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Robo1 Gene Detail
Summary
  • Symbol
    Robo1
  • Name
    roundabout guidance receptor 1
  • Synonyms
    DUTT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1274781
    NCBI Gene: 19876
  • Gene Overview
    MyGene.info: ROBO1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:72308306-73046095 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 41.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7928 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1274781
protein coding gene Chr16:72027551-73047491 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022950
protein coding gene Chr16:72564820-72961641 (+)
A/J MGP_AJ_G0022918
protein coding gene Chr16:69366431-69751940 (+)
AKR/J MGP_AKRJ_G0022888
protein coding gene Chr16:71477955-71864130 (+)
BALB/cJ MGP_BALBcJ_G0022920
protein coding gene Chr16:69698817-70091442 (+)
C3H/HeJ MGP_C3HHeJ_G0022682
protein coding gene Chr16:71902145-72306186 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023368
protein coding gene Chr16:74886426-75304308 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020871
protein coding gene Chr16:68028468-68405930 (+)
CAST/EiJ MGP_CASTEiJ_G0022205
protein coding gene Chr16:72269730-72700469 (+)
CBA/J MGP_CBAJ_G0022652
protein coding gene Chr16:78056970-78495283 (+)
DBA/2J MGP_DBA2J_G0022785
protein coding gene Chr16:69214217-69598406 (+)
FVB/NJ MGP_FVBNJ_G0022760
protein coding gene Chr16:68609338-68986055 (+)
LP/J MGP_LPJ_G0022855
protein coding gene Chr16:72350001-72756553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022778
protein coding gene Chr16:80763521-81190540 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023385
protein coding gene Chr16:71751343-72148300 (+)
PWK/PhJ MGP_PWKPhJ_G0021947
protein coding gene Chr16:69442822-69863889 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021777
protein coding gene Chr16:71416662-71826264 (+)
WSB/EiJ MGP_WSBEiJ_G0022252
protein coding gene Chr16:71926708-72327549 (+)



Homology
more
  • Human Ortholog
    ROBO1, roundabout guidance receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ROBO1, roundabout guidance receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DUTT1, SAX3
  • Links
    NCBI Gene ID: 6091
    neXtProt AC: NX_Q9Y6N7
    UniProt: Q9Y6N7

  • Chr Location
    3p12.3; chr3:78597238-79767998 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2206
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ROBO1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Robo1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 5 alleles in 6 genetic backgrounds
    22 phenotypes from multigenic genotypes
    35 images
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022883 Ensembl Gene Model | MGI Sequence Detail 737790 C57BL/6J ±  kb
    transcript ENSMUST00000232205 Ensembl | MGI Sequence Detail 6601 Not Applicable  
    polypeptide ENSMUSP00000155958 Ensembl | MGI Sequence Detail 1622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 30
      Primer pair 6
      Other 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2146645, MGI:2146674
    References
    more
    • Summaries
      All 191
      Developmental Gene Expression 121
      Diseases 2
      Gene Ontology 13
      Phenotypes 68
    • Earliest
      J:47685 Sundaresan V, et al., The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. Mol Cell Neurosci. 1998 May;11(1-2):29-35
    • Latest
      J:266538 Backer S, et al., Trio GEF mediates RhoA activation downstream of Slit2 and coordinates telencephalic wiring. Development. 2018 Oct 2;145(19)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory