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Sucla2
Gene Detail
Symbol

Name
ID
Sucla2
succinate-Coenzyme A ligase, ADP-forming, beta subunit
MGI:1306775
Synonyms
4930547K18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 14
39.06 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:73525319-73596142 bp, + strand
From VEGA annotation of GRCm38

  70824 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: succinyl-CoA synthetase, beta subunit
Gene Tree: Sucla2

Human
homologs
Human Homolog SUCLA2, succinate-CoA ligase, ADP-forming, beta subunit
NCBI Gene ID 8803
neXtProt AC  NX_Q9P2R7
Human Synonyms  A-BETA, MTDPS5, SCS-betaA
Human Chr (Location)  13q12.2-q13.3; chr13:47942656-48001326 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SUCLA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit perinatal lethality with reduced size, placenta mineralization, decreased mitochondrial DNA and respiration.
 
Human Diseases Modeled Using Mouse Sucla2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sucla2 interacts with 161 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process metabolic process, succinate metabolic process, ...
Component extracellular vesicular exosome, mitochondrion, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (161)    Tissues (105)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 161
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035022 (Evidence)
Ensembl Gene ModelENSMUSG00000022110 (Evidence)
Entrez Gene20916 (Evidence)
DFCITC1643506, TC1572007
DoTSDT.99863666, DT.55271312, DT.495140
NIA Mouse Gene IndexU159572
EC6.2.1.5
Consensus CDS ProjectCCDS27271.1
International Mouse Knockout Project StatusSucla2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035022 VEGA Gene Model | MGI Sequence Detail 70824 C57BL/6J ±  kb
transcript OTTMUST00000089057 VEGA | MGI Sequence Detail 2229 Not Applicable 
polypeptide OTTMUSP00000048616 VEGA | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(6) UniProt(9)
Polymorphisms
SNPs within 2kb(827 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005811 ATP-citrate lyase/succinyl-CoA ligase
InterPro IPR011761 ATP-grasp fold
InterPro IPR013815 ATP-grasp fold, subdomain 1
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
InterPro IPR005809 Succinyl-CoA synthetase, beta subunit
InterPro IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
InterPro IPR016102 Succinyl-CoA synthetase-like
Protein Ontology PR:000015811 succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
References
(Earliest) J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
(Latest) J:213453 Donti TR, et al., Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion. Dis Model Mech. 2014 Feb;7(2):271-80
All references(42)
Disease annotation references (1)
Other
accession IDs
MGI:1922515

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory