Mmfe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215585
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: The C326S point mutation was inserted in the seventh exon together with an intronic, floxed, promoterless Beta-Geo selection marker that was inserted into the sixth intron of the locus. The Beta-Geo cassette was removed via cre-mediated recombination. (J:215585)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc40a1 Mutation: 53 strains or lines available

References

• Original: J:215585 Altamura S, et al., Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload. Cell Metab. 2014 Aug 5;20(2):359-67
• All: 5 reference(s)