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Cited2
Gene Detail
 Symbol
Name
ID
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
MGI:1306784
Synonyms Mrg1, Msg2, p35srj
Feature Type protein coding gene
Genetic Map
Chromosome 10
7.18 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:17723228-17725673 bp, + strand
From Ensembl annotation of GRCm38

  2446 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cited2

Human
homologs
Human Homolog CITED2, Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
NCBI Gene ID 10370
neXtProt AC  NX_Q99967
Human Synonyms  ASD8, MRG1, MRG-1, P35SRJ, VSD2
Human Chr (Location)  6q23.3; chr6:139372255-139374650 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CITED2
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(1) Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this locus cause cardiac malformations, lethality between E13.5-18.5, neural tube defects, exencephaly, hydrops fetalis, small size, abnormal embryo turning, situs inversus, small spleen, dorsal root and cranial ganglia abnormalities, impaired kidney development and iris coloboma.
 
Human Diseases Modeled Using Mouse Cited2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(6)
Interactions
Cited2 interacts with 238 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (108 annotations)
Process adrenal cortex formation, adrenal gland development, ...
Component cytoplasm, nuclear chromatin, ...
Function chromatin binding, histone acetyltransferase binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (232)    Tissues (207)    Images (56)
Theiler Stages: 2, 3, 4, 5, 8, 10, 11, 12, 13, 14, 15, 16, 17, 19, 21, 22, 23, 26, 27, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 211
In situ reporter (knock in) 4
Northern blot 3
RT-PCR 13
cDNA source data(123)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(128) cDNA(123) Primer pair(3) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000039910 (Evidence)
Entrez Gene17684 (Evidence)
UniGene272321
DFCITC1575381, TC1595386
DoTSDT.494096
NIA Mouse Gene IndexU011296
Consensus CDS ProjectCCDS23708.1
International Mouse Knockout Project StatusCited2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039910 Ensembl Gene Model | MGI Sequence Detail 2446 C57BL/6J ±  kb
transcript ENSMUST00000038107 Ensembl | MGI Sequence Detail 1968 Not Applicable 
polypeptide ENSMUSP00000038405 Ensembl | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007576 CITED
Protein Ontology PR:000005506 Cbp/p300-interacting transactivator 2
References (Earliest) J:48778 Shioda T, et al., MSG1 and its related protein MRG1 share a transcription activating domain. Gene. 1997 Dec 19;204(1-2):235-41
(Latest) J:203711 Wainwright EN, et al., SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation. Biol Reprod. 2013 Aug;89(2):34
All references(89)
Disease annotation references (1)
Other
accession IDs
MGI:2143671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory