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Robo1 Gene Detail
Summary
  • Symbol
    Robo1
  • Name
    roundabout guidance receptor 1
  • Synonyms
    DUTT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1274781
    NCBI Gene: 19876
  • Alliance
    genome feature page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:72105194-72842983 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 41.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23727 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1274781
 protein coding gene Chr16:71824406-72844379 (+)
129S1/SvImJ ENSMUSG00200008234
 protein coding gene Chr16:68981517-69725613 (+)
A/J ENSMUSG00195001579
 protein coding gene Chr16:68732811-69483552 (+)
AKR/J ENSMUSG00220005422
 protein coding gene Chr16:68916357-69666146 (+)
BALB/cJ ENSMUSG00180001588
 protein coding gene Chr16:68831436-69582110 (+)
C3H/HeJ ENSMUSG00175004474
 protein coding gene Chr16:69102984-69853668 (+)
C57BL/6NJ ENSMUSG00215012430
 protein coding gene Chr16:68948391-69686309 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020871
 protein coding gene Chr16:68028468-68405930 (+)
CAST/EiJ ENSTCUG00005012592
 protein coding gene Chr16:68894687-69629188 (+)
CBA/J ENSMUSG00210014980
 protein coding gene Chr16:69059844-69810483 (+)
DBA/2J ENSMUSG00185004528
 protein coding gene Chr16:68996307-69746943 (+)
FVB/NJ ENSMUSG00205011367
 protein coding gene Chr16:68728863-69480769 (+)
JF1/MsJ ENSUMUG00000014215
 protein coding gene Chr16:69216567-69939325 (+)
LP/J ENSMUSG00230007096
 protein coding gene Chr16:71560721-72304791 (+)
NOD/ShiLtJ ENSMUSG00190016332
 protein coding gene Chr16:68956837-69714319 (+)
NZO/HlLtJ ENSMUSG00225029365
 protein coding gene Chr16:74796686-75540736 (+)
PWK/PhJ ENSLUMG00010011253
 protein coding gene Chr16:68907973-69637031 (+)
SPRET/EiJ ENSMSPG00010002002
 protein coding gene Chr16:69639427-70398439 (+)
WSB/EiJ ENSIUOG00005002307
 protein coding gene Chr16:68977119-69719730 (+)



Homology
more
  • Human Ortholog
    ROBO1, roundabout guidance receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROBO1, roundabout guidance receptor 1
  • Synonyms
    CPHD8, DUTT1, NORS, NYS8, SAX3
  • Links
    NCBI Gene ID: 6091
    UniProt: Q9Y6N7

  • Chr Location
    3p12.3; chr3:78597239-79767998 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Robo1 mouse models; 4 with human ROBO1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 6 alleles in 8 genetic backgrounds
    23 phenotypes from multigenic genotypes
    35 images
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for one null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia. Homozygotes for an ENU-induced mutation display craniofacial and cardiac anomalies and polycystic kidneys.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1340
  • Tissues
    372
  • cDNA Data
    22
  • Literature Summary
    155
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022883 Ensembl Gene Model | MGI Sequence Detail 737790 C57BL/6J ±  kb
    transcript ENSMUST00000232205 Ensembl | MGI Sequence Detail 6601 Not Applicable  
    polypeptide ENSMUSP00000155958 Ensembl | MGI Sequence Detail 1622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 34
      Primer pair 7
      Other 11
      Antibodies 18

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2146645, MGI:2146674
    References
    more
    • Summaries
      All 264
      Developmental Gene Expression 155
      Diseases 2
      Gene Ontology 18
      Phenotypes 107
    • Earliest
      J:47685 Sundaresan V, et al., The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. Mol Cell Neurosci. 1998 May;11(1-2):29-35
    • Latest
      J:388639 Li Z, et al., Adaptive evolution of gene regulatory networks in mammalian neocortex. Nature. 2026 May;653(8113):156-166
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory