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Tert
Gene Detail
 Symbol
Name
ID
Tert
telomerase reverse transcriptase
MGI:1202709
Synonyms TR
Feature Type protein coding gene
Genetic Map
Chromosome 13
40.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:73627001-73649041 bp, + strand
From NCBI annotation of GRCm38

  22041 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31141  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tert

Human
homologs
Human Homolog TERT, telomerase reverse transcriptase
NCBI Gene ID 7015
neXtProt AC  NX_O14746
Human Synonyms  CMM9, DKCA2, DKCB4, EST2, hEST2, hTRT, PFBMFT1, TCS1, TP2, TRT
Human Chr (Location)  5p15.33; chr5:1253167-1295047 (-)  GRCh38
Disease Associations  (7) Diseases Associated with Human TERT
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
In spite of impaired telomerase function, homozygous mutant mice are overtly normal in early generations. Impaired fertility has been reported in later generations for homozygotes of at least one knockout allele.
 
Human Diseases Modeled Using Mouse Tert (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Tert interacts with 19 markers (Mir143, Mir214, Mir501, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process DNA biosynthetic process, DNA strand elongation, ...
Component chromosome, chromosome, telomeric region, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (144)    Tissues (73)    Images (9)
Theiler Stages: 2, 3, 4, 5, 15, 17, 21, 23, 28
Assay TypeResults
RNA in situ 72
RT-PCR 47
RNase protection 25
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(24) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021611 (Evidence)
Entrez Gene21752 (Evidence)
UniGene10109
DFCITC1586087, TC1602555, TC1764698
DoTSDT.102555452, DT.55210515, DT.87049267, DT.97388215
NIA Mouse Gene IndexU015001
EC2.7.7.49
Consensus CDS ProjectCCDS26633.1
International Mouse Knockout Project StatusTert
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21752 NCBI Gene Model | MGI Sequence Detail 22041 C57BL/6J ±  kb
transcript NM_009354 RefSeq | MGI Sequence Detail 3426 Not Specified 
polypeptide O70372 UniProt | EBI | MGI Sequence Detail 1122 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(14) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000477 Reverse transcriptase
InterPro IPR021891 Telomerase ribonucleoprotein complex - RNA-binding domain
InterPro IPR003545 Telomere reverse transcriptase
Protein Ontology PR:000016238 telomerase reverse transcriptase
Graphical View of Protein Domain Structure
References (Earliest) J:47020 Greenberg RA, et al., Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene. 1998 Apr 2;16(13):1723-30
(Latest) J:199921 Le Saux CJ, et al., A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One. 2013;8(3):e58423
All references(96)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory