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Robo1
Gene Detail
Symbol

Name
ID
Robo1
roundabout homolog 1 (Drosophila)
MGI:1274781
Synonyms
DUTT1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
41.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:72663149-73046095 bp, + strand
From VEGA annotation of GRCm38

  382947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ROBO1
Gene Tree: Robo1

Human
homologs
ROBO1, roundabout, axon guidance receptor, homolog 1 (Drosophila)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6091
neXtProt AC: NX_Q9Y6N7

Human Synonyms: DUTT1, SAX3

Human Chr (Location): 3p12; chr3:78597238-79767998 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically induced (ENU)(1) Gene trapped(15) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia.
 
Human Diseases Modeled in Mice Using Robo1 (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(35)
Interactions
Robo1 interacts with 329 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (100 records)
Data Summary: Results (439)    Tissues (227)    Images (111)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 21
RNA in situ 396
Northern blot 13
RT-PCR 9
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ROBO1 ; Xenbase robo1 ; ZFIN robo1    NEW 
Molecular
reagents
All nucleic(30) cDNA(25) Primer pair(2) Other(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000017054 (Evidence)
Ensembl Gene Model ENSMUSG00000022883 (Evidence)
Entrez Gene 19876 (Evidence)
DFCI TC1646809, TC1609308, TC1632788, TC1602682, TC1622909, TC1596964, TC1690599
DoTS DT.91327495, DT.94251240, DT.87068728, DT.87049116, DT.87038274, DT.40160174
NIA Mouse Gene Index U043542
Consensus CDS Project CCDS37376.1
International Mouse Phenotyping Consortium Status Robo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017054 VEGA Gene Model | MGI Sequence Detail 382947 C57BL/6J ±  kb
transcript OTTMUST00000041308 VEGA | MGI Sequence Detail 7563 Not Applicable 
polypeptide OTTMUSP00000018540 VEGA | MGI Sequence Detail 1612 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(22) UniProt(6)
Polymorphisms
SNPs within 2kb(2255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000014151 roundabout homolog 1
References
(Earliest) J:47685 Sundaresan V, et al., The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. Mol Cell Neurosci. 1998 May;11(1-2):29-35
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(152)
Disease annotation references (2)
Other
accession IDs
MGI:2146645, MGI:2146674

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory