Atg5
Gene Detail

Symbol Name ID

Atg5 autophagy related 5 MGI:1277186

Synonyms

2010107M05Rik, 3110067M24Rik, Apg5l, Paddy

Feature Type

protein coding gene

Genetic Map

Chromosome 10

23.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:44268358-44364291 bp, + strand From NCBI annotation of GRCm38   95934 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3566  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Atg5

Human homologs

Human Homolog		ATG5, autophagy related 5
NCBI Gene ID		9474
neXtProt AC		NX_Q9H1Y0
Human Synonyms		APG5, APG5L, APG5-LIKE, ASP, hAPG5
Human Chr (Location)		6q21; chr6:106632352-106773695 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(24) : Targeted(2) Gene trapped(22)
 

Mutation of this gene results in impaired autophagy due to absence of autolysosomes. Homozygotes die within 1 day of birth, have shorter survival times and reduced amino acid levels under fasting conditions. Homozygotes for a gene trap insertion mutation in this gene show no abnormal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	autophagic vacuole assembly, autophagy, ...
Component	autophagic vacuole, cytoplasm, ...
Function	protein binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (42)    Tissues (28)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	42

cDNA source data(79)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(80) cDNA(80)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000038160 (Evidence)
Entrez Gene	11793 (Evidence)
UniGene	22264
DFCI	TC1575779, TC1740598
DoTS	DT.494574, DT.94400199
NIA Mouse Gene Index	U011479
Consensus CDS Project	CCDS23824.1
International Mouse Knockout Project Status	Atg5

Sequences

Length	Strain/Species
genomic	11793	NCBI Gene Model | MGI Sequence Detail	95934	C57BL/6J
transcript	NM_053069	RefSeq | MGI Sequence Detail	2352	C57BL/6
polypeptide	Q99J83	UniProt | EBI | MGI Sequence Detail	275	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(270 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007239	Autophagy-related protein 5
Protein Ontology	PR:000004418	autophagy protein 5

Graphical View of Protein Domain Structure

References

(Earliest) J:48376 Pires-DaSilva A, et al., Gene trap insertion into a novel gene expressed during mouse limb development. Dev Dyn. 1998 Jun;212(2):318-25
(Latest) J:195093 Bae SH, et al., Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 2013 Jan 8;17(1):73-84
All references(125)

Other accession IDs

MGI:1277148, MGI:1917267, MGI:1920439, MGI:2143833, MGI:2143950