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Tcf7l2
Gene Detail
 Symbol
Name
ID
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
MGI:1202879
Synonyms mTcf-4B, mTcf-4E, Tcf4, Tcf-4, TCF4B, TCF4E
Feature Type protein coding gene
Genetic Map
Chromosome 19
51.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:55741820-55933654 bp, + strand
From VEGA annotation of GRCm38

  191835 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tcf7l2

Human
homologs
Human Homolog TCF7L2, transcription factor 7-like 2 (T-cell specific, HMG-box)
NCBI Gene ID 6934
neXtProt AC  NX_Q9NQB0
Human Synonyms  TCF4, TCF-4
Human Chr (Location)  10q25.3; chr10:112950219-113167678 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TCF7L2
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Endonuclease-mediated(3) Gene trapped(15) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a targeted mutation exhibit intestinal epithelia abnormalities and die shortly after birth. Mice heterozygous for some mutations display abnormalities in glucose homeostasis.
 
Interactions
Tcf7l2 interacts with 412 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (106 annotations)
Process blood vessel development, bone mineralization, ...
Component beta-catenin-TCF7L2 complex, catenin-TCF7L2 complex, ...
Function armadillo repeat domain binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (90 records)
Data Summary: Results (581)    Tissues (235)    Images (60)
Theiler Stages: 2, 3, 4, 5, 9, 11, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 16
RNA in situ 533
Northern blot 14
RT-PCR 18
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) cDNA(80) Primer pair(5) Other(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000020410 (Evidence)
Ensembl Gene ModelENSMUSG00000024985 (Evidence)
Entrez Gene21416 (Evidence)
UniGene139815
DFCITC1576789, TC1589368, TC1589691, TC1590945, TC1593611, TC1623547, TC1638533, TC1768387, TC1769434, TC1773383
DoTSDT.101142313, DT.101357888, DT.101408432, DT.101408435, DT.110868652, DT.530294, DT.55185608, DT.87026948, DT.91412082, DT.94276508, DT.94276515, DT.97413784, DT.97413785
NIA Mouse Gene IndexU019591
Consensus CDS ProjectCCDS29911.1, CCDS50469.1, CCDS50470.1, CCDS50471.1, CCDS50472.1, CCDS50473.1, CCDS50474.1
International Mouse Knockout Project StatusTcf7l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020410 VEGA Gene Model | MGI Sequence Detail 191835 C57BL/6J ±  kb
transcript OTTMUST00000048437 VEGA | MGI Sequence Detail 3059 Not Applicable 
polypeptide OTTMUSP00000022201 VEGA | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(254) RefSeq(116) UniProt(15)
Polymorphisms SNPs within 2kb(1134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027397 Catenin binding domain
InterPro IPR013558 CTNNB1 binding, N-teminal
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR024940 Transcription factor TCF/LEF
Protein Ontology PR:000016186 transcription factor 7-like 2
References (Earliest) J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
(Latest) J:208262 Lien WH, et al., In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nat Cell Biol. 2014 Feb;16(2):179-90
All references(153)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory