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Tyrobp Gene Detail
Summary
  • Symbol
    Tyrobp
  • Name
    TYRO protein tyrosine kinase binding protein
  • Synonyms
    DAP12, KARAP, killer cell activating receptor associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277211
    NCBI Gene: 22177
  • Gene Overview
    MyGene.info: TYROBP
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30413788-30417582 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 17.45 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277211
protein coding gene Chr7:30413760-30417585 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032017
protein coding gene Chr7:29399748-29403516 (+)
A/J MGP_AJ_G0031994
protein coding gene Chr7:28617698-28621494 (+)
AKR/J MGP_AKRJ_G0031927
protein coding gene Chr7:29348204-29351983 (+)
BALB/cJ MGP_BALBcJ_G0032001
protein coding gene Chr7:28796083-28799919 (+)
C3H/HeJ MGP_C3HHeJ_G0031720
protein coding gene Chr7:29793108-29796877 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032467
protein coding gene Chr7:30359575-30363785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029517
protein coding gene Chr7:29652706-29656279 (+)
CAST/EiJ MGP_CASTEiJ_G0031054
protein coding gene Chr7:23050089-23053847 (+)
CBA/J MGP_CBAJ_G0031686
protein coding gene Chr7:31807627-31811388 (+)
DBA/2J MGP_DBA2J_G0031838
protein coding gene Chr7:28347507-28351221 (+)
FVB/NJ MGP_FVBNJ_G0031795
protein coding gene Chr7:28466981-28470736 (+)
LP/J MGP_LPJ_G0031919
protein coding gene Chr7:29720343-29724111 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031831
protein coding gene Chr7:31056586-31062751 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032495
protein coding gene Chr7:28846767-28850698 (+)
PWK/PhJ MGP_PWKPhJ_G0030780
protein coding gene Chr7:23384592-23388560 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030613
protein coding gene Chr7:19853439-19857471 (+)
WSB/EiJ MGP_WSBEiJ_G0031164
protein coding gene Chr7:29231603-29235530 (+)



Homology
more
  • Human Ortholog
    TYROBP, TYRO protein tyrosine kinase binding protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TYROBP, TYRO protein tyrosine kinase binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DAP12, KARAP, PLOSL
  • Links
    NCBI Gene ID: 7305
    neXtProt AC: NX_O43914
    UniProt: O43914

  • Chr Location
    19q13.12; chr19:35904401-35908309 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tyrobp mouse models; 1 with human TYROBP associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 5 alleles in 8 genetic backgrounds
    29 phenotypes from multigenic genotypes
    2 images
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit osteopetrosis, hypomyelination (especially of the thalamus), synaptic degeneration, and impaired oligodendrocyte, NK, and dendritic cell function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22177 NCBI Gene Model | MGI Sequence Detail 3795 C57BL/6J ±  kb
    transcript NM_011662 RefSeq | MGI Sequence Detail 592 C57BL/6  
    polypeptide O54885 UniProt | EBI | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 21
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 12
      Phenotypes 103
    • Earliest
      J:49202 Lanier LL, et al., Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells [see comments]. Nature. 1998 Feb 12;391(6668):703-7
    • Latest
      J:239644 Yuan P, et al., TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 May 18;90(4):724-39

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory