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Tyrobp
Gene Detail
 Symbol
Name
ID
Tyrobp
TYRO protein tyrosine kinase binding protein
MGI:1277211
Synonyms DAP12, KARAP, killer cell activating receptor associated protein
Feature Type protein coding gene
Genetic Map
Chromosome 7
17.45 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:30413788-30417577 bp, + strand
From Ensembl annotation of GRCm38

  3790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tyrobp

Human
homologs
Human Homolog TYROBP, TYRO protein tyrosine kinase binding protein
NCBI Gene ID 7305
neXtProt AC  NX_O43914
Human Synonyms  DAP12, KARAP, PLOSL
Human Chr (Location)  19q13.1; chr19:35904401-35908515 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TYROBP
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(15) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit osteopetrosis, hypomyelination (especially of the thalamus), synaptic degeneration, and impaired oligodendrocyte, NK, and dendritic cell function.
 
Human Diseases Modeled Using Mouse Tyrobp (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Tyrobp interacts with 16 markers (Mir10a, Mir10b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process integrin-mediated signaling pathway, macrophage activation involved in immune response, ...
Component cell surface, integral component of membrane, ...
Function identical protein binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (18)    Tissues (8)    Images (2)
Theiler Stages: 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 8
Northern blot 10
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(20) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030579 (Evidence)
Entrez Gene22177 (Evidence)
UniGene46301
DFCITC1582977
DoTSDT.530940
NIA Mouse Gene IndexU007928
Consensus CDS ProjectCCDS21089.1
International Mouse Knockout Project StatusTyrobp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030579 Ensembl Gene Model | MGI Sequence Detail 3790 C57BL/6J ±  kb
transcript ENSMUST00000032800 Ensembl | MGI Sequence Detail 564 Not Applicable 
polypeptide ENSMUSP00000032800 Ensembl | MGI Sequence Detail 114 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026200 TYRO protein tyrosine kinase-binding protein
Protein Ontology PR:000016879 TYRO protein tyrosine kinase-binding protein
References (Earliest) J:49202 Lanier LL, et al., Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells [see comments]. Nature. 1998 Feb 12;391(6668):703-7
(Latest) J:209371 Nabekura T, et al., Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection. Immunity. 2014 Feb 20;40(2):225-34
All references(131)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory