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Mpzl2
Gene Detail
Symbol

Name
ID
Mpzl2
myelin protein zero-like 2
MGI:1289160
Synonyms
Eva, Eva1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:45042425-45054015 bp, + strand
From VEGA annotation of GRCm38

  11591 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7309  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mpzl2

Human
homologs
Human Homolog MPZL2, myelin protein zero-like 2
NCBI Gene ID 10205
neXtProt AC  NX_O60487
Human Synonyms  EVA, EVA1
Human Chr (Location)  11q24; chr11:118253416-118264536 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit alterations in immune cell percentages in peripheral blood and in spleen.
 
Interactions
Mpzl2 interacts with 238 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell adhesion, single organismal cell-cell adhesion, ...
Component integral component of membrane, membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (74)    Tissues (68)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 47
Northern blot 2
RT-PCR 16
RNase protection 9
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016711 (Evidence)
Ensembl Gene ModelENSMUSG00000032092 (Evidence)
Entrez Gene14012 (Evidence)
UniGene33240
DFCITC1683555, TC1575926
DoTSDT.486943, DT.91397995, DT.101385390
Consensus CDS ProjectCCDS23126.1
International Mouse Knockout Project StatusMpzl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016711 VEGA Gene Model | MGI Sequence Detail 11591 C57BL/6J ±  kb
transcript OTTMUST00000040499 VEGA | MGI Sequence Detail 3107 Not Applicable 
polypeptide OTTMUSP00000018103 VEGA | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
InterPro IPR000920 Myelin P0 protein
Protein Ontology PR:000010555 myelin protein zero-like protein 2
References
(Earliest) J:48229 Guttinger M, et al., Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis. J Cell Biol. 1998 May 18;141(4):1061-71
(Latest) J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory