Robo1
Gene Detail

Symbol Name ID

Robo1 roundabout homolog 1 (Drosophila) MGI:1274781

Synonyms

DUTT1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

41.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:72663149-73046095 bp, + strand From VEGA annotation of GRCm38   382947 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Robo1

Human homologs

Human Homolog		ROBO1, roundabout, axon guidance receptor, homolog 1 (Drosophila)
NCBI Gene ID		6091
neXtProt AC		NX_Q9Y6N7
Human Synonyms		DUTT1, SAX3
Human Chr (Location)		3p12; chr3:78646388-79817059 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(21) : Targeted(6) Gene trapped(15)
 

Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia.

 
Human Diseases Modeled Using Mouse Robo1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, axon guidance, ...
Component	axolemma, axon, ...
Function	axon guidance receptor activity, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (84 records)
Data Summary: Results (354)    Tissues (148)    Images (82)
Theiler Stages: 10, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	17
RNA in situ	315
Northern blot	13
RT-PCR	9

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) cDNA(24) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000017054 (Evidence)
Ensembl Gene Model	ENSMUSG00000022883 (Evidence)
Entrez Gene	19876 (Evidence)
DFCI	TC1596964, TC1602682, TC1609308, TC1622909, TC1632788, TC1646809, TC1690599
DoTS	DT.40160174, DT.87038274, DT.87049116, DT.87068728, DT.91327495, DT.94251240
NIA Mouse Gene Index	U043542
Consensus CDS Project	CCDS37376.1
International Mouse Knockout Project Status	Robo1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017054	VEGA Gene Model | MGI Sequence Detail	382947	C57BL/6J
transcript	OTTMUST00000041308	VEGA | MGI Sequence Detail	7563	Not Applicable
polypeptide	OTTMUSP00000018540	VEGA | MGI Sequence Detail	1612	Not Applicable

All sequences(43) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(1927 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR003596	Immunoglobulin V-set, subgroup
Protein Ontology	PR:000014151	roundabout 1

References

(Earliest) J:47685 Sundaresan V, et al., The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. Mol Cell Neurosci. 1998 May;11(1-2):29-35
(Latest) J:193910 Bormuth I, et al., Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions. J Neurosci. 2013 Jan 9;33(2):641-51
All references(133)

Other accession IDs

MGI:2146645, MGI:2146674