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Sucla2 Gene Detail
Summary
  • Symbol
    Sucla2
  • Name
    succinate-Coenzyme A ligase, ADP-forming, beta subunit
  • Synonyms
    4930547K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306775
    NCBI Gene: 20916
Location & Maps
more
  • Sequence Map
    Chr14:73525319-73596142 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70824 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SUCLA2, succinate-CoA ligase, ADP-forming, beta subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SUCLA2, succinate-CoA ligase, ADP-forming, beta subunit
    Orthology source: HomoloGene
  • Synonyms
    A-BETA, MTDPS5, SCS-betaA
  • Links
    NCBI Gene ID: 8803
    neXtProt AC: NX_Q9P2R7

  • Chr Location
    13q14.2; chr13:47942656-48001326 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Sucla2 mouse models; 1 with human SUCLA2 associations

Human Disease Mouse Models
       Mitochondrial DNA Depletion Syndrome 5 (encephalomyopathic with or without Methylmalonic Aciduria); MTDPS5   OMIM: 612073 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    5
  • Genomic Mutations
    1 involving Sucla2
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit perinatal lethality with reduced size, placenta mineralization, decreased mitochondrial DNA and respiration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035022 VEGA Gene Model | MGI Sequence Detail 70824 C57BL/6J ±  kb
transcript OTTMUST00000089075 VEGA | MGI Sequence Detail 1545 Not Applicable  
polypeptide OTTMUSP00000048627 VEGA | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    827 from dbSNP Build 137
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015811 succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
  • EC
  • InterPro Domains
    IPR005811 ATP-citrate lyase/succinyl-CoA ligase
    IPR011761 ATP-grasp fold
    IPR013815 ATP-grasp fold, subdomain 1
    IPR013816 ATP-grasp fold, subdomain 2
    IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
    IPR005809 Succinyl-CoA synthetase, beta subunit
    IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
    IPR016102 Succinyl-CoA synthetase-like
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1922515
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
  • Latest
    J:213453 Donti TR, et al., Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion. Dis Model Mech. 2014 Feb;7(2):271-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory