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Atg5 Gene Detail
Summary
  • Symbol
    Atg5
  • Name
    autophagy related 5
  • Synonyms
    2010107M05Rik, 3110067M24Rik, Apg5l, Paddy
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277186
    NCBI Gene: 11793
  • Gene Overview
    MyGene.info: ATG5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:44268358-44364291 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      95934 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 23.24 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ATG5, autophagy related 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATG5, autophagy related 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APG5, APG5L, APG5-LIKE, ASP, hAPG5, SCAR25
  • Links
    NCBI Gene ID: 9474
    neXtProt AC: NX_Q9H1Y0
    UniProt: Q9H1Y0

  • Chr Location
    6q21; chr6:106184476-106325820 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3566
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ATG5
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ATG5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 3 alleles in 15 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    165 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutation of this gene results in impaired autophagy due to absence of autolysosomes. Homozygotes die within 1 day of birth, have shorter survival times and reduced amino acid levels under fasting conditions. Homozygotes for a gene trap insertion mutationin this gene show no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038160 Ensembl Gene Model | MGI Sequence Detail 95934 C57BL/6J ±  kb
    transcript ENSMUST00000039286 Ensembl | MGI Sequence Detail 2352 Not Applicable  
    polypeptide ENSMUSP00000044769 Ensembl | MGI Sequence Detail 275 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      294 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1277148, MGI:1917267, MGI:1920439, MGI:2143833, MGI:2143950
    References
    more
    • Summaries
      All 278
      Developmental Gene Expression 15
      Gene Ontology 28
      Phenotypes 165
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264744 Li Y, et al., Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation. Am J Pathol. 2018 Aug;188(8):1833-1846

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory