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Vamp1 Gene Detail
Summary
  • Symbol
    Vamp1
  • Name
    vesicle-associated membrane protein 1
  • Synonyms
    lew, Syb1, Syb-1, VAMP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313276
    NCBI Gene: 22317
  • Gene Overview
    MyGene.info: VAMP1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125215581-125222306 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313276
protein coding gene Chr6:125215551-125245964 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031291
protein coding gene Chr6:128556550-128586995 (+)
A/J MGP_AJ_G0031261
protein coding gene Chr6:123701448-123732029 (+)
AKR/J MGP_AKRJ_G0031189
protein coding gene Chr6:127081525-127111878 (+)
BALB/cJ MGP_BALBcJ_G0031269
protein coding gene Chr6:123298867-123329236 (+)
C3H/HeJ MGP_C3HHeJ_G0030992
protein coding gene Chr6:127150095-127180784 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031725
protein coding gene Chr6:131945647-131976025 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028874
protein coding gene Chr6:120911235-120918201 (+)
CAST/EiJ MGP_CASTEiJ_G0030373
protein coding gene Chr6:127357631-127389995 (+)
CBA/J MGP_CBAJ_G0030953
protein coding gene Chr6:136992179-137022954 (+)
DBA/2J MGP_DBA2J_G0031109
protein coding gene Chr6:122633255-122663821 (+)
FVB/NJ MGP_FVBNJ_G0031059
protein coding gene Chr6:121546270-121577075 (+)
LP/J MGP_LPJ_G0031189
protein coding gene Chr6:128714593-128747244 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031097
protein coding gene Chr6:141023530-141053998 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031760
protein coding gene Chr6:126983292-127013738 (+)
PWK/PhJ MGP_PWKPhJ_G0030088
protein coding gene Chr6:120877137-120907897 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029917
protein coding gene Chr6:125057892-125090153 (+)
WSB/EiJ MGP_WSBEiJ_G0030458
protein coding gene Chr6:127351340-127381757 (+)



Homology
more
  • Human Ortholog
    VAMP1, vesicle associated membrane protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VAMP1, vesicle associated membrane protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPAX1, SYB1, VAMP-1
  • Links
    NCBI Gene ID: 6843
    neXtProt AC: NX_P23763
    UniProt: P23763

  • Chr Location
    12p13.31; chr12:6462237-6470899 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human VAMP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation show a 30% reduction in body size, do not attempt to right themselves, become visibly immobile and lay on their side by postnatal day 10, and display a general lack of purposeful movement and wasting leading to death prior to weaning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22317 NCBI Gene Model | MGI Sequence Detail 6726 C57BL/6J ±  kb
    transcript NM_001080557 RefSeq | MGI Sequence Detail 3170 C57BL/6  
    polypeptide Q62442 UniProt | EBI | MGI Sequence Detail 118 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR036280 Multiheme cytochrome superfamily
      IPR001388 Synaptobrevin
      IPR016444 Synaptobrevin/Vesicle-associated membrane protein
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 38
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-14675, MGD-MRK-14677, MGI:2449156, MGI:98458
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:10766 Archer BT 3rd, et al., Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73
    • Latest
      J:263377 Zimmermann J, et al., Synaptobrevin 1 mediates vesicle priming and evoked release in a subpopulation of hippocampal neurons. J Neurophysiol. 2014 Sep 15;112(6):1559-65

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory