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Cldn4 Gene Detail
Summary
  • Symbol
    Cldn4
  • Name
    claudin 4
  • Synonyms
    Cpetr, Cpetr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313314
    NCBI Gene: 12740
  • Gene Overview
    MyGene.info: CLDN4
Location & Maps
more
  • Sequence Map
    Chr5:134945119-134946934 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1816 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.90 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CLDN4, claudin 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLDN4, claudin 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPER, CPE-R, CPETR, CPETR1, hCPE-R, WBSCR8
  • Links
    NCBI Gene ID: 1364
    neXtProt AC: NX_O14493

  • Chr Location
    7q11.23; chr7:73830863-73832693 (+)  GRCh38.p2

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Targeted
    7
  • Genomic Mutations
    2 involving Cldn4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit hydropherosis due to kidney pelvis and ureteral urothelium proliferation that leads to impaired calcium and chloride ion reabsorbtion and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055820 VEGA Gene Model | MGI Sequence Detail 1816 C57BL/6J ±  kb
transcript OTTMUST00000138146 VEGA | MGI Sequence Detail 1816 Not Applicable  
polypeptide OTTMUSP00000072665 VEGA | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    21 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 108
    Genomic 4
    cDNA 101
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGI:1202393
References
more
  • Summaries
    All 73
    Developmental Gene Expression 31
    Diseases 3
    Gene Ontology 10
    Phenotypes 9
  • Earliest
    J:43620 Katahira J, et al., Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J Biol Chem. 1997 Oct 17;272(42):26652-8
  • Latest
    J:224142 Reginensi A, et al., Yap and Taz are required for Ret-dependent urinary tract morphogenesis. Development. 2015 Aug 1;142(15):2696-703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory