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Nkx6-1 Gene Detail
Summary
  • Symbol
    Nkx6-1
  • Name
    NK6 homeobox 1
  • Synonyms
    Nkx6.1, NKX6A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1206039
    NCBI Gene: 18096
  • Gene Overview
    MyGene.info: NKX6-1
Location & Maps
more
  • Sequence Map
    Chr5:101658139-101664996 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6858 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NKX6-1, NK6 homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NKX6-1, NK6 homeobox 1
    Orthology source: HomoloGene
  • Synonyms
    NKX6.1, NKX6A
  • Links
    NCBI Gene ID: 4825
    neXtProt AC: NX_P78426

  • Chr Location
    4q21.33; chr4:84491987-84499141 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    3 involving Nkx6-1
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit neonatal lethality, abnormal neuron specification, decreased motor neuron number, and reduced pancreatic beta cell number and insulin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037547 VEGA Gene Model | MGI Sequence Detail 6858 C57BL/6J ±  kb
transcript OTTMUST00000096793 VEGA | MGI Sequence Detail 3138 Not Applicable  
polypeptide OTTMUSP00000054116 VEGA | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    88 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 18
    cDNA 10
    Primer pair 4
    Other 4

    Microarray probesets 2
References
more
  • Summaries
    All 302
    Developmental Gene Expression 275
    Gene Ontology 17
    Phenotypes 29
  • Earliest
    J:46928 Qiu M, et al., Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. Mech Dev. 1998 Mar;72(1-2):77-88
  • Latest
    J:229947 Luo SX, et al., Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly. Am J Pathol. 2016 Mar;186(3):478-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory