About   Help   FAQ
Lect2
Gene Detail
 Symbol
Name
ID
Lect2
leukocyte cell-derived chemotaxin 2
MGI:1278342
Synonyms chondromodulin-II
Feature Type protein coding gene
Genetic Map
Chromosome 13
30.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:56542460-56548538 bp, - strand
From NCBI annotation of GRCm38

  6079 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: leukocyte cell-derived chemotaxin 2
Gene Tree: Lect2

Human
homologs
Human Homolog LECT2, leukocyte cell-derived chemotaxin 2
NCBI Gene ID 3950
neXtProt AC  NX_O14960
Human Synonyms  chm2, chm-II
Human Chr (Location)  5q31.1; chr5:135946911-135955034 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous null mice display increased hepatic NKT cell numbers, increased induced cytokine secretion, and increased sensitivity to induced hepatitis.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Lect2 interacts with 26 markers (Mir32, Mir135a-1, Mir135a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process chemotaxis, negative regulation of Wnt signaling pathway
Component extracellular region
Function identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (36)    Tissues (3)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 36
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(3) cDNA(6) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000021539 (Evidence)
Entrez Gene16841 (Evidence)
DFCITC1586369, TC1596428, TC1710861
DoTSDT.531263, DT.60103886, DT.87049777
NIA Mouse Gene IndexU034834
Consensus CDS ProjectCCDS26564.1
International Mouse Knockout Project StatusLect2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16841 NCBI Gene Model | MGI Sequence Detail 6079 C57BL/6J ±  kb
transcript NM_010702 RefSeq | MGI Sequence Detail 889 C57BL/6 
polypeptide O88803 UniProt | EBI | MGI Sequence Detail 151 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008663 Leukocyte cell-derived chemotaxin 2
InterPro IPR017381 Leukocyte cell-derived chemotaxin 2, chordata
InterPro IPR016047 Peptidase M23
Protein Ontology PR:000009750 leukocyte cell-derived chemotaxin-2
Graphical View of Protein Domain Structure
References (Earliest) J:49542 Yamagoe S, et al., The mouse Lect2 gene: cloning of cDNA and genomic DNA, structural characterization and chromosomal localization. Gene. 1998 Aug 17;216(1):171-8
(Latest) J:201286 Okumura A, et al., Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein. FEBS Lett. 2013 Mar 1;587(5):404-9
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory