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Lect2 Gene Detail
Summary
  • Symbol
    Lect2
  • Name
    leukocyte cell-derived chemotaxin 2
  • Synonyms
    chondromodulin-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278342
    NCBI Gene: 16841
Location & Maps
more
  • Sequence Map
    Chr13:56542460-56548538 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6079 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LECT2, leukocyte cell derived chemotaxin 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LECT2, leukocyte cell derived chemotaxin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    chm2, chm-II
  • Links
    NCBI Gene ID: 3950
    neXtProt AC: NX_O14960

  • Chr Location
    5q31.1; chr5:135946911-135955034 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Lect2
  • Incidental Mutations
Homozygous null mice display increased hepatic NKT cell numbers, increased induced cytokine secretion, and increased sensitivity to induced hepatitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021539 Ensembl Gene Model | MGI Sequence Detail 6079 C57BL/6J ±  kb
transcript ENSMUST00000062806 Ensembl | MGI Sequence Detail 877 Not Applicable  
polypeptide ENSMUSP00000060495 Ensembl | MGI Sequence Detail 151 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    88 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR008663 Leukocyte cell-derived chemotaxin 2
    IPR017381 Leukocyte cell-derived chemotaxin 2, chordata
    IPR016047 Peptidase M23
Molecular
Reagents
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  • All nucleic 10
    Genomic 3
    cDNA 6
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:49542 Yamagoe S, et al., The mouse Lect2 gene: cloning of cDNA and genomic DNA, structural characterization and chromosomal localization. Gene. 1998 Aug 17;216(1):171-8
  • Latest
    J:201286 Okumura A, et al., Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein. FEBS Lett. 2013 Mar 1;587(5):404-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory