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Il12rb2 Gene Detail
Summary
  • Symbol
    Il12rb2
  • Name
    interleukin 12 receptor, beta 2
  • Synonyms
    A930027I18Rik, Ifnm, IL-12RB2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270861
    NCBI Gene: 16162
Location & Maps
more
  • Sequence Map
    Chr6:67291318-67376188 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      84871 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IL12RB2, interleukin 12 receptor subunit beta 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IL12RB2, interleukin 12 receptor subunit beta 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 3595
    neXtProt AC: NX_Q99665

  • Chr Location
    1p31.3-p31.2; chr1:67307351-67396900 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have defects in IFN-gamma production and cytotoxic T lymphocyte and NK cytotoxicity, develop an autoimmune/lymphoproliferative disorder associated with higher susceptibility to spontaneous tumor formation, but show reduced in vivo growth of B16 melanoma tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029293 VEGA Gene Model | MGI Sequence Detail 84871 C57BL/6J ±  kb
transcript OTTMUST00000072591 VEGA | MGI Sequence Detail 2998 Not Applicable  
polypeptide OTTMUSP00000037409 VEGA | MGI Sequence Detail 874 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    531 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008980 interleukin-12 receptor subunit beta-2
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR010457 Immunoglobulin C2-set-like, ligand-binding
    IPR013783 Immunoglobulin-like fold
    IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Molecular
Reagents
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  • All nucleic 15
    Genomic 6
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
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MGI:1924481, MGI:2152339
References
more
  • Summaries
    All 98
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 64
  • Earliest
    J:37050 Presky DH, et al., A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14002-7
  • Latest
    J:226557 Shah S, et al., An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory