Tyrobp
Gene Detail

Symbol Name ID

Tyrobp TYRO protein tyrosine kinase binding protein MGI:1277211

Synonyms

DAP12, KARAP, killer cell activating receptor associated protein

Feature Type

protein coding gene

Genetic Map

Chromosome 7

17.45 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:30413788-30417577 bp, + strand From Ensembl annotation of GRCm38   3790 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tyrobp

Human homologs

Human Homolog		TYROBP, TYRO protein tyrosine kinase binding protein
NCBI Gene ID		7305
neXtProt AC		NX_O43914
Human Synonyms		DAP12, KARAP, PLOSL
Human Chr (Location)		19q13.1; chr19:36395303-36399211 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TYROBP

Alleles and phenotypes

All alleles(21) : Targeted(6) Gene trapped(15)
 

Homozygotes for targeted null mutations exhibit osteopetrosis, hypomyelination (especially of the thalamus), synaptic degeneration, and impaired oligodendrocyte, NK, and dendritic cell function.

 
Human Diseases Modeled Using Mouse Tyrobp (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	integrin-mediated signaling pathway, macrophage activation involved in immune response, ...
Component	integral to membrane, membrane
Function	identical protein binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (18)    Tissues (8)    Images (2)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	8
Northern blot	10

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(20) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030579 (Evidence)
Entrez Gene	22177 (Evidence)
UniGene	46301
DFCI	TC1582977
DoTS	DT.530940
NIA Mouse Gene Index	U007928
Consensus CDS Project	CCDS21089.1
International Mouse Knockout Project Status	Tyrobp

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030579	Ensembl Gene Model | MGI Sequence Detail	3790	C57BL/6J
transcript	ENSMUST00000032800	Ensembl | MGI Sequence Detail	564	Not Applicable
polypeptide	ENSMUSP00000032800	Ensembl | MGI Sequence Detail	114	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026200	TYRO protein tyrosine kinase-binding protein
Protein Ontology	PR:000016879	TYRO protein tyrosine kinase-binding protein

References

(Earliest) J:49202 Lanier LL, et al., Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells [see comments]. Nature. 1998 Feb 12;391(6668):703-7
(Latest) J:193006 Ishida-Kitagawa N, et al., Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J Biol Chem. 2012 May 18;287(21):17493-502
All references(120)