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Lect2
Gene Detail
Symbol

Name
ID
Lect2
leukocyte cell-derived chemotaxin 2
MGI:1278342
Synonyms
chondromodulin-II
Feature Type
protein coding gene
Genetic Map
Chromosome 13
30.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:56542460-56548538 bp, - strand
From Ensembl annotation of GRCm38

  6079 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

HCOP human homology predictions: LECT2
Protein SuperFamily: leukocyte cell-derived chemotaxin 2
Gene Tree: Lect2

Human
homologs
LECT2, leukocyte cell-derived chemotaxin 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3950
neXtProt AC: NX_O14960

Human Synonyms: chm2, chm-II

Human Chr (Location): 5q31.1; chr5:135946911-135955034 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from CvDC )
 
Homozygous null mice display increased hepatic NKT cell numbers, increased induced cytokine secretion, and increased sensitivity to induced hepatitis.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Lect2 interacts with 26 markers (Mir32, Mir135a-1, Mir135a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process chemotaxis, negative regulation of Wnt signaling pathway
Component extracellular region
Function identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (36)    Tissues (3)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(3) cDNA(6) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000021539 (Evidence)
Entrez Gene 16841 (Evidence)
DFCI TC1710861, TC1596428, TC1586369
DoTS DT.60103886, DT.531263, DT.87049777
NIA Mouse Gene Index U034834
Consensus CDS Project CCDS26564.1
International Mouse Phenotyping Consortium Status Lect2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021539 Ensembl Gene Model | MGI Sequence Detail 6079 C57BL/6J ±  kb
transcript ENSMUST00000062806 Ensembl | MGI Sequence Detail 877 Not Applicable 
polypeptide ENSMUSP00000060495 Ensembl | MGI Sequence Detail 151 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008663 Leukocyte cell-derived chemotaxin 2
InterPro IPR017381 Leukocyte cell-derived chemotaxin 2, chordata
InterPro IPR016047 Peptidase M23
Protein Ontology PR:000009750 leukocyte cell-derived chemotaxin-2
References
(Earliest) J:49542 Yamagoe S, et al., The mouse Lect2 gene: cloning of cDNA and genomic DNA, structural characterization and chromosomal localization. Gene. 1998 Aug 17;216(1):171-8
(Latest) J:201286 Okumura A, et al., Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein. FEBS Lett. 2013 Mar 1;587(5):404-9
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory