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Sucla2
Gene Detail
 Symbol
Name
ID
Sucla2
succinate-Coenzyme A ligase, ADP-forming, beta subunit
MGI:1306775
Synonyms 4930547K18Rik
Feature Type protein coding gene
Genetic Map
Chromosome 14
39.06 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:73525319-73596142 bp, + strand
From VEGA annotation of GRCm38

  70824 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: succinyl-CoA synthetase, beta subunit
Gene Tree: Sucla2

Human
homologs
Human Homolog SUCLA2, succinate-CoA ligase, ADP-forming, beta subunit
NCBI Gene ID 8803
neXtProt AC  NX_Q9P2R7
Human Synonyms  A-BETA, MTDPS5, SCS-betaA
Human Chr (Location)  13q12.2-q13.3; chr13:47942656-48001326 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SUCLA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Sucla2 interacts with 161 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process metabolic process, succinate metabolic process, ...
Component extracellular vesicular exosome, mitochondrion
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (161)    Tissues (105)    Images (36)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 161
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035022 (Evidence)
Ensembl Gene ModelENSMUSG00000022110 (Evidence)
Entrez Gene20916 (Evidence)
DFCITC1572007, TC1643506
DoTSDT.495140, DT.55271312, DT.99863666
NIA Mouse Gene IndexU159572
EC6.2.1.5
Consensus CDS ProjectCCDS27271.1
International Mouse Knockout Project StatusSucla2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035022 VEGA Gene Model | MGI Sequence Detail 70824 C57BL/6J ±  kb
transcript OTTMUST00000089057 VEGA | MGI Sequence Detail 2229 Not Applicable 
polypeptide OTTMUSP00000048616 VEGA | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(5)
Polymorphisms SNPs within 2kb(827 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005811 ATP-citrate lyase/succinyl-CoA ligase
InterPro IPR011761 ATP-grasp fold
InterPro IPR013815 ATP-grasp fold, subdomain 1
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
InterPro IPR005809 Succinyl-CoA synthetase, beta subunit
InterPro IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
InterPro IPR016102 Succinyl-CoA synthetase-like
Protein Ontology PR:000015811 succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
References (Earliest) J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)
Other
accession IDs
MGI:1922515

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory