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Tcf21
Gene Detail
Symbol

Name
ID
Tcf21
transcription factor 21
MGI:1202715
Synonyms
bHLHa23, capsulin, epc, epicardin, Pod1, Pod-1, podocyte-expressed 1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
10.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:22817279-22820128 bp, - strand
From Ensembl annotation of GRCm38

  2850 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: basic helix-loop-helix transcription factor, Twist/Epicardin/Musculin types
Gene Tree: Tcf21

Human
homologs
Human Homolog TCF21, transcription factor 21
NCBI Gene ID 6943
neXtProt AC  NX_O43680
Human Synonyms  bHLHa23, POD1
Human Chr (Location)  6q23.2; chr6:133889121-133895537 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit hypoplastic lungs and kidneys with abnormal vasculature of these organs and the hemopericardium, and die at birth due to respiratory failure. Homozygotes for some mutations are also asplenic. Some alleles cause sex reversal in XY mice.
 
Interactions
Tcf21 interacts with 112 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (55 records)
Data Summary: Results (492)    Tissues (275)    Images (107)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 363
In situ reporter (knock in) 28
Northern blot 54
RT-PCR 47
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(1) cDNA(33) Primer pair(3) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000045680 (Evidence)
Entrez Gene21412 (Evidence)
UniGene16497
DFCITC1581267
DoTSDT.110632382, DT.525439, DT.55139270
NIA Mouse Gene IndexU031605
Consensus CDS ProjectCCDS23732.1
International Mouse Knockout Project StatusTcf21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045680 Ensembl Gene Model | MGI Sequence Detail 2850 C57BL/6J ±  kb
transcript ENSMUST00000049930 Ensembl | MGI Sequence Detail 1223 Not Applicable 
polypeptide ENSMUSP00000053178 Ensembl | MGI Sequence Detail 179 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016180 transcription factor 21
References
(Earliest) J:47105 Quaggin SE, et al., Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. Mech Dev. 1998 Feb;71(1-2):37-48
(Latest) J:204972 Wood MA, et al., Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus. Development. 2013 Nov;140(22):4522-32
All references(90)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory