Cited2
Gene Detail

Symbol Name ID

Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 MGI:1306784

Synonyms

Mrg1, Msg2, p35srj

Feature Type

protein coding gene

Genetic Map

Chromosome 10

7.18 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:17723228-17725673 bp, + strand From Ensembl annotation of GRCm38   2446 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cited2

Human homologs

Human Homolog		CITED2, Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
NCBI Gene ID		10370
neXtProt AC		NX_Q99967
Human Synonyms		ASD8, MRG1, MRG-1, P35SRJ, VSD2
Human Chr (Location)		6q23.3; chr6:139693392-139695787 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CITED2

Alleles and phenotypes

All alleles(15) : Targeted(14) Gene trapped(1)
 

Mutations in this locus cause cardiac malformations, lethality between E13.5-18.5, neural tube defects, exencephaly, hydrops fetalis, small size, abnormal embryo turning, situs inversus, small spleen, dorsal root and cranial ganglia abnormalities, impaired kidney development and iris coloboma.

 
Human Diseases Modeled Using Mouse Cited2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (106 annotations)

Process	adrenal cortex formation, adrenal gland development, ...
Component	cytoplasm, nuclear chromatin, ...
Function	chromatin binding, histone acetyltransferase binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (34 records)
Data Summary: Results (225)    Tissues (205)    Images (47)
Theiler Stages: 2, 3, 4, 5, 8, 10, 11, 12, 13, 14, 16, 19, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	206
Northern blot	3
RT-PCR	15

cDNA source data(125)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(128) cDNA(125) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000039910 (Evidence)
Entrez Gene	17684 (Evidence)
UniGene	272321
DFCI	TC1575381, TC1595386
DoTS	DT.494096
NIA Mouse Gene Index	U011296
Consensus CDS Project	CCDS23708.1
International Mouse Knockout Project Status	Cited2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000039910	Ensembl Gene Model | MGI Sequence Detail	2446	C57BL/6J
transcript	ENSMUST00000038107	Ensembl | MGI Sequence Detail	1968	Not Applicable
polypeptide	ENSMUSP00000038405	Ensembl | MGI Sequence Detail	269	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007576	CITED
Protein Ontology	PR:000005506	Cbp/p300-interacting transactivator 2

References

(Earliest) J:48778 Shioda T, et al., MSG1 and its related protein MRG1 share a transcription activating domain. Gene. 1997 Dec 19;204(1-2):235-41
(Latest) J:192202 Chen CM, et al., Functional significance of SRJ domain mutations in CITED2. PLoS One. 2012;7(10):e46256
All references(87)

Other accession IDs

MGI:2143671