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Tcf7l2
Gene Detail
Symbol

Name
ID
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
MGI:1202879
Synonyms
mTcf-4B, mTcf-4E, Tcf4, Tcf-4, TCF4B, TCF4E
Feature Type
protein coding gene
Genetic Map
Chromosome 19
51.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:55741820-55933654 bp, + strand
From VEGA annotation of GRCm38

  191835 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TCF7L2
Gene Tree: Tcf7l2

Human
homologs
TCF7L2, transcription factor 7-like 2 (T-cell specific, HMG-box)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6934
neXtProt AC: NX_Q9NQB0

Human Synonyms: TCF4, TCF-4

Human Chr (Location): 10q25.3; chr10:112950219-113167678 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TCF7L2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Endonuclease-mediated(3) Gene trapped(15) Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Animals homozygous for a targeted mutation exhibit intestinal epithelia abnormalities and die shortly after birth. Mice heterozygous for some mutations display abnormalities in glucose homeostasis.
 
Interactions
Tcf7l2 interacts with 412 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (113 annotations)
Process blood vessel development, bone mineralization, ...
Component beta-catenin-TCF7L2 complex, catenin-TCF7L2 complex, ...
Function armadillo repeat domain binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (96 records)
Data Summary: Results (586)    Tissues (244)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 533
Northern blot 14
RT-PCR 11
cDNA source data(78)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TCF7L2 ; Xenbase tcf7l2 ; ZFIN tcf7l2    NEW 
Molecular
reagents
All nucleic(87) cDNA(80) Primer pair(5) Other(2)
Microarray probesets(8)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020410 VEGA Gene Model | MGI Sequence Detail 191835 C57BL/6J ±  kb
transcript OTTMUST00000048437 VEGA | MGI Sequence Detail 3059 Not Applicable 
polypeptide OTTMUSP00000022201 VEGA | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(239) RefSeq(100) UniProt(15)
Polymorphisms
SNPs within 2kb(1134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027397 Catenin binding domain
InterPro IPR013558 CTNNB1 binding, N-teminal
InterPro IPR009071 High mobility group box domain
InterPro IPR028773 Transcription factor 7-like 2
InterPro IPR024940 Transcription factor TCF/LEF
Protein Ontology PR:000016186 transcription factor 7-like 2
References
(Earliest) J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
(Latest) J:221338 Hammond E, et al., The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci. 2015 Mar 25;35(12):5007-22
All references(164)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory