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M1ap Gene Detail
Summary
  • Symbol
    M1ap
  • Name
    meiosis 1 associated protein
  • Synonyms
    D6Mm5e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315200
    NCBI Gene: 110958
Location & Maps
more
  • Sequence Map
    Chr6:82946902-83030309 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      83408 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    M1AP, meiosis 1 associated protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    M1AP, meiosis 1 associated protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C2orf65, D6Mm5e, SPATA37
  • Links
    NCBI Gene ID: 130951
    neXtProt AC: NX_Q8TC57

  • Chr Location
    2p13.1; chr2:74557883-74648852 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 13210
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: M1AP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving M1ap
  • Incidental Mutations
    APF
Mice homozygous for a gene trap allele exhibit male infertility with oligospermia, globozooaspermiam decreased testies weight and size, degeneration of seminiferous tubules, male germ cell apoptosis and arrested male meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024060 VEGA Gene Model | MGI Sequence Detail 83408 C57BL/6J ±  kb
transcript OTTMUST00000058823 VEGA | MGI Sequence Detail 1945 Not Applicable  
polypeptide OTTMUSP00000028553 VEGA | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    382 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR033587 Meiosis 1 arrest protein
Molecular
Reagents
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  • All nucleic 18
    Genomic 9
    cDNA 9

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:50420 Weber JS, et al., High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6. Genomics. 1998 Nov 15;54(1):107-15
  • Latest
    J:194507 Arango NA, et al., Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (m1ap)-deficient mice. Biol Reprod. 2013;88(3):76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory