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Cited2 Gene Detail
Summary
  • Symbol
    Cited2
  • Name
    Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
  • Synonyms
    Mrg1, Msg2, p35srj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306784
    NCBI Gene: 17684
  • Gene Overview
    MyGene.info: CITED2
Location & Maps
more
  • Sequence Map
    Chr10:17723228-17725673 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2446 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 7.18 cM, cytoband A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CITED2, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CITED2, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASD8, MRG1, MRG-1, P35SRJ, VSD2
  • Links
    NCBI Gene ID: 10370
    neXtProt AC: NX_Q99967

  • Chr Location
    6q24.1; chr6:139372255-139374650 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cited2 mouse models; 2 with human CITED2 associations

Human Disease Mouse Models
       Tetralogy of Fallot; TOF   OMIM: 187500 View 1 model
       Atrial Septal Defect 8; ASD8   OMIM: 614433
Ventricular Septal Defect 2; VSD2   OMIM: 614431
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    89 phenotypes from 12 alleles in 15 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Targeted
    14
  • Incidental Mutations
Mutations in this locus cause cardiac malformations, lethality between E13.5-18.5, neural tube defects, exencephaly, hydrops fetalis, small size, abnormal embryo turning, situs inversus, small spleen, dorsal root and cranial ganglia abnormalities, impaired kidney development and iris coloboma.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039910 Ensembl Gene Model | MGI Sequence Detail 2446 C57BL/6J ±  kb
transcript ENSMUST00000038107 Ensembl | MGI Sequence Detail 1968 Not Applicable  
polypeptide ENSMUSP00000038405 Ensembl | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 128
    cDNA 123
    Primer pair 3
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143671
References
more
  • Summaries
    All 93
    Developmental Gene Expression 38
    Diseases 1
    Gene Ontology 21
    Phenotypes 40
  • Earliest
    J:48778 Shioda T, et al., MSG1 and its related protein MRG1 share a transcription activating domain. Gene. 1997 Dec 19;204(1-2):235-41
  • Latest
    J:234341 Fame RM, et al., Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity. J Neurosci. 2016 Jun 15;36(24):6403-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory