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Dio3 Gene Detail
Summary
  • Symbol
    Dio3
  • Name
    deiodinase, iodothyronine type III
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306782
    NCBI Gene: 107585
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:110279068-110281097 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2030 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 60.56 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DIO3, iodothyronine deiodinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DIO3, iodothyronine deiodinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5DIII, D3, DIOIII, TXDI3
  • Links
    NCBI Gene ID: 1735
    neXtProt AC: NX_P55073
    UniProt: P55073

  • Chr Location
    14q32.31; chr14:101561351-101563452 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show partial embryonic or perinatal mortality, growth retardation, reduced fertility, and severe anomalies in thyroid status and physiology, including reduced T3 clearance and neonatal thyrotoxicosis followed by central hypothyroidism that persists throughout life.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000038181 VEGA Gene Model | MGI Sequence Detail 2030 C57BL/6J ±  kb
    transcript OTTMUST00000098316 VEGA | MGI Sequence Detail 2030 Not Applicable  
    polypeptide OTTMUSP00000055226 VEGA | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      13 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 3
      cDNA 9
      Primer pair 5
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 29
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:50456 Hernandez A, et al., Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1. Genomics. 1998 Oct 1;53(1):119-21
    • Latest
      J:255598 van der Spek AH, et al., The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species. Endocrinology. 2018 Feb 1;159(2):826-835

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory