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Atg5 Gene Detail
Summary
  • Symbol
    Atg5
  • Name
    autophagy related 5
  • Synonyms
    2010107M05Rik, 3110067M24Rik, Apg5l, Paddy
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277186
    NCBI Gene: 11793
  • Gene Overview
    MyGene.info: ATG5
Location & Maps
more
  • Sequence Map
    Chr10:44268358-44364291 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      95934 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 23.24 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ATG5, autophagy related 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATG5, autophagy related 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APG5, APG5L, APG5-LIKE, ASP, hAPG5
  • Links
    NCBI Gene ID: 9474
    neXtProt AC: NX_Q9H1Y0

  • Chr Location
    6q21; chr6:106184476-106325820 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3566
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ATG5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 3 alleles in 14 genetic backgrounds
    8 phenotypes from multigenic genotypes
    2 images
    109 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Atg5
  • Incidental Mutations
Mutation of this gene results in impaired autophagy due to absence of autolysosomes. Homozygotes die within 1 day of birth, have shorter survival times and reduced amino acid levels under fasting conditions. Homozygotes for a gene trap insertion mutationin this gene show no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038160 Ensembl Gene Model | MGI Sequence Detail 95934 C57BL/6J ±  kb
transcript ENSMUST00000039286 Ensembl | MGI Sequence Detail 2352 Not Applicable  
polypeptide ENSMUSP00000044769 Ensembl | MGI Sequence Detail 275 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    294 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004418 autophagy protein 5
  • InterPro Domains
    IPR007239 Autophagy-related protein 5
Molecular
Reagents
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  • All nucleic 80
    cDNA 80

    Microarray probesets 5
Other
Accession IDs
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MGI:1277148, MGI:1917267, MGI:1920439, MGI:2143833, MGI:2143950
References
more
  • Summaries
    All 194
    Developmental Gene Expression 11
    Gene Ontology 28
    Phenotypes 109
  • Earliest
    J:48376 Pires-DaSilva A, et al., Gene trap insertion into a novel gene expressed during mouse limb development. Dev Dyn. 1998 Jun;212(2):318-25
  • Latest
    J:227714 Mizoguchi A, et al., Genetically engineered mouse models for studying inflammatory bowel disease. J Pathol. 2016 Jan;238(2):205-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory