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Itm2b
Gene Detail
Symbol

Name
ID
Itm2b
integral membrane protein 2B
MGI:1309517
Synonyms
Bri2, Bricd2b, D14Sel6
Feature Type
protein coding gene
Genetic Map
Chromosome 14
38.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:73362231-73385271 bp, - strand
From NCBI annotation of GRCm38

  23041 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7388  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Itm2b

Human
homologs
Human Homolog ITM2B, integral membrane protein 2B
NCBI Gene ID 9445
neXtProt AC  NX_Q9Y287
Human Synonyms  ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, imBRI2
Human Chr (Location)  13q14.3; chr13:48233138-48262096 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ITM2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display increased levels of soluble APP fragments in the brain. Mice homozygous for a knock-in allele exhibit impaired oject recognition, impaired contextual conditioning, and impaired spatial working memory.
 
Human Diseases Modeled Using Mouse Itm2b (2)    Alleles Annotated to Human Diseases(3)   
Interactions
Itm2b interacts with 162 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (29)    Tissues (29)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(121)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(122) cDNA(122)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022108 (Evidence)
Entrez Gene16432 (Evidence)
DFCITC1573700, TC1617503
DoTSDT.40140561, DT.55277827, DT.91444347, DT.94302323, DT.97363029, DT.99871363
NIA Mouse Gene IndexU035764
Consensus CDS ProjectCCDS27269.1
International Mouse Knockout Project StatusItm2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16432 NCBI Gene Model | MGI Sequence Detail 23041 C57BL/6J ±  kb
transcript NM_008410 RefSeq | MGI Sequence Detail 1773 C57BL/6 
polypeptide O89051 UniProt | EBI | MGI Sequence Detail 266 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007084 BRICHOS domain
Protein Ontology PR:000032246 integral membrane protein 2B
Graphical View of Protein Domain Structure
References
(Earliest) J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
(Latest) J:198292 Lombino F, et al., An intracellular threonine of amyloid-beta precursor protein mediates synaptic plasticity deficits and memory loss. PLoS One. 2013;8(2):e57120
All references(49)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-25792, MGI:104443, MGI:2145608

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory