Vamp1
Gene Detail

Symbol Name ID

Vamp1 vesicle-associated membrane protein 1 MGI:1313276

Synonyms

lew, Syb1, Syb-1, VAMP-1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

59.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:125215551-125244543 bp, + strand From VEGA annotation of GRCm38   28993 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40678  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: synaptobrevin
Gene Tree: Vamp1

Human homologs

Human Homolog		VAMP1, vesicle-associated membrane protein 1 (synaptobrevin 1)
NCBI Gene ID		6843
neXtProt AC		NX_P23763
Human Synonyms		SYB1, VAMP-1
Human Chr (Location)		12p; chr12:6571403-6579843 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(17) : Targeted(2) Gene trapped(14) Spontaneous(1)
 

Mice homozygous for a spontaneous mutation show a 30% reduction in body size, do not attempt to right themselves, become visibly immobile and lay on their side by postnatal day 10, and display a general lack of purposeful movement and wasting leading to death prior to weaning.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	vesicle-mediated transport
Component	cell junction, cytoplasmic vesicle, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (2)   
Theiler Stages: 26, 28

Assay Type	Results
Western blot	5

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000022687 (Evidence)
Ensembl Gene Model	ENSMUSG00000030337 (Evidence)
Entrez Gene	22317 (Evidence)
UniGene	32321
DFCI	TC1576121, TC1588307, TC1596281
DoTS	DT.101247968, DT.523178
Consensus CDS Project	CCDS20546.1, CCDS39637.1
International Mouse Knockout Project Status	Vamp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022687	VEGA Gene Model | MGI Sequence Detail	28993	C57BL/6J
transcript	OTTMUST00000088110	VEGA | MGI Sequence Detail	1400	Not Applicable
polypeptide	OTTMUSP00000048008	VEGA | MGI Sequence Detail	171	Not Applicable

All sequences(47) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001388	Synaptobrevin
InterPro	IPR016444	Synaptobrevin, metazoa/fungi
Protein Ontology	PR:000017248	vesicle-associated membrane protein 1

References

(Earliest) J:10766 Archer BT 3rd, et al., Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73
(Latest) J:185257 Liu Y, et al., The role of synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction. J Physiol. 2011 Apr 1;589(Pt 7):1603-18
All references(44)

Other accession IDs

MGD-MRK-14675, MGD-MRK-14677, MGI:2449156, MGI:98458