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Pibf1 Gene Detail
Summary
  • Symbol
    Pibf1
  • Name
    progesterone immunomodulatory binding factor 1
  • Synonyms
    1700017E21Rik, 4930513H15Rik, 4933438D16Rik, 4933439E17Rik, D14Ertd581e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261910
    NCBI Gene: 52023
  • Gene Overview
    MyGene.info: PIBF1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:99099424-99254493 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 49.27 cM, cytoband E2.1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1509 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261910
protein coding gene Chr14:99099424-99254494 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021617
protein coding gene Chr14:95371800-95533047 (+)
A/J MGP_AJ_G0021575
protein coding gene Chr14:92334379-92491043 (+)
AKR/J MGP_AKRJ_G0021551
protein coding gene Chr14:95048816-95214154 (+)
BALB/cJ MGP_BALBcJ_G0021581
protein coding gene Chr14:92666896-92829311 (+)
C3H/HeJ MGP_C3HHeJ_G0021359
protein coding gene Chr14:94935802-95099047 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022021
protein coding gene Chr14:99265610-99436224 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019561
protein coding gene Chr14:89383476-89543010 (+)
CAST/EiJ MGP_CASTEiJ_G0020876
protein coding gene Chr14:92227318-92390909 (+)
CBA/J MGP_CBAJ_G0021327
protein coding gene Chr14:102940990-103119911 (+)
DBA/2J MGP_DBA2J_G0021451
protein coding gene Chr14:91828079-91984161 (+)
FVB/NJ MGP_FVBNJ_G0021428
protein coding gene Chr14:90865778-91025543 (+)
LP/J MGP_LPJ_G0021519
protein coding gene Chr14:96176615-96335586 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021455
protein coding gene Chr14:105663247-105837091 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022044
protein coding gene Chr14:94558053-94724762 (+)
PWK/PhJ MGP_PWKPhJ_G0020619
protein coding gene Chr14:88808735-88969098 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020457
protein coding gene Chr14:90529706-90698644 (+)
WSB/EiJ MGP_WSBEiJ_G0020929
protein coding gene Chr14:95160546-95326544 (+)



Homology
more
  • Human Ortholog
    PIBF1, progesterone immunomodulatory binding factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIBF1, progesterone immunomodulatory binding factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C13orf24, CEP90, JBTS33, PIBF
  • Links
    NCBI Gene ID: 10464
    neXtProt AC: NX_Q8WXW3
    UniProt: Q8WXW3

  • Chr Location
    13q21.33-q22.1; chr13:72782059-73016454 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4628
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PIBF1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PIBF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022064 Ensembl Gene Model | MGI Sequence Detail 155070 C57BL/6J ±  kb
    transcript ENSMUST00000022650 Ensembl | MGI Sequence Detail 2797 Not Applicable  
    polypeptide ENSMUSP00000022650 Ensembl | MGI Sequence Detail 756 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR026205 Progesterone-induced-blocking factor 1
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 29
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918542, MGI:1918565, MGI:1922765, MGI:1923071
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 1
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:251027 Huang B, et al., Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor. Nat Med. 2017 Jan;23(1):128-135

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory