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Tcf7l2
Gene Detail
Symbol

Name
ID
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
MGI:1202879
Synonyms
mTcf-4B, mTcf-4E, Tcf4, Tcf-4, TCF4B, TCF4E
Feature Type
protein coding gene
Genetic Map
Chromosome 19
51.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:55741820-55933654 bp, + strand
From VEGA annotation of GRCm38

  191835 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tcf7l2

Human
homologs
Human Homolog TCF7L2, transcription factor 7-like 2 (T-cell specific, HMG-box)
NCBI Gene ID 6934
neXtProt AC  NX_Q9NQB0
Human Synonyms  TCF4, TCF-4
Human Chr (Location)  10q25.3; chr10:112950219-113167678 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TCF7L2
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Endonuclease-mediated(3) Gene trapped(15) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a targeted mutation exhibit intestinal epithelia abnormalities and die shortly after birth. Mice heterozygous for some mutations display abnormalities in glucose homeostasis.
 
Interactions
Tcf7l2 interacts with 412 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (111 annotations)
Process blood vessel development, bone mineralization, ...
Component beta-catenin-TCF7L2 complex, catenin-TCF7L2 complex, ...
Function armadillo repeat domain binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (91 records)
Data Summary: Results (574)    Tissues (233)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 16
RNA in situ 533
Northern blot 14
RT-PCR 11
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) cDNA(80) Primer pair(5) Other(2)
Microarray probesets(8)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020410 VEGA Gene Model | MGI Sequence Detail 191835 C57BL/6J ±  kb
transcript OTTMUST00000048437 VEGA | MGI Sequence Detail 3059 Not Applicable 
polypeptide OTTMUSP00000022201 VEGA | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(254) RefSeq(116) UniProt(15)
Polymorphisms
SNPs within 2kb(1134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027397 Catenin binding domain
InterPro IPR013558 CTNNB1 binding, N-teminal
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR024940 Transcription factor TCF/LEF
Protein Ontology PR:000016186 transcription factor 7-like 2
References
(Earliest) J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
(Latest) J:208262 Lien WH, et al., In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nat Cell Biol. 2014 Feb;16(2):179-90
All references(155)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory