Symbol
Name
ID

Cdkl5
cyclin dependent kinase like 5
MGI:1278336

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Drooling	Feeding difficulties	Inappropriate crying	Reduced social reciprocity	Autistic behavior	Motor stereotypy	Bruxism	Tongue thrusting	Stereotypical hand wringing
Disease(s) Associated with CDKL5	Drooling	Feeding difficulties	Inappropriate crying	Reduced social reciprocity	Autistic behavior	Motor stereotypy	Bruxism	Tongue thrusting	Stereotypical hand wringing
developmental and epileptic encephalopathy 2
Rett syndrome

Mouse Phenotypes

behavior/neurological phenotype

abnormal behavior

impaired contextual conditioning behavior

impaired cued conditioning behavior

decreased anxiety-related response

limb grasping

impaired coordination

decreased locomotor activity

hyperactivity

abnormal nest building behavior

social withdrawal

seizures

abnormal seizure response to inducing agent

Availability

Mouse Genotype

Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr

Cdkl5^tm1.2Cogr/Cdkl5⁺

Cdkl5^tm1.1Joez/Y

Cdkl5^tm1.2Cogr/Y

Cdkl5^tm1.3Cogr/?

Cdkl5^tm1.1Cogr/Cdkl5⁺
Tg(Emx1-cre)#Ito/0 (conditional)

Cdkl5^tm1.1Cogr/Y
Tg(dlx5a-cre)1Mekk/0 (conditional)

Cdkl5^tm1.1Cogr/Y
Tg(Emx1-cre)#Ito/0 (conditional)

Cdkl5^tm1.1Cogr/?
Tg(dlx5a-cre)1Mekk/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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