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Mpzl2
Gene Detail
Symbol

Name
ID
Mpzl2
myelin protein zero-like 2
MGI:1289160
Synonyms
Eva, Eva1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:45042425-45054015 bp, + strand
From VEGA annotation of GRCm38

  11591 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7309  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MPZL2
Gene Tree: Mpzl2

Human
homologs
MPZL2, myelin protein zero-like 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10205
neXtProt AC: NX_O60487

Human Synonyms: EVA, EVA1

Human Chr (Location): 11q24; chr11:118253416-118264536 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit alterations in immune cell percentages in peripheral blood and in spleen.
 
Interactions
Mpzl2 interacts with 238 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell adhesion, single organismal cell-cell adhesion, ...
Component integral component of membrane, membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (72)    Tissues (66)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
Northern blot 2
RT-PCR 16
RNase protection 9
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mpzl2 ; ZFIN mpzl2b    NEW 
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016711 (Evidence)
Ensembl Gene Model ENSMUSG00000032092 (Evidence)
Entrez Gene 14012 (Evidence)
UniGene 33240
DFCI TC1575926, TC1683555
DoTS DT.91397995, DT.486943, DT.101385390
Consensus CDS Project CCDS23126.1
International Mouse Phenotyping Consortium Status Mpzl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016711 VEGA Gene Model | MGI Sequence Detail 11591 C57BL/6J ±  kb
transcript OTTMUST00000040499 VEGA | MGI Sequence Detail 3107 Not Applicable 
polypeptide OTTMUSP00000018103 VEGA | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR000920 Myelin P0 protein
Protein Ontology PR:000010555 myelin protein zero-like protein 2
References
(Earliest) J:48229 Guttinger M, et al., Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis. J Cell Biol. 1998 May 18;141(4):1061-71
(Latest) J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory