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Robo1
Gene Detail
 Symbol
Name
ID
Robo1
roundabout homolog 1 (Drosophila)
MGI:1274781
Synonyms DUTT1
Feature Type protein coding gene
Genetic Map
Chromosome 16
41.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:72663149-73046095 bp, + strand
From VEGA annotation of GRCm38

  382947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Robo1

Human
homologs
Human Homolog ROBO1, roundabout, axon guidance receptor, homolog 1 (Drosophila)
NCBI Gene ID 6091
neXtProt AC  NX_Q9Y6N7
Human Synonyms  DUTT1, SAX3
Human Chr (Location)  3p12; chr3:78597238-79767909 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically induced (ENU)(1) Gene trapped(15) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia.
 
Human Diseases Modeled Using Mouse Robo1 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(35)
Interactions
Robo1 interacts with 330 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, axon guidance, ...
Component axolemma, axon, ...
Function axon guidance receptor activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (90 records)
Data Summary: Results (425)    Tissues (213)    Images (107)
Theiler Stages: 10, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 21
RNA in situ 382
Northern blot 13
RT-PCR 9
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(25) Primer pair(2) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000017054 (Evidence)
Ensembl Gene ModelENSMUSG00000022883 (Evidence)
Entrez Gene19876 (Evidence)
DFCITC1596964, TC1602682, TC1609308, TC1622909, TC1632788, TC1646809, TC1690599
DoTSDT.40160174, DT.87038274, DT.87049116, DT.87068728, DT.91327495, DT.94251240
NIA Mouse Gene IndexU043542
Consensus CDS ProjectCCDS37376.1
International Mouse Knockout Project StatusRobo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017054 VEGA Gene Model | MGI Sequence Detail 382947 C57BL/6J ±  kb
transcript OTTMUST00000041308 VEGA | MGI Sequence Detail 7563 Not Applicable 
polypeptide OTTMUSP00000018540 VEGA | MGI Sequence Detail 1612 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(22) UniProt(7)
Polymorphisms SNPs within 2kb(2255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR003596 Immunoglobulin V-set, subgroup
Protein Ontology PR:000014151 roundabout homolog 1
References (Earliest) J:47685 Sundaresan V, et al., The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. Mol Cell Neurosci. 1998 May;11(1-2):29-35
(Latest) J:210623 Yeh ML, et al., Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014 Apr 16;34(16):5717-31
All references(142)
Disease annotation references (2)
Other
accession IDs
MGI:2146645, MGI:2146674

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory