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Tcf7l2 Gene Detail
Summary
  • Symbol
    Tcf7l2
  • Name
    transcription factor 7 like 2, T cell specific, HMG box
  • Synonyms
    mTcf-4B, mTcf-4E, Tcf4, Tcf-4, TCF4B, TCF4E
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202879
    NCBI Gene: 21416
Location & Maps
more
  • Sequence Map
    Chr19:55741820-55933654 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      191835 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TCF7L2, transcription factor 7-like 2 (T-cell specific, HMG-box)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TCF7L2, transcription factor 7-like 2 (T-cell specific, HMG-box)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TCF4, TCF-4
  • Links
    NCBI Gene ID: 6934
    neXtProt AC: NX_Q9NQB0

  • Chr Location
    10q25.3; chr10:112950219-113167678 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TCF7L2 associations

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 15 alleles in 8 genetic backgrounds
    15 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Endonuclease-mediated
    3
  • Gene trapped
    15
  • Targeted
    12
  • Transgenic
    4
  • Incidental Mutations
Animals homozygous for a targeted mutation exhibit intestinal epithelia abnormalities and die shortly after birth. Mice heterozygous for some mutations display abnormalities in glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020410 VEGA Gene Model | MGI Sequence Detail 191835 C57BL/6J ±  kb
transcript OTTMUST00000048437 VEGA | MGI Sequence Detail 3059 Not Applicable  
polypeptide OTTMUSP00000022201 VEGA | MGI Sequence Detail 482 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1134 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 88
    cDNA 80
    Primer pair 5
    Other 3

    Microarray probesets 8
References
more
  • Summaries
    All 161
    Developmental Gene Expression 97
    Gene Ontology 32
    Phenotypes 34
  • Earliest
    J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
  • Latest
    J:221338 Hammond E, et al., The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci. 2015 Mar 25;35(12):5007-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory