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Cdkl5
Gene Detail
 Symbol
Name
ID
Cdkl5
cyclin-dependent kinase-like 5
MGI:1278336
Synonyms Stk9
Feature Type protein coding gene
Genetic Map
Chromosome X
73.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:160784308-160994702 bp, - strand
From VEGA annotation of GRCm38

  210395 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cdkl5

Human
homologs
Human Homolog CDKL5, cyclin-dependent kinase-like 5
NCBI Gene ID 6792
neXtProt AC  NX_O76039
Human Synonyms  EIEE2, ISSX, STK9
Human Chr (Location)  Xp22; chrX:18425605-18653629 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CDKL5
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(10) Spontaneous(1) Targeted(5)
Genomic Mutations involving Cdkl5 (1)
Incidental mutations (data from APF )
 
Male mice hemizygous for a knock-out allele exhibit hyperactivity, impaired coordination, decreased anxiety-related response, limb grasping, social withdrawal, and impaired nesting, conditioned behavior learning and auditory-evoked event-related potentials.
 
Human Diseases Modeled Using Mouse Cdkl5 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Cdkl5 interacts with 58 markers (Mir10b, Mir23b, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process neuron migration, phosphorylation, ...
Component cytoplasm, dendrite cytoplasm, ...
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (13)    Tissues (13)   
Theiler Stages: 11, 15, 17, 20, 25, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 3
Northern blot 8
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000019591 (Evidence)
Ensembl Gene ModelENSMUSG00000031292 (Evidence)
Entrez Gene382253 (Evidence)
UniGene443717
DFCITC1612152, TC1614988, TC1639357, TC1770882
DoTSDT.55254770, DT.87059363, DT.91297660
NIA Mouse Gene IndexU039834
EC2.7.11.22
Consensus CDS ProjectCCDS53238.1
International Mouse Knockout Project StatusCdkl5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019591 VEGA Gene Model | MGI Sequence Detail 210395 C57BL/6J ±  kb
transcript OTTMUST00000046802 VEGA | MGI Sequence Detail 3267 Not Applicable 
polypeptide OTTMUSP00000021165 VEGA | MGI Sequence Detail 938 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(547 from dbSNP Build 137)    SNPs within 2kb including multiple locations(549)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005273 cyclin-dependent kinase-like 5
References (Earliest) J:49736 Montini E, et al., Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region. Genomics. 1998 Aug 1;51(3):427-33
(Latest) J:209635 Amendola E, et al., Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder. PLoS One. 2014;9(5):e91613
All references(37)
Disease annotation references (1)
Other
accession IDs
MGI:2448589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory