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Nkx6-1
Gene Detail
Symbol

Name
ID
Nkx6-1
NK6 homeobox 1
MGI:1206039
Synonyms
Nkx6.1, NKX6A
Feature Type
protein coding gene
Genetic Map
Chromosome 5
48.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:101659177-101664996 bp, - strand
From VEGA annotation of GRCm38

  5820 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Nkx6-1

Human
homologs
Human Homolog NKX6-1, NK6 homeobox 1
NCBI Gene ID 4825
neXtProt AC  NX_P78426
Human Synonyms  NKX6.1, NKX6A
Human Chr (Location)  4q21.33; chr4:84493148-84499154 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality, abnormal neuron specification, decreased motor neuron number, and reduced pancreatic beta cell number and insulin secretion.
 
Interactions
Nkx6-1 interacts with 176 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cell differentiation, cell proliferation, ...
Component extracellular vesicular exosome, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (244 records)
Data Summary: Results (250)    Tissues (135)    Images (101)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 54
RNA in situ 182
Northern blot 2
RT-PCR 12
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(10) Primer pair(4) Other(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037547 (Evidence)
Ensembl Gene ModelENSMUSG00000035187 (Evidence)
Entrez Gene18096 (Evidence)
UniGene193072
DFCITC1590209
DoTSDT.55231979
NIA Mouse Gene IndexU026463
Consensus CDS ProjectCCDS19471.1
International Mouse Knockout Project StatusNkx6-1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037547 VEGA Gene Model | MGI Sequence Detail 5820 C57BL/6J ±  kb
transcript OTTMUST00000096793 VEGA | MGI Sequence Detail 2100 Not Applicable 
polypeptide OTTMUSP00000054116 VEGA | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011250 homeobox protein Nkx-6.1
References
(Earliest) J:46928 Qiu M, et al., Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. Mech Dev. 1998 Mar;72(1-2):77-88
(Latest) J:211665 Chaya T, et al., ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. EMBO J. 2014 Jun 2;33(11):1227-42
All references(275)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory