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Targeted Allele Detail
Symbol: Myo15atm1.1Jebd
Name: myosin XVA; targeted mutation 1.1, Jonathan E Bird
MGI ID: MGI:5806093
Synonyms: Myo15deltaN, Myo15E1086X
Gene: Myo15a  Location: Chr11:60360165-60419195 bp, + strand  Genetic Position: Chr11, 37.81 cM
Alliance: Myo15atm1.1Jebd page
Germline Transmission:  Earliest citation of germline transmission: J:226820
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 2 was replaced with a modified one in which nucleotide substitutions (GAG to TAA) results in the amino acid susbtitution of a stop codon for glutamic acid. This mutation affects isoform 1 but not isoform 2. Cre-mediated recombination removed the selection cassette. (J:226820)
View phenotypes and curated references for all genotypes (concatenated display).
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myo15a Mutation:  88 strains or lines available
Original:  J:226820 Fang Q, et al., The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing. Elife. 2015;4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory