Sucla2
Gene Detail

Symbol Name ID

Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit MGI:1306775

Synonyms

4930547K18Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 14

39.06 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:73525319-73596142 bp, + strand From VEGA annotation of GRCm38   70824 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: succinyl-CoA synthetase, beta subunit
Gene Tree: Sucla2

Human homologs

Human Homolog		SUCLA2, succinate-CoA ligase, ADP-forming, beta subunit
NCBI Gene ID		8803
neXtProt AC		NX_Q9P2R7
Human Synonyms		A-BETA, MTDPS5, SCS-betaA
Human Chr (Location)		13q12.2-q13.3; chr13:48516791-48575462 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SUCLA2

Alleles and phenotypes

All alleles(11) : Targeted(5) Gene trapped(6)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	metabolic process, succinate metabolic process, ...
Component	mitochondrion
Function	ATP binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (161)    Tissues (105)    Images (36)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	161

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000035022 (Evidence)
Ensembl Gene Model	ENSMUSG00000022110 (Evidence)
Entrez Gene	20916 (Evidence)
DFCI	TC1572007, TC1643506
DoTS	DT.495140, DT.55271312, DT.99863666
NIA Mouse Gene Index	U159572
EC	6.2.1.5
Consensus CDS Project	CCDS27271.1
International Mouse Knockout Project Status	Sucla2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035022	VEGA Gene Model | MGI Sequence Detail	70824	C57BL/6J
transcript	OTTMUST00000089075	VEGA | MGI Sequence Detail	1545	Not Applicable
polypeptide	OTTMUSP00000048627	VEGA | MGI Sequence Detail	463	Not Applicable

All sequences(57) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(325 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005811	ATP-citrate lyase/succinyl-CoA ligase
InterPro	IPR011761	ATP-grasp fold
InterPro	IPR013815	ATP-grasp fold, subdomain 1
InterPro	IPR013816	ATP-grasp fold, subdomain 2
InterPro	IPR013650	ATP-grasp fold, succinyl-CoA synthetase-type
InterPro	IPR005809	Succinyl-CoA synthetase, beta subunit
InterPro	IPR017866	Succinyl-CoA synthetase, beta subunit, conserved site
InterPro	IPR016102	Succinyl-CoA synthetase-like
Protein Ontology	PR:000015811	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
Protein Ontology	PR:000027779	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (mouse)

References

(Earliest) J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)

Other accession IDs

MGI:1922515