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Tert Gene Detail
Summary
  • Symbol
    Tert
  • Name
    telomerase reverse transcriptase
  • Synonyms
    TR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202709
    NCBI Gene: 21752
Location & Maps
more
  • Sequence Map
    Chr13:73627001-73649041 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22041 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.12 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TERT, telomerase reverse transcriptase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TERT, telomerase reverse transcriptase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMM9, DKCA2, DKCB4, EST2, hEST2, hTRT, PFBMFT1, TCS1, TP2, TRT
  • Links
    NCBI Gene ID: 7015
    neXtProt AC: NX_O14746
    UniProt: O14746

  • Chr Location
    5p15.33; chr5:1253167-1295626 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with human TERT associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 9 alleles in 9 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In spite of impaired telomerase function, homozygous mutant mice are overtly normal in early generations. Impaired fertility has been reported in later generations for homozygotes of at least one knockout allele.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021611 Ensembl Gene Model | MGI Sequence Detail 22041 C57BL/6J ±  kb
transcript ENSMUST00000022104 Ensembl | MGI Sequence Detail 3426 Not Applicable  
polypeptide ENSMUSP00000022104 Ensembl | MGI Sequence Detail 1122 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    192 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 25
    Primer pair 6

    Microarray probesets 4
References
more
  • Summaries
    All 126
    Developmental Gene Expression 13
    Diseases 2
    Gene Ontology 14
    Phenotypes 62
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:237368 Khattar E, et al., Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression. J Clin Invest. 2016 Oct 03;126(10):4045-4060

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory