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Nkx6-1 Gene Detail
Summary
  • Symbol
    Nkx6-1
  • Name
    NK6 homeobox 1
  • Synonyms
    Nkx6.1, NKX6A
Location &
Maps
more
  • Sequence Map
    Chr5:101807050-101812577 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1206039
 protein coding gene Chr5:101806005-101812862 (-)
129S1/SvImJ ENSMUSG00200005096
 protein coding gene Chr5:95549256-95556088 (-)
A/J ENSMUSG00195032254
 protein coding gene Chr5:95115392-95122257 (-)
AKR/J ENSMUSG00220037581
 protein coding gene Chr5:94597589-94604419 (-)
BALB/cJ ENSMUSG00180030699
 protein coding gene Chr5:95271300-95278129 (-)
C3H/HeJ ENSMUSG00175029154
 protein coding gene Chr5:97376026-97382888 (-)
C57BL/6NJ ENSMUSG00215011627
 protein coding gene Chr5:95191543-95198404 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027461
 protein coding gene Chr5:94579720-94586458 (-)
CAST/EiJ ENSTCUG00005021263
 protein coding gene Chr5:94555375-94562237 (-)
CBA/J ENSMUSG00210030244
 protein coding gene Chr5:96126321-96133178 (-)
DBA/2J ENSMUSG00185035350
 protein coding gene Chr5:99044851-99051711 (-)
FVB/NJ ENSMUSG00205029912
 protein coding gene Chr5:95021338-95028204 (-)
JF1/MsJ ENSUMUG00000005914
 protein coding gene Chr5:101997463-102004318 (-)
LP/J ENSMUSG00230025292
 protein coding gene Chr5:103091397-103097093 (-)
NOD/ShiLtJ ENSMUSG00190024811
 protein coding gene Chr5:95021757-95028587 (-)
NZO/HlLtJ ENSMUSG00225012326
 protein coding gene Chr5:110860125-110866984 (-)
PWK/PhJ ENSLUMG00010013823
 protein coding gene Chr5:94109140-94115991 (-)
SPRET/EiJ ENSMSPG00010022049
 protein coding gene Chr5:97031982-97037775 (-)
WSB/EiJ ENSIUOG00005029746
 protein coding gene Chr5:97750381-97757215 (-)



Homology
more
  • Human Ortholog
    NKX6-1, NK6 homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKX6-1, NK6 homeobox 1
  • Synonyms
    NKX6.1, NKX6A
  • Links
    NCBI Gene ID: 4825
    UniProt: P78426

  • Chr Location
    4q21.23; chr4:84491985-84499292 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, abnormal neuron specification, decreased motor neuron number, and reduced pancreatic beta cell number and insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1185
  • Tissues
    219
  • cDNA Data
    10
  • Literature Summary
    431
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18096 NCBI Gene Model | MGI Sequence Detail 5528 C57BL/6J ±  kb
    transcript NM_144955 RefSeq | MGI Sequence Detail 1808 C57BL/6  
    polypeptide Q99MA9 UniProt | EBI | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 13
      Primer pair 10
      Other 11
      Antibodies 32

      Microarray probesets 2
    References
    more
    • Summaries
      All 495
      Developmental Gene Expression 431
      Gene Ontology 20
      Phenotypes 37
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:383447 Overton DL, et al., Translating the blueprint of cell fate: eIF5A-mediated translation regulates cellular identity in the pancreas. Mol Metab. 2026 Apr 2;107:102362
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory