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Tyrobp
Gene Detail
Symbol

Name
ID
Tyrobp
TYRO protein tyrosine kinase binding protein
MGI:1277211
Synonyms
DAP12, KARAP, killer cell activating receptor associated protein
Feature Type
protein coding gene
Genetic Map
Chromosome 7
17.45 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:30413788-30417577 bp, + strand
From Ensembl annotation of GRCm38

  3790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TYROBP
Gene Tree: Tyrobp

Human
homologs
TYROBP, TYRO protein tyrosine kinase binding protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7305
neXtProt AC: NX_O43914

Human Synonyms: DAP12, KARAP, PLOSL

Human Chr (Location): 19q13.1; chr19:35904401-35908309 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TYROBP

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(15) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit osteopetrosis, hypomyelination (especially of the thalamus), synaptic degeneration, and impaired oligodendrocyte, NK, and dendritic cell function.
 
Human Diseases Modeled in Mice Using Tyrobp (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Tyrobp interacts with 16 markers (Mir10a, Mir10b, Mir27a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (18)    Tissues (10)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
Northern blot 10
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100493958 ; ZFIN tyrobp    NEW 
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(20) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030579 (Evidence)
Entrez Gene 22177 (Evidence)
UniGene 46301
DFCI TC1582977
DoTS DT.530940
NIA Mouse Gene Index U007928
Consensus CDS Project CCDS21089.1
International Mouse Phenotyping Consortium Status Tyrobp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030579 Ensembl Gene Model | MGI Sequence Detail 3790 C57BL/6J ±  kb
transcript ENSMUST00000032800 Ensembl | MGI Sequence Detail 564 Not Applicable 
polypeptide ENSMUSP00000032800 Ensembl | MGI Sequence Detail 114 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026200 TYRO protein tyrosine kinase-binding protein
Protein Ontology PR:000016879 TYRO protein tyrosine kinase-binding protein
References
(Earliest) J:49202 Lanier LL, et al., Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells [see comments]. Nature. 1998 Feb 12;391(6668):703-7
(Latest) J:219657 Nabekura T, et al., Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation. J Exp Med. 2014 Nov 17;211(12):2455-65
All references(131)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory