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Tcf7l2 Gene Detail
Summary
  • Symbol
    Tcf7l2
  • Name
    transcription factor 7 like 2, T cell specific, HMG box
  • Synonyms
    mTcf-4B, mTcf-4E, Tcf4, Tcf-4, TCF4B, TCF4E
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202879
    NCBI Gene: 21416
  • Gene Overview
    MyGene.info: TCF7L2
  • Alliance
  • Transcription Start Sites
    50 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:55741810-55933654 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 51.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202879
protein coding gene Chr19:55741785-55933661 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025260
protein coding gene Chr19:56040207-56246478 (+)
A/J MGP_AJ_G0025236
protein coding gene Chr19:53280953-53475235 (+)
AKR/J MGP_AKRJ_G0025205
protein coding gene Chr19:54958379-55156863 (+)
BALB/cJ MGP_BALBcJ_G0025231
protein coding gene Chr19:53365863-53561311 (+)
C3H/HeJ MGP_C3HHeJ_G0024991
protein coding gene Chr19:55190661-55395360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025674
protein coding gene Chr19:57409130-57608816 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023086
protein coding gene Chr19:52212978-52409236 (+)
CAST/EiJ MGP_CASTEiJ_G0024456
protein coding gene Chr19:55200149-55409491 (+)
CBA/J MGP_CBAJ_G0024971
protein coding gene Chr19:60229824-60446792 (+)
DBA/2J MGP_DBA2J_G0025103
protein coding gene Chr19:53079506-53273175 (+)
FVB/NJ MGP_FVBNJ_G0025064
protein coding gene Chr19:52785731-52980797 (+)
LP/J MGP_LPJ_G0025189
protein coding gene Chr19:55905400-56115428 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025097
protein coding gene Chr19:59595626-59800463 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025732
protein coding gene Chr19:55178863-55381993 (+)
PWK/PhJ MGP_PWKPhJ_G0024204
protein coding gene Chr19:53016535-53211980 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024007
protein coding gene Chr19:53841584-54045743 (+)
WSB/EiJ MGP_WSBEiJ_G0024526
protein coding gene Chr19:55300613-55503258 (+)



Homology
more
  • Human Ortholog
    TCF7L2, transcription factor 7 like 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TCF7L2, transcription factor 7 like 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TCF4, TCF-4
  • Links
    NCBI Gene ID: 6934
    neXtProt AC: NX_Q9NQB0
    UniProt: Q9NQB0

  • Chr Location
    10q25.2-q25.3; chr10:112950219-113167678 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TCF7L2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    86 phenotypes from 15 alleles in 10 genetic backgrounds
    15 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals homozygous for a targeted mutation exhibit intestinal epithelia abnormalities and die shortly after birth. Mice heterozygous for some mutations display abnormalities in glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024985 Ensembl Gene Model | MGI Sequence Detail 191845 C57BL/6J ±  kb
    transcript ENSMUST00000111662 Ensembl | MGI Sequence Detail 3715 Not Applicable  
    polypeptide ENSMUSP00000107291 Ensembl | MGI Sequence Detail 606 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      19 Sequences
    • InterPro Domains
      IPR027397 Catenin binding domain superfamily
      IPR013558 CTNNB1 binding, N-teminal
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR028773 Transcription factor 7-like
      IPR024940 Transcription factor TCF/LEF
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 80
      Primer pair 5
      Other 3

      Microarray probesets 8
    References
    more
    • Summaries
      All 206
      Developmental Gene Expression 122
      Gene Ontology 34
      Phenotypes 42
    • Earliest
      J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
    • Latest
      J:263230 Helmbacher F, Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis. PLoS Biol. 2018 May;16(5):e2004734

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory