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Suz12
Gene Detail
Symbol

Name
ID
Suz12
suppressor of zeste 12 homolog (Drosophila)
MGI:1261758
Synonyms
2610028O16Rik, D11Ertd530e, mKIAA0160
Feature Type
protein coding gene
Genetic Map
Chromosome 11
47.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:79993106-80034123 bp, + strand
From VEGA annotation of GRCm38

  41018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SUZ12
Gene Tree: Suz12

Human
homologs
SUZ12, SUZ12 polycomb repressive complex 2 subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23512
neXtProt AC: NX_Q15022

Human Synonyms: CHET9, JJAZ1

Human Chr (Location): 17q11.2; chr17:31937025-32001045 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Chemically induced (ENU)(1) Gene trapped(32) Targeted(6)
Genomic Mutations involving Suz12 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice die during early postimplantation stages with failure of embryonic and extraembyronic tissues and organogenesis. Mice heterozygous for a knock-out allele exhibit abnormal brain and spinal cord development with varying penetrance.
 
Interactions
Suz12 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process chromatin modification, histone H3-K27 trimethylation, ...
Component chromosome, ESC/E(Z) complex, ...
Function chromatin binding, chromatin DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (97)    Tissues (32)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 89
RT-PCR 8
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase suz12 ; ZFIN suz12a, suz12b    NEW 
Molecular
reagents
All nucleic(24) cDNA(22) Primer pair(2)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000000192 (Evidence)
Ensembl Gene Model ENSMUSG00000017548 (Evidence)
Entrez Gene 52615 (Evidence)
DFCI TC1572019, TC1771013, TC1776164
NIA Mouse Gene Index U013044, U338402
Consensus CDS Project CCDS25125.1, CCDS48860.1
International Mouse Phenotyping Consortium Status Suz12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000192 VEGA Gene Model | MGI Sequence Detail 41018 C57BL/6J ±  kb
transcript OTTMUST00000000571 VEGA | MGI Sequence Detail 4373 Not Applicable 
polypeptide OTTMUSP00000000248 VEGA | MGI Sequence Detail 741 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019135 Polycomb protein, VEFS-Box
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000015848 polycomb protein SUZ12
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:218234 Wurm S, et al., Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev. 2015 Jan 15;29(2):144-56
All references(86)
Other
accession IDs
MGI:1922065, MGI:2144085, MGI:2144379, MGI:2144551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory