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Myo15
Gene Detail
Symbol

Name
ID
Myo15
myosin XV
MGI:1261811
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr11:60469339-60528369 bp, + strand
From VEGA annotation of GRCm38

  59031 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYO15A
Gene Tree: Myo15

Human
homologs
MYO15A, myosin XVA
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51168
neXtProt AC: NX_Q9UKN7

Human Synonyms: DFNB3, MYO15

Human Chr (Location): 17p11.2; chr17:18108706-18180225 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MYO15A

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Radiation induced(1) Spontaneous(2) Targeted(5)
Genomic Mutations involving Myo15 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this gene result in profound deafness and neurological behavior.
 
Human Diseases Modeled in Mice Using Myo15 (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Myo15 interacts with 206 markers (Mir1b, Mir22, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process inner ear morphogenesis, locomotory behavior, ...
Component cell projection, cytoplasm, ...
Function actin binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (48)    Tissues (24)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 12
Northern blot 18
RT-PCR 15
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN myo15aa    NEW 
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000005818 (Evidence)
Ensembl Gene Model ENSMUSG00000042678 (Evidence)
Entrez Gene 17910 (Evidence)
UniGene 89960
DFCI TC1591164, TC1596785
DoTS DT.91329627, DT.101724347, DT.97353459
NIA Mouse Gene Index U012696
Consensus CDS Project CCDS24792.1, CCDS24793.1, CCDS48811.1
International Mouse Phenotyping Consortium Status Myo15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005818 VEGA Gene Model | MGI Sequence Detail 59031 C57BL/6J ±  kb
transcript OTTMUST00000012896 VEGA | MGI Sequence Detail 11769 Not Applicable 
polypeptide OTTMUSP00000005997 VEGA | MGI Sequence Detail 3511 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(435 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019748 FERM central domain
InterPro IPR000299 FERM domain
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR000857 MyTH4 domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000010850 myosin-XV
References
(Earliest) J:15021 Dobrovolskaia-Zavasdkaia N, L'irradiation des testicules et l'heredite chez la souris. Arch Biol (Liege). 1928;38:457-501
(Latest) J:195357 Roeseler DA, et al., Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2. PLoS One. 2012;7(11):e47366
All references(86)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14392, MGD-MRK-14394, MGI:98292

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory