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Tcf21 Gene Detail
Summary
  • Symbol
    Tcf21
  • Name
    transcription factor 21
  • Synonyms
    bHLHa23, capsulin, epc, epicardin, Pod1, Pod-1, podocyte-expressed 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202715
    NCBI Gene: 21412
  • Gene Overview
    MyGene.info: TCF21
Location & Maps
more
  • Sequence Map
    Chr10:22817263-22820128 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2866 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 10.33 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TCF21, transcription factor 21
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TCF21, transcription factor 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHa23, POD1
  • Links
    NCBI Gene ID: 6943
    neXtProt AC: NX_O43680
    UniProt: O43680

  • Chr Location
    6q23.2; chr6:133889121-133895537 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 5 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit hypoplastic lungs and kidneys with abnormal vasculature of these organs and the hemopericardium, and die at birth due to respiratory failure. Homozygotes for some mutations are also asplenic. Some alleles cause sex reversal in XY mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21412 NCBI Gene Model | MGI Sequence Detail 2866 C57BL/6J ±  kb
transcript NM_011545 RefSeq | MGI Sequence Detail 1240 Not Specified  
polypeptide O35437 UniProt | EBI | MGI Sequence Detail 179 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 43
    Genomic 1
    cDNA 35
    Primer pair 3
    Other 4

    Microarray probesets 3
References
more
  • Summaries
    All 102
    Developmental Gene Expression 61
    Gene Ontology 14
    Phenotypes 26
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:241168 Kanisicak O, et al., Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nat Commun. 2016 Jul 22;7:12260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory