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Myo15 Gene Detail
Summary
  • Symbol
    Myo15
  • Name
    myosin XV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261811
    NCBI Gene: 17910
  • Gene Overview
    MyGene.info: MYO15A
Location & Maps
more
  • Sequence Map
    Chr11:60469339-60528369 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59031 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    MYO15A, myosin XVA
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYO15A, myosin XVA
    Orthology source: HomoloGene
  • Synonyms
    DFNB3, MYO15
  • Links
    NCBI Gene ID: 51168
    neXtProt AC: NX_Q9UKN7

  • Chr Location
    17p11.2; chr17:18108706-18180225 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56504
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MYO15A
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Myo15 mouse models; 1 with human MYO15A associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 3; DFNB3   OMIM: 600316 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 5 alleles in 6 genetic backgrounds
    24 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Myo15
  • Incidental Mutations
Mutations in this gene result in profound deafness and neurological behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005818 VEGA Gene Model | MGI Sequence Detail 59031 C57BL/6J ±  kb
transcript OTTMUST00000012896 VEGA | MGI Sequence Detail 11769 Not Applicable  
polypeptide OTTMUSP00000005997 VEGA | MGI Sequence Detail 3511 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    434 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 13
    Primer pair 3
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-14392, MGD-MRK-14394, MGI:98292
References
more
  • Summaries
    All 84
    Developmental Gene Expression 16
    Diseases 3
    Gene Ontology 10
    Phenotypes 52
  • Earliest
    J:15021 Dobrovolskaia-Zavasdkaia N, L'irradiation des testicules et l'heredite chez la souris. Arch Biol (Liege). 1928;38:457-501
  • Latest
    J:214077 Bird JE, et al., Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12390-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory