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Atg5
Gene Detail
Symbol

Name
ID
Atg5
autophagy related 5
MGI:1277186
Synonyms
2010107M05Rik, 3110067M24Rik, Apg5l, Paddy
Feature Type
protein coding gene
Genetic Map
Chromosome 10
23.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:44268358-44364291 bp, + strand
From Ensembl annotation of GRCm38

  95934 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3566  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATG5
Gene Tree: Atg5

Human
homologs
ATG5, autophagy related 5
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9474
neXtProt AC: NX_Q9H1Y0

Human Synonyms: APG5, APG5L, APG5-LIKE, ASP, hAPG5

Human Chr (Location): 6q21; chr6:106184476-106325820 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(22) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutation of this gene results in impaired autophagy due to absence of autolysosomes. Homozygotes die within 1 day of birth, have shorter survival times and reduced amino acid levels under fasting conditions. Homozygotes for a gene trap insertion mutation in this gene show no abnormal phenotype.
 
Phenotype Images(2)
Interactions
Atg5 interacts with 227 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process apoptotic process, autophagosome assembly, ...
Component Atg12-Atg5-Atg16 complex, autophagosome, ...
Function Atg8 ligase activity, protein binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (42)    Tissues (28)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(79)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atg5    NEW 
Molecular
reagents
All nucleic(80) cDNA(80)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000038160 (Evidence)
Entrez Gene 11793 (Evidence)
UniGene 22264
DFCI TC1575779, TC1740598
DoTS DT.94400199, DT.494574
NIA Mouse Gene Index U011479
Consensus CDS Project CCDS23824.1
International Mouse Phenotyping Consortium Status Atg5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038160 Ensembl Gene Model | MGI Sequence Detail 95934 C57BL/6J ±  kb
transcript ENSMUST00000039286 Ensembl | MGI Sequence Detail 2352 Not Applicable 
polypeptide ENSMUSP00000044769 Ensembl | MGI Sequence Detail 275 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(293 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007239 Autophagy-related protein 5
Protein Ontology PR:000004418 autophagy protein 5
References
(Earliest) J:48376 Pires-DaSilva A, et al., Gene trap insertion into a novel gene expressed during mouse limb development. Dev Dyn. 1998 Jun;212(2):318-25
(Latest) J:221407 Li F, et al., LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response. Cancer Cell. 2015 May 11;27(5):698-711
All references(172)
Other
accession IDs
MGI:1277148, MGI:1917267, MGI:1920439, MGI:2143833, MGI:2143950

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory