Cldn4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cldn4
claudin 4
MGI:1313314

26 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cldn4^tm1.1Jhou/Cldn4^tm1.1Jhou Tg(Aqp2-cre)1Dek/0 B6.Cg-Cldn4^tm1.1Jhou Tg(Aqp2-cre)1Dek	abnormal renal reabsorption	J:216399
	abnormal renal sodium reabsorption	J:216399
	alkalosis	J:216399
	decreased body weight	J:216399
	decreased circulating chloride level	J:216399
	decreased mean systemic arterial blood pressure	J:216399
	increased circulating aldosterone level	J:216399
	increased circulating bicarbonate level	J:216399
	increased circulating potassium level	J:216399
	increased hematocrit	J:216399
	increased urine chloride ion level	J:216399
	increased urine sodium level	J:216399
	polyuria	J:216399
Cldn4^tm1.1Yham/Cldn4^tm1.1Yham B6.129S2-Cldn4^tm1.1Yham	abnormal kidney pelvis urothelium morphology	J:195766
	abnormal renal calcium reabsorption	J:195766
	abnormal renal reabsorption	J:195766
	abnormal renal/urinary system morphology	J:195766
	abnormal ureter physiology	J:195766
	decreased circulating calcium level	J:195766
	normal homeostasis/metabolism phenotype	J:195766
	hydronephrosis	J:195766
	increased kidney cell proliferation	J:195766
	increased urine calcium level	J:195766
	increased urine chloride ion level	J:195766
	premature death	J:195766
	normal renal/urinary system phenotype	J:195766
	ureter urothelium hyperplasia	J:195766
Cldn4^tm1.1Zboro/Cldn4^tm1.1Zboro involves: 129S4/SvJaeSor * 129S6/SvEvTac	no abnormal phenotype detected	J:216793

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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