Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables thyroxine 5'-deiodinase activity and thyroxine 5-deiodinase activity. Involved in thyroid hormone catabolic process. Acts upstream of or within regulation of growth and retinal cone cell apoptotic process. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; sensory organ; and tongue. Orthologous to human DIO3 (iodothyronine deiodinase 3).