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Tcf21 Gene Detail
Summary
  • Symbol
    Tcf21
  • Name
    transcription factor 21
  • Synonyms
    bHLHa23, capsulin, epc, epicardin, Pod1, Pod-1, podocyte-expressed 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202715
    NCBI Gene: 21412
  • Gene Overview
    MyGene.info: TCF21
Location & Maps
more
  • Sequence Map
    Chr10:22817279-22820128 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2850 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TCF21, transcription factor 21
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TCF21, transcription factor 21
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHa23, POD1
  • Links
    NCBI Gene ID: 6943
    neXtProt AC: NX_O43680

  • Chr Location
    6q23.2; chr6:133889121-133895537 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 5 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Tcf21
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit hypoplastic lungs and kidneys with abnormal vasculature of these organs and the hemopericardium, and die at birth due to respiratory failure. Homozygotes for some mutations are also asplenic. Some alleles cause sex reversal in XY mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045680 Ensembl Gene Model | MGI Sequence Detail 2850 C57BL/6J ±  kb
transcript ENSMUST00000049930 Ensembl | MGI Sequence Detail 1223 Not Applicable  
polypeptide ENSMUSP00000053178 Ensembl | MGI Sequence Detail 179 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016180 transcription factor 21
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 43
    Genomic 1
    cDNA 35
    Primer pair 3
    Other 4

    Microarray probesets 3
References
more
  • Summaries
    All 91
    Developmental Gene Expression 58
    Gene Ontology 14
    Phenotypes 24
  • Earliest
    J:47105 Quaggin SE, et al., Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. Mech Dev. 1998 Feb;71(1-2):37-48
  • Latest
    J:224773 Nurnberg ST, et al., Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. PLoS Genet. 2015 May;11(5):e1005155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory