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Dio3 Gene Detail
Summary
  • Symbol
    Dio3
  • Name
    deiodinase, iodothyronine type III
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306782
    NCBI Gene: 107585
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:110279230-110281097 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 60.56 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306782
protein coding gene Chr12:110279068-110281097 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020116
protein coding gene Chr12:112560353-112562382 (+)
A/J MGP_AJ_G0020070
protein coding gene Chr12:108206440-108208469 (+)
AKR/J MGP_AKRJ_G0020046
protein coding gene Chr12:111374765-111376793 (+)
BALB/cJ MGP_BALBcJ_G0020056
protein coding gene Chr12:108683646-108685675 (+)
C3H/HeJ MGP_C3HHeJ_G0019858
protein coding gene Chr12:111819610-111821639 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020501
protein coding gene Chr12:116001616-116003645 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018113
protein coding gene Chr12:104710790-104712821 (+)
CAST/EiJ MGP_CASTEiJ_G0019400
protein coding gene Chr12:106771962-106773991 (+)
CBA/J MGP_CBAJ_G0019825
protein coding gene Chr12:120511813-120513842 (+)
DBA/2J MGP_DBA2J_G0019942
protein coding gene Chr12:107752375-107754403 (+)
FVB/NJ MGP_FVBNJ_G0019927
protein coding gene Chr12:106553736-106555765 (+)
LP/J MGP_LPJ_G0020017
protein coding gene Chr12:112394732-112396761 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019965
protein coding gene Chr12:123667136-123669164 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020530
protein coding gene Chr12:110851274-110853303 (+)
PWK/PhJ MGP_PWKPhJ_G0019159
protein coding gene Chr12:102367046-102369075 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018963
protein coding gene Chr12:105018042-105020072 (+)
WSB/EiJ MGP_WSBEiJ_G0019457
protein coding gene Chr12:111764960-111766989 (+)



Homology
more
  • Human Ortholog
    DIO3, iodothyronine deiodinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DIO3, iodothyronine deiodinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5DIII, D3, DIOIII, TXDI3
  • Links
    NCBI Gene ID: 1735
    neXtProt AC: NX_P55073
    UniProt: P55073

  • Chr Location
    14q32.31; chr14:101561351-101563452 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show partial embryonic or perinatal mortality, growth retardation, reduced fertility, and severe anomalies in thyroid status and physiology, including reduced T3 clearance and neonatal thyrotoxicosis followed by central hypothyroidism that persists throughout life.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107585 NCBI Gene Model | MGI Sequence Detail 1868 C57BL/6J ±  kb
    transcript NM_172119 RefSeq | MGI Sequence Detail 1872 C57BL/6  
    polypeptide Q91ZI8 UniProt | EBI | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 10
      Primer pair 5
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 29
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:50456 Hernandez A, et al., Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1. Genomics. 1998 Oct 1;53(1):119-21
    • Latest
      J:255598 van der Spek AH, et al., The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species. Endocrinology. 2018 Feb 1;159(2):826-835

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory