About   Help   FAQ
Vamp1 Gene Detail
Summary
  • Symbol
    Vamp1
  • Name
    vesicle-associated membrane protein 1
  • Synonyms
    lew, Syb1, Syb-1, VAMP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313276
    NCBI Gene: 22317
Location & Maps
more
  • Sequence Map
    Chr6:125215551-125244543 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28993 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    VAMP1, vesicle associated membrane protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VAMP1, vesicle associated membrane protein 1
    Orthology source: HomoloGene
  • Synonyms
    SPAX1, SYB1, VAMP-1
  • Links
    NCBI Gene ID: 6843
    neXtProt AC: NX_P23763

  • Chr Location
    12p; chr12:6462237-6470899 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human VAMP1 associations

Human Disease Mouse Models
       Spastic Ataxia 1, Autosomal Dominant; SPAX1   OMIM: 108600
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    14
  • Spontaneous
    1
  • Targeted
    2
Mice homozygous for a spontaneous mutation show a 30% reduction in body size, do not attempt to right themselves, become visibly immobile and lay on their side by postnatal day 10, and display a general lack of purposeful movement and wasting leading to death prior to weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022687 VEGA Gene Model | MGI Sequence Detail 28993 C57BL/6J ±  kb
transcript OTTMUST00000088110 VEGA | MGI Sequence Detail 1400 Not Applicable  
polypeptide OTTMUSP00000048008 VEGA | MGI Sequence Detail 171 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    127 from dbSNP Build 137
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR001388 Synaptobrevin
    IPR016444 Synaptobrevin/Vesicle-associated membrane protein
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-14675, MGD-MRK-14677, MGI:2449156, MGI:98458
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:10766 Archer BT 3rd, et al., Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73
  • Latest
    J:185257 Liu Y, et al., The role of synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction. J Physiol. 2011 Apr 1;589(Pt 7):1603-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory