Symbol
Name
ID

Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
MGI:1202879

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Elevated circulating hepatic transaminase concentration	Diabetes mellitus	Type II diabetes mellitus	Insulin resistance
Disease(s) Associated with TCF7L2	Elevated circulating hepatic transaminase concentration	Diabetes mellitus	Type II diabetes mellitus	Insulin resistance
pancreatic cancer
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased insulin secretion

decreased circulating glucose level

hypoglycemia

increased circulating glucose level

decreased circulating insulin level

increased circulating insulin level

abnormal glucose homeostasis

impaired glucose tolerance

improved glucose tolerance

abnormal response/metabolism to endogenous compounds

Availability

Mouse Genotype

Tcf7l2^em1Nobr/Tcf7l2^em1Nobr

Tcf7l2^em2Nobr/Tcf7l2^em2Nobr

Tcf7l2^em3Nobr/Tcf7l2^em3Nobr

Tcf7l2^em1Nobr/Tcf7l2⁺

Tcf7l2^em2Nobr/Tcf7l2⁺

Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2⁺

Tg(RP11-466I19/Tcf7l2)1Nobr/0

Tcf7l2^tm1Geno/Tcf7l2^tm1Geno
Tg(Pdx1-cre)89.1Dam/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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