Cdkl5^tm1.3Cogr
Targeted Allele Detail

Summary

• Symbol: Cdkl5^tm1.3Cogr
• Name: cyclin dependent kinase like 5; targeted mutation 1.3, Cornelius Gross
• MGI ID: MGI:5573245
• Gene: Cdkl5 Location: ChrX:159567304-159777677 bp, - strand Genetic Position: ChrX, 73.95 cM
• Alliance: Cdkl5^tm1.3Cogr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209635
• Parent Cell Line: A8 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4, which was flanked by loxP sites 806 bp upstream and 347 bp downstream of the exon, has been deleted by cre recombinase; a FRT-flanked neomycin resistance cassette following the remaining loxP site is intact. (J:209635)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkl5 Mutation: 19 strains or lines available

Notes

According to EMMA, the parental ES cell line is A9, although ES cell line A8 was given in the original publication J:209635.

References

• Original: J:209635 Amendola E, et al., Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder. PLoS One. 2014;9(5):e91613
• All: 1 reference(s)