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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Suz12
SUZ12 polycomb repressive complex 2 subunit
MGI:1261758
26 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Mpltm1Wsa/\Mpltm1Wsa
\Suz12Gt(Betageo)1Khe/\Suz12+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		abnormal thrombopoiesis J:136262
increased leukocyte cell number J:136262
increased lymphocyte cell number J:136262
thrombocytopenia J:136262
\Mpltm1Wsa/\Mpltm1Wsa
\Suz12Plt8/\Suz12+
B6.Cg-Mpltm1Wsa Suz12Plt8 		abnormal bone marrow cell morphology/development J:136262
abnormal megakaryocyte differentiation J:136262
abnormal thrombopoiesis J:136262
increased leukocyte cell number J:136262
increased lymphocyte cell number J:136262
thrombocytopenia J:136262
\Mpltm1Wsa/\Mpltm1Wsa
\Suz12Plt8/\Suz12Plt8
B6.Cg-Mpltm1Wsa Suz12Plt8 		decreased embryo size J:136262
prenatal lethality, complete penetrance J:136262
\Mtf2tm1.1Hko/\Mtf2tm1.1Hko
\Suz12tm1Hko/\Suz12+
involves: C57BL/6 		abnormal sternum morphology J:170279
cervical vertebral transformation J:170279
increased rib number J:170279
lumbar vertebral transformation J:170279
thoracic vertebral transformation J:170279
vertebral transformation J:170279
\Nf1tm1Tyj/\Nf1+
\Suz12Gt(Betageo)1Khe/\Suz12+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal melanocyte morphology J:217077
increased hepatocellular carcinoma incidence J:217077
increased histiocytic sarcoma incidence J:217077
increased intestinal adenoma incidence J:217077
increased lymphoma incidence J:217077
increased neurofibroma incidence J:217077
increased neurofibrosarcoma incidence J:217077
increased Schwannoma incidence J:217077
increased tumor incidence J:217077
premature death J:217077
\Nf1tm1Tyj/\Nf1+
\Suz12Gt(Betageo)1Khe/\Suz12+
\Trp53tm1Tyj/\Trp53+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		increased glioma incidence J:217077
increased hemangiosarcoma incidence J:217077
increased histiocytic sarcoma incidence J:217077
increased lymphoma incidence J:217077
increased neurofibrosarcoma incidence J:217077
increased tumor incidence J:217077
premature death J:217077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory