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Dnmt3b
Gene Detail
Symbol

Name
ID
Dnmt3b
DNA methyltransferase 3B
MGI:1261819
Feature Type
protein coding gene
Genetic Map
Chromosome 2
75.79 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:153649450-153687730 bp, + strand
From VEGA annotation of GRCm38

  38281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56000  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: DNMT3B
Protein SuperFamily: DNA (cytosine-5)-methyltransferase 3B, Dnmt3b type
Gene Tree: Dnmt3b

Human
homologs
DNMT3B, DNA (cytosine-5-)-methyltransferase 3 beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1789
neXtProt AC: NX_Q9UBC3

Human Synonyms: ICF, ICF1, M.HsaIIIB

Human Chr (Location): 20q11.2; chr20:32762385-32809356 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DNMT3B

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Chemically induced (ENU)(1) Gene trapped(26) Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit growth retardation and rostral neural tube defects, and die prenatally. Mutants exhibit slight under-methylation of endogenous viral DNA and substantial demethylation of minor satellite DNA.
 
Human Diseases Modeled in Mice Using Dnmt3b (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Dnmt3b interacts with 238 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process C-5 methylation of cytosine, cellular response to amino acid stimulus, ...
Component chromosome, centromeric region, cytoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (943)    Tissues (637)    Images (128)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 45
RNA in situ 712
Northern blot 46
Western blot 6
RT-PCR 134
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DNMT3B ZFIN dnmt3ba    NEW 
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(14) Primer pair(12) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016775 (Evidence)
Ensembl Gene Model ENSMUSG00000027478 (Evidence)
Entrez Gene 13436 (Evidence)
DFCI TC1595413, TC1596452, TC1588244, TC1595025, TC1651673, TC1602863, TC1611556
DoTS DT.101394308, DT.101737914, DT.101394309, DT.91492688, DT.91601015, DT.97373081, DT.94123870, DT.97373080
NIA Mouse Gene Index U002667
EC 2.1.1.37
PDB 1KHC
Consensus CDS Project CCDS16913.1, CCDS16914.1, CCDS16915.1, CCDS16916.1, CCDS50759.1
International Mouse Phenotyping Consortium Status Dnmt3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016775 VEGA Gene Model | MGI Sequence Detail 38281 C57BL/6J ±  kb
transcript OTTMUST00000040855 VEGA | MGI Sequence Detail 3630 Not Applicable 
polypeptide OTTMUSP00000018276 VEGA | MGI Sequence Detail 860 Not Applicable 

For the selected sequences
All sequences(119) RefSeq(35) UniProt(3)
Polymorphisms
SNPs within 2kb(329 from dbSNP Build 137)    SNPs within 2kb including multiple locations(385)
Protein-related
information
ResourceIDDescription
InterPro IPR025766 ADD domain
InterPro IPR001525 C-5 cytosine methyltransferase
InterPro IPR018117 DNA methylase, C-5 cytosine-specific, active site
InterPro IPR000313 PWWP
InterPro IPR011011 Zinc finger, FYVE/PHD-type
Protein Ontology PR:000006608 DNA (cytosine-5)-methyltransferase 3B
References
(Earliest) J:48528 Okano M, et al., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet. 1998 Jul;19(3):219-20
(Latest) J:219587 Geula S, et al., Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science. 2015 Feb 27;347(6225):1002-6
All references(131)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory