Myo15
Gene Detail

Symbol Name ID

Myo15 myosin XV MGI:1261811

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr11:60469339-60528369 bp, + strand From VEGA annotation of GRCm38   59031 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Myo15

Human homologs

Human Homolog		MYO15A, myosin XVA
NCBI Gene ID		51168
neXtProt AC		NX_Q9UKN7
Human Synonyms		DFNB3, MYO15
Human Chr (Location)		17p11.2; chr17:18012020-18083116 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYO15A

Alleles and phenotypes

All alleles(7) : Targeted(3) Spontaneous(2) Chemically induced(1) Radiation induced(1)
 

Mutations in this gene result in profound deafness and neurological behavior.

 
Human Diseases Modeled Using Mouse Myo15 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	inner ear morphogenesis, locomotory behavior, ...
Component	cell projection, cytoplasm, ...
Function	actin binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (48)    Tissues (23)    Images (4)
Theiler Stages: 10, 18, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	12
Northern blot	18
RT-PCR	15

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(2) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000005818 (Evidence)
Ensembl Gene Model	ENSMUSG00000042678 (Evidence)
Entrez Gene	17910 (Evidence)
UniGene	89960
DFCI	TC1591164, TC1596785
DoTS	DT.101724347, DT.91329627, DT.97353459
NIA Mouse Gene Index	U012696
Consensus CDS Project	CCDS24792.1, CCDS24793.1, CCDS48811.1
International Mouse Knockout Project Status	Myo15

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005818	VEGA Gene Model | MGI Sequence Detail	59031	C57BL/6J
transcript	OTTMUST00000012896	VEGA | MGI Sequence Detail	11769	Not Applicable
polypeptide	OTTMUSP00000005997	VEGA | MGI Sequence Detail	3511	Not Applicable

All sequences(41) RefSeq(6) UniProt(2)

Polymorphisms

SNPs(208 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR019748	FERM central domain
InterPro	IPR000299	FERM domain
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR001609	Myosin head, motor domain
InterPro	IPR000857	MyTH4 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
Protein Ontology	PR:000010850	myosin-XV

References

(Earliest) J:15021 Dobrovolskaia-Zavasdkaia N, L'irradiation des testicules et l'heredite chez la souris. Arch Biol (Liege). 1928;38:457-501
(Latest) J:189624 Son EJ, et al., Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735
All references(82)

Other accession IDs

MGD-MRK-14392, MGD-MRK-14394, MGI:98292