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Vamp1
Gene Detail
Symbol

Name
ID
Vamp1
vesicle-associated membrane protein 1
MGI:1313276
Synonyms
lew, Syb1, Syb-1, VAMP-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:125215551-125244543 bp, + strand
From VEGA annotation of GRCm38

  28993 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40678  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: synaptobrevin
Gene Tree: Vamp1

Human
homologs
Human Homolog VAMP1, vesicle-associated membrane protein 1 (synaptobrevin 1)
NCBI Gene ID 6843
neXtProt AC  NX_P23763
Human Synonyms  SPAX1, SYB1, VAMP-1
Human Chr (Location)  12p; chr12:6462237-6470677 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human VAMP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(14) Spontaneous(1) Targeted(2)
 
Mice homozygous for a spontaneous mutation show a 30% reduction in body size, do not attempt to right themselves, become visibly immobile and lay on their side by postnatal day 10, and display a general lack of purposeful movement and wasting leading to death prior to weaning.
 
Interactions
Vamp1 interacts with 296 markers (Mir1a-2, Mir1b, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process exocytosis, neurotransmitter secretion, ...
Component cell junction, cell surface, ...
Function SNAP receptor activity, SNARE binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (7)    Tissues (4)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
Western blot 5
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000022687 (Evidence)
Ensembl Gene ModelENSMUSG00000030337 (Evidence)
Entrez Gene22317 (Evidence)
UniGene32321
DFCITC1576121, TC1588307, TC1596281
DoTSDT.101247968, DT.523178
Consensus CDS ProjectCCDS20546.1, CCDS39637.1
International Mouse Knockout Project StatusVamp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022687 VEGA Gene Model | MGI Sequence Detail 28993 C57BL/6J ±  kb
transcript OTTMUST00000088110 VEGA | MGI Sequence Detail 1400 Not Applicable 
polypeptide OTTMUSP00000048008 VEGA | MGI Sequence Detail 171 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001388 Synaptobrevin
InterPro IPR016444 Synaptobrevin, metazoa/fungi
Protein Ontology PR:000017248 vesicle-associated membrane protein 1
References
(Earliest) J:10766 Archer BT 3rd, et al., Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73
(Latest) J:185257 Liu Y, et al., The role of synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction. J Physiol. 2011 Apr 1;589(Pt 7):1603-18
All references(46)
Other
accession IDs
MGD-MRK-14675, MGD-MRK-14677, MGI:2449156, MGI:98458

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory