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Atg5
Gene Detail
 Symbol
Name
ID
Atg5
autophagy related 5
MGI:1277186
Synonyms 2010107M05Rik, 3110067M24Rik, Apg5l, Paddy
Feature Type protein coding gene
Genetic Map
Chromosome 10
23.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:44268358-44364291 bp, + strand
From NCBI annotation of GRCm38

  95934 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3566  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Atg5

Human
homologs
Human Homolog ATG5, autophagy related 5
NCBI Gene ID 9474
neXtProt AC  NX_Q9H1Y0
Human Synonyms  APG5, APG5L, APG5-LIKE, ASP, hAPG5
Human Chr (Location)  6q21; chr6:106184476-106325820 (-)  GRCh38
Alleles
and
phenotypes
All alleles(24) : Gene trapped(22) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutation of this gene results in impaired autophagy due to absence of autolysosomes. Homozygotes die within 1 day of birth, have shorter survival times and reduced amino acid levels under fasting conditions. Homozygotes for a gene trap insertion mutation in this gene show no abnormal phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process apoptotic process, autophagic vacuole assembly, ...
Component autophagic vacuole, axoneme, ...
Function protein binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (42)    Tissues (28)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 42
cDNA source data(79)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(80) cDNA(80)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000038160 (Evidence)
Entrez Gene11793 (Evidence)
UniGene22264
DFCITC1575779, TC1740598
DoTSDT.494574, DT.94400199
NIA Mouse Gene IndexU011479
Consensus CDS ProjectCCDS23824.1
International Mouse Knockout Project StatusAtg5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11793 NCBI Gene Model | MGI Sequence Detail 95934 C57BL/6J ±  kb
transcript NM_053069 RefSeq | MGI Sequence Detail 2352 C57BL/6 
polypeptide Q99J83 UniProt | EBI | MGI Sequence Detail 275 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(293 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007239 Autophagy-related protein 5
Protein Ontology PR:000004418 autophagy protein 5
Graphical View of Protein Domain Structure
References (Earliest) J:48376 Pires-DaSilva A, et al., Gene trap insertion into a novel gene expressed during mouse limb development. Dev Dyn. 1998 Jun;212(2):318-25
(Latest) J:206800 Pirooz SD, et al., UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2716-21
All references(153)
Other
accession IDs
MGI:1277148, MGI:1917267, MGI:1920439, MGI:2143833, MGI:2143950

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory