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Myo15
Gene Detail
Symbol

Name
ID
Myo15
myosin XV
MGI:1261811
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr11:60469339-60528369 bp, + strand
From VEGA annotation of GRCm38

  59031 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Myo15

Human
homologs
Human Homolog MYO15A, myosin XVA
NCBI Gene ID 51168
neXtProt AC  NX_Q9UKN7
Human Synonyms  DFNB3, MYO15
Human Chr (Location)  17p11.2; chr17:18108706-18179802 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYO15A
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Radiation induced(1) Spontaneous(2) Targeted(5)
Genomic Mutations involving Myo15 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in profound deafness and neurological behavior.
 
Human Diseases Modeled Using Mouse Myo15 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Myo15 interacts with 207 markers (Mir1b, Mir22, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process inner ear morphogenesis, locomotory behavior, ...
Component cell projection, cytoplasm, ...
Function actin binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (48)    Tissues (24)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 12
Northern blot 18
RT-PCR 15
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000005818 (Evidence)
Ensembl Gene ModelENSMUSG00000042678 (Evidence)
Entrez Gene17910 (Evidence)
UniGene89960
DFCITC1596785, TC1591164
DoTSDT.97353459, DT.91329627, DT.101724347
NIA Mouse Gene IndexU012696
Consensus CDS ProjectCCDS24792.1, CCDS24793.1, CCDS48811.1
International Mouse Knockout Project StatusMyo15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005818 VEGA Gene Model | MGI Sequence Detail 59031 C57BL/6J ±  kb
transcript OTTMUST00000012896 VEGA | MGI Sequence Detail 11769 Not Applicable 
polypeptide OTTMUSP00000005997 VEGA | MGI Sequence Detail 3511 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(27) UniProt(3)
Polymorphisms
SNPs within 2kb(435 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019748 FERM central domain
InterPro IPR000299 FERM domain
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR000857 MyTH4 domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000010850 myosin-XV
References
(Earliest) J:15021 Dobrovolskaia-Zavasdkaia N, L'irradiation des testicules et l'heredite chez la souris. Arch Biol (Liege). 1928;38:457-501
(Latest) J:195357 Roeseler DA, et al., Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2. PLoS One. 2012;7(11):e47366
All references(86)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14392, MGD-MRK-14394, MGI:98292

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory