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Suz12
Gene Detail
 Symbol
Name
ID
Suz12
suppressor of zeste 12 homolog (Drosophila)
MGI:1261758
Synonyms 2610028O16Rik, D11Ertd530e, mKIAA0160
Feature Type protein coding gene
Genetic Map
Chromosome 11
47.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:79993106-80034123 bp, + strand
From VEGA annotation of GRCm38

  41018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Suz12

Human
homologs
Human Homolog SUZ12, SUZ12 polycomb repressive complex 2 subunit
NCBI Gene ID 23512
neXtProt AC  NX_Q15022
Human Synonyms  CHET9, JJAZ1
Human Chr (Location)  17q11.2; chr17:31937025-32001045 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Chemically induced (ENU)(1) Gene trapped(32) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die during early postimplantation stages with failure of embryonic and extraembyronic tissues and organogenesis. Mice heterozygous for a knock-out allele exhibit abnormal brain and spinal cord development with varying penetrance.
 
Interactions
Suz12 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process chromatin modification, histone methylation, ...
Component chromosome, ESC/E(Z) complex, ...
Function chromatin binding, histone methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (97)    Tissues (32)    Images (29)
Theiler Stages: 10, 13, 17, 20, 22, 23, 24, 27, 28
Assay TypeResults
RNA in situ 89
RT-PCR 8
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(22) Primer pair(2)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000000192 (Evidence)
Ensembl Gene ModelENSMUSG00000017548 (Evidence)
Entrez Gene52615 (Evidence)
DFCITC1572019, TC1771013, TC1776164
NIA Mouse Gene IndexU013044, U338402
Consensus CDS ProjectCCDS25125.1, CCDS48860.1
International Mouse Knockout Project StatusSuz12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000192 VEGA Gene Model | MGI Sequence Detail 41018 C57BL/6J ±  kb
transcript OTTMUST00000000571 VEGA | MGI Sequence Detail 4373 Not Applicable 
polypeptide OTTMUSP00000000248 VEGA | MGI Sequence Detail 741 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019135 Polycomb protein, VEFS-Box
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000015848 polycomb protein SUZ12
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:206847 Neri F, et al., Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs. Cell. 2013 Sep 26;155(1):121-34
All references(76)
Other
accession IDs
MGI:1922065, MGI:2144085, MGI:2144379, MGI:2144551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory