Cdkl5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdkl5
cyclin dependent kinase like 5
MGI:1278336

23 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkl5^tm1.1Cogr/Cdkl5⁺ Tg(Emx1-cre)#Ito/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J	normal behavior/neurological phenotype	J:209635
	limb grasping	J:209635
Cdkl5^tm1.1Cogr/Y Tg(dlx5a-cre)1Mekk/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1	normal behavior/neurological phenotype	J:209635
Cdkl5^tm1.1Cogr/? Tg(dlx5a-cre)1Mekk/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * CD-1	normal behavior/neurological phenotype	J:209635
	decreased locomotor activity	J:209635
Cdkl5^tm1.1Cogr/Y Tg(Emx1-cre)#Ito/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J	normal behavior/neurological phenotype	J:209635
	limb grasping	J:209635
Cdkl5^tm1.1Joez/Y B6.129(FVB)-Cdkl5^tm1.1Joez	abnormal nervous system electrophysiology	J:193172
	abnormal nest building behavior	J:193172
	decreased anxiety-related response	J:193172
	hyperactivity	J:193172
	impaired contextual conditioning behavior	J:193172
	impaired coordination	J:193172
	impaired cued conditioning behavior	J:193172
	limb grasping	J:193172
	normal nervous system phenotype	J:193172
	social withdrawal	J:193172
	normal taste/olfaction phenotype	J:193172
Cdkl5^tm1.2Cogr/Cdkl5⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	abnormal visual evoked potential	J:209635
	decreased locomotor activity	J:209635
	limb grasping	J:209635
Cdkl5^tm1.2Cogr/Y involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	abnormal seizure response to inducing agent	J:209635
	abnormal visual evoked potential	J:209635
	decreased locomotor activity	J:209635
	limb grasping	J:209635
	seizures	J:209635
Cdkl5^tm1.2Cogr/Cdkl5⁺ Tg(Thy1-YFP)#Jrs/0 involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA	abnormal dendrite morphology	J:209635
	thin cerebral cortex	J:209635
Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	abnormal seizure response to inducing agent	J:209635
	abnormal visual evoked potential	J:209635
	decreased locomotor activity	J:209635
	limb grasping	J:209635
	seizures	J:209635
Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr Tg(Thy1-YFP)#Jrs/0 involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA	abnormal dendrite morphology	J:209635
	abnormal hippocampus layer morphology	J:209635
	thin cerebral cortex	J:209635
	thin hippocampus molecular cell layer	J:209635
	thin hippocampus stratum oriens	J:209635
Cdkl5^tm1.2Cogr/Y Tg(Thy1-YFP)#Jrs/0 involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA	abnormal dendrite morphology	J:209635
	abnormal hippocampus layer morphology	J:209635
	thin cerebral cortex	J:209635
	thin hippocampus molecular cell layer	J:209635
	thin hippocampus stratum oriens	J:209635
Cdkl5^tm1.3Cogr/? involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J	abnormal behavior	J:209635
Cdkl5^tm1dIcs/Y C57BL/6N-Cdkl5^tm1dIcs/Ics	decreased respiratory quotient	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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