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Dnmt3b Gene Detail
Summary
  • Symbol
    Dnmt3b
  • Name
    DNA methyltransferase 3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261819
    NCBI Gene: 13436
  • Gene Overview
    MyGene.info: DNMT3B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:153649450-153687730 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38281 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.79 cM, cytoband A2-A3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DNMT3B, DNA methyltransferase 3 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DNMT3B, DNA methyltransferase 3 beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ICF, ICF1, M.HsaIIIB
  • Links
    NCBI Gene ID: 1789
    neXtProt AC: NX_Q9UBC3
    UniProt: Q9UBC3

  • Chr Location
    20q11.21; chr20:32762385-32809356 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dnmt3b mouse models; 1 with human DNMT3B associations

Human Disease Mouse Models
      
IDs
View 7 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 8 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit growth retardation and rostral neural tube defects, and die prenatally. Mutants exhibit slight under-methylation of endogenous viral DNA and substantial demethylation of minor satellite DNA.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016775 VEGA Gene Model | MGI Sequence Detail 38281 C57BL/6J ±  kb
    transcript OTTMUST00000040855 VEGA | MGI Sequence Detail 3630 Not Applicable  
    polypeptide OTTMUSP00000018276 VEGA | MGI Sequence Detail 860 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      300 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 15
      Primer pair 13
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 49
      Diseases 2
      Gene Ontology 28
      Phenotypes 43
    • Earliest
      J:48528 Okano M, et al., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet. 1998 Jul;19(3):219-20
    • Latest
      J:259618 Hatazawa Y, et al., Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration. FASEB J. 2018 Mar;32(3):1452-1467

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory