Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and E-box binding activity. Involved in several processes, including metanephros development; regulation of transcription by RNA polymerase II; and skeletal muscle organ development. Acts upstream of or within several processes, including lung development; nephron development; and sex determination. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart and pericardium; and respiratory system. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human TCF21 (transcription factor 21).